Tiny engineered therapeutic delivery system safely solves genetic problems in mice

Researchers report in Science Advances that the lipid-based nanoparticles they have engineered, carrying two sets of protein-making instructions, showed in animal studies that they have the potential to function as therapies for two genetic disorders.

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“Love hormone” oxytocin could be used to treat cognitive disorders like Alzheimer’s

Alzheimer’s disease is a progressive disorder in which the nerve cells (neurons) in a person’s brain and the connections among them degenerate slowly, causing severe memory loss, intellectual deficiencies, and deterioration in motor skills and communication.

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US hydroxychloroquine, chloroquine, azithromycin outpatient prescriptions October 2019-March 2020

What The Study Did: How the prescription of hydroxychloroquine and chloroquine to outpatients has changed in the United States during the COVID-19 pandemic is examined in this study.

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One-Time Treatment Generates New Neurons, Eliminates Parkinson’s Disease in Mice

UC San Diego researchers have discovered that a single treatment to inhibit a gene called PTB in mice converts native astrocytes, brain support cells, into neurons that produce the neurotransmitter dopamine. As a result, the mice’s Parkinson’s disease symptoms disappear.

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Immune Cells Infiltrating Tumors May Play Bigger Cancer Role Than Previously Thought

UC San Diego researchers uncovered in mice how IRE1α, a molecule involved in cells’ response to stress, determines whether macrophages promote inflammation in the tumor microenvironment. Inflammation is known to promote tumor growth, making IRE1α an attractive target for drug development.

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Clear signs of brain injury with severe COVID-19

Certain patients who receive hospital care for coronavirus infection (COVID-19) exhibit clinical and neurochemical signs of brain injury, a University of Gothenburg study shows. In even moderate COVID-19 cases, finding and measuring a blood-based biomarker for brain damage proved to be possible.

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