The World Health Organization says monkeypox is a global health emergency. Scientists use ultrabright X-ray beams and diffraction imagery to understand how poxviruses behave. This can accelerate development of critical vaccines and treatments for monkeypox and other poxviruses.
Tiny antibodies in sharks have dexterity and flexibility that human antibodies do not. They can bind tightly to the spike proteins of coronaviruses and neutralize the virus. This could help researchers develop new vaccines and therapies for COVID-19.
Argonne, industry and academia collaborate to bring innovative AI and simulation tools to the COVID-19 battlefront.
Scientists using the Advanced Photon Source have discovered that a drug used to fight tumors in animals might be effective against many types of coronaviruses, including SARS-CoV-2.
Two teams of researchers using the Advanced Photon Source identified existing drugs — one used to treat cancer, the other an anti-seizure medication — that may work as treatments for COVID-19.
For the first time, a team of researchers has captured X-ray images of a critical enzyme of the COVID-19 virus performing its function. This discovery could improve design of new treatments against the disease.
In advance of Argonne’s Aurora exascale supercomputer, Duke University assistant professor Amanda Randles is leading a new study to analyze cancer metastasis using HARVEY, a code that simulates blood vessels within the human body.
As the fight against COVID-19 continues, scientists have turned to an unlikely source for a potentially effective treatment: tiny antibodies naturally generated by llamas.
Argonne scientists are using wastewater-based epidemiology to provide a safe and cost-effective way to measure community spread of COVID-19 and the SARS-CoV-2 virus.
The research team used the Advanced Photon Source to confirm an effective antibody that prevents the dengue virus from infecting cells in mice, and may lead to treatments for this and similar diseases.
Argonne scientists and research facilities have made a difference in the fight against COVID-19 in the year since the first gene sequence for the virus was published.
More than a decade of virus research at the APS laid the groundwork for more effective COVID-19 vaccines and helped speed their rapid development.
The APS has been a powerful tool in the battