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UrduTaken together these Oncotarget findings show that the CTD and OD domains of mtp53 R273H play critical roles in mutant p53 GOF that pertain to processes associated with DNA replication.
Tag: POLICY/ETHICS
Oncotarget: TERT and its binding protein: overexpression of GABPA/B in gliomas
This Oncotarget study confirms the upregulation of TERT in primary glioblastomas while all GABP proteins rise with the malignancy of the gliomas
Oncotarget: Fgr and Numb in retinoic differentiation and G0 arrest of non-APL AML cells
In sum the Oncotarget data support a paradigm where signaling molecules bound to a Numb scaffold in a signalsome are activated by RA-induced Fgr expression
Shedding light on the dark side of firm lobbying
News from the Journal of Marketing
Longer stays in refugee camps increase cases of acute mental illness
New research shows serious effects of time spent in Moria refugee camp on mental health deterioration.
Expenses for university R&D&I increase moderately in Spain
According to the IUNE Observatory’s 2021 Report
What makes a market transaction morally repugnant?
Study uncovers the psychological drivers of our feelings of repugnance
Oncotarget: Subtypes of thymic epithelial tumors independent of WHO type
These Oncotarget results may reflect the unselected patient population enrolled in these studies, including no selection for WHO histologic subtype or molecular aberrations.
The Big Ten Academic Alliance joins Direct to Open from the MIT Press
BTAA libraries commit to making knowledge more open and equitable and will enjoy benefits exclusive to participating libraries
A global comparison of life-cycle GHG emissions from passenger cars
A far-reaching new study of the life-cycle greenhouse gas (GHG) emissions from passenger cars, including SUVs, draws sharp and meticulous distinctions between the climate impacts of battery and fuel cell electric vehicles on one hand and combustion vehicles on the…
New analysis reveals global distribution of toxic pollution and climate change
And provides top-ten list of countries at highest risk — and likely most equipped to immediately begin pollution risk reduction
Over 1/3 of US Congress members hold healthcare-related financial assets
Over 1/3 of US Congress members hold healthcare-related financial assets, with a median value of $43,000, according to analysis of healthcare conflicts of interest using 11 years of data. ### Article Title: Historical trends in health care-related financial holdings among…
New in the Hastings Center Report, July-August 2021
Should ethicists be activists? Four calls to action, and more
Neural model seeks ‘inappropriateness’ to reduce chatbot awkwardness
Researchers from Skoltech and their colleagues from Mobile TeleSystems have introduced the notion of inappropriate text messages and released a neural model capable of detecting them, along with a large collection of such messages for further research. Among the potential…
Inadequate protection for women and girls seeking refuge in Germany
“Shadow report” with input from the University of Göttingen criticises the Federal Government’s implementation of the Istanbul Convention
Angry politicians make angry voters, new study finds
Politicians may have good reason to turn to angry rhetoric, according to research led by political scientists from Colorado–the strategy seems to work, at least in the short term. In a new study, Carey Stapleton at the University of Colorado…
Oncotarget: Biomechanics in response to drug in hypoxia by atomic force spectroscopy
These Oncotarget results show that a degree of chemotherapeutic drug effects on biomechanical and biophysical properties of cancer cells is distinguishable in normoxia and hypoxia`
Oncotarget: Cutaneous apocrine sweat gland carcinoma
Together these Oncotarget results describe the first ever CAC case with a BRCAness genetic background
Oncotarget: Caspase-11 and AIM2 inflammasome involved in COPD and lung adenocarcinoma
The Oncotarget authors found that AIM2 inflammasome is at the crossroad between COPD and lung cancer in that its higher presence is correlated to lower survival rate of smoking COPD adenocarcinoma patients.
Discrimination and safety concerns barriers to accessing healthy food for food-insecure young adults
New study in the Journal of the Academy of Nutrition and Dietetics indicates interventions of specific relevance to COVID-19, including expanded food assistance services, are needed to improve the accessibility of healthy food for young adults
New Zealand drug agency provides model to insulate NICE from impacts of trade deals
UK policymakers preparing trade deals post-Brexit can learn important lessons from New Zealand’s ‘unique drug agency’ the Pharmaceutical Management Agency (PHARMAC), if prices for therapies and access to key drugs are to be protected, say researchers behind a new study…
Oncotarget: RAS reversion in colorectal cancer patients treated with bevacizumab
This Oncotarget finding might have potential therapeutic implications, as anti-EGFR could be reconsidered in primarily RAS mutant patients reverted to a wild-type status after bevacizumab exposure.
Study: Incarcerated people placed in solitary confinement differ significantly from others in prison population
Concern has grown about prison systems’ use of extended solitary confinement as a way to manage violent and disruptive incarcerated people. A new study identified groups that are more likely to be placed in extended solitary management (ESM). The study…
A watershed moment for post-Covid UK social policy
Authors of a new book call for the focus to be firmly on medical care, food, housing, ‘other necessary social services’ and access to digital technology.
The GovLab launches free online course on “Open Justice”
BROOKLYN, New York, Thursday, July 15, 2021 – Today, The GovLab in partnership with the Electoral Tribunal of the Federal Judiciary of Mexico (TEPJF) , launched a first of its kind, online course on Open Justice through the edX MOOC…
Oncotarget: CEA as a blood-based biomarker in anal cancer
CEA is not associated with survival outcomes in SCCA, and is not a clinically relevant biomarker in this disease
Cocoa bean DNA testing offers path to end slavery and child labour in chocolate industry
Research shows low-cost DNA biomarker technique can trace cocoa from a specific farm to the chocolate bar in your hand
How corporate managers try to fix workplace injustices by giving employees secret perks
A new study co-authored by the UBC Sauder School of Business has found that when senior managers mistreat workers, middle managers often attempt to quietly smooth things over. Robin Hood was known for stealing from the rich and giving to…
Vaccine hesitancy in young adults may hamper herd immunity
Questions about safety, side effects preclude youth from getting COVID shot, UCSF study shows
Off-cycle elections result in less representative local governments
Americans tend to be far more consumed with national politics than with local politics. As places like Utah, Arizona, Michigan and Maryland gear up to hold local elections this summer and fall, history predicts that they will see an average…
Experts advocate for ’employment first, employment for all’ for workers with disabilities
Inclusionary values are emphasized in this special issue of the Journal of Vocational Rehabilitation, which presents contributions from the 2020 Conference of the Association of People Supporting Employment First (APSE)
UCLA research finds the US lags 79 other nations in preventing child immigration detention
The COVID-19 pandemic has amplified calls to end the detention of migrant children, as cases surge among children held in crowded conditions; yet immigration detention’s threats to children’s fundamental rights did not begin with the current public health crisis. Unlike…
ICE violated internal medical standards, potentially contributing to deaths
A USC analysis of deaths among individuals in U.S. Immigration and Customs Enforcement custody found that ICE violated its own internal medical care standards in 78% of cases, potentially contributing to deaths in relatively young and healthy men.
Leading cardiovascular organizations issue joint opinion on improving clinician well-being worldwide
Paper addresses drivers and impacts of burnout, suggests strategies for the betterment of cardiovascular workforce
Global study reveals effectiveness of protected area
Certain countries perform significantly better than their neighbors in the effectiveness of their protected areas, finds new study.
Stopping illegal trade of Aussie lizards
Australian reptiles face serious conservation threats from illegal poaching fueled by international demand and the exotic pet trade. In a new study in Animal Conservation , researchers from the University of Adelaide and the Monitor Conservation Research Society (Monitor) investigated…
Global study reveals effectiveness of protected areas
Certain countries perform significantly better than their neighbors in the effectiveness of their protected areas, finds new study.
US-wide, non-white neighborhoods are hotter than white ones
Wealthier, whiter urban and small-town residents benefit more from cooling infrastructure and trees
Farm robots are the future; let’s start preparing now, researcher argues
No longer science fiction, farm robots are already here–and they have created two possible extremes for the future of agriculture and its impacts on the environment, argues agricultural economist Thomas Daum in a Science & Society article published July 13…
Oncotarget: Inhibitory effects of Tomivosertib in acute myeloid leukemia
These Oncotarget findings demonstrate that Tomivosertib exhibits potent anti-leukemic properties on AML cells and support the development of clinical translational efforts involving the use of this drug
Oncotarget: Modulating Tau Post-translational modifications and cytoskeletal network
EGCG, a green tea polyphenol, as a modulator of in vitro methylglyoxal-induced Tau glycation and its impact on reducing advanced glycation end products in neuroblastoma cells.
Oncotarget: LAPAS1 is required for S phase progression and cell proliferation
They identify LAPAS1 as a novel E2F-regulated lncRNA that has a potential role in human cancer and regulates cell-cycle progression and cell proliferation
Near the toys and the candy bars–
Comprehensive Hebrew U. audit uncovers tobacco companies’ sneaky tactics to circumvent regulators and target kids
HighT-Tech’s innovative approach to catalyst development wins The Spinoff Prize 2021
London | New York | Darmstadt, 12 July 2021 The Spinoff Prize 2021, a Nature Research Award supported by Merck KGaA, Darmstadt, Germany has been awarded to HighT-Tech, a spinoff* of The University of Maryland, College Park in the United…
Sea-level rise solutions
Stanford researchers map how sea-level rise adaptation strategies impact economies and floodwaters
Oncotarget: Urine RNA reveal tumor markers for human bladder cancer
This Oncotarget work strongly suggests exploiting urine RNAs as diagnostic markers of bladder cancer and it suggests specific novel markers.
The ethics of split liver transplantation: Analyzing case studies to make the right decision
Split liver transplantation (SLT) provides an opportunity to divide a donor liver and offer transplants to two small patients, one or both of whom could be a child. SLT, which is underused in the United States, could be used more…
Researchers propose a scheme that treats carbon emissions like financial debt
Paying off our carbon debt
Wage inequality negatively impacts customer satisfaction and does not improve long-term firm performance
News from the Journal of Marketing
Oncotarget: miRNA signatures from epidermal growth factor inhibitor patients
This Oncotarget study suggests that miR-21, miR-31 and miR-520e expression might be a treatment dependent marker for EGFRI induced skin rash.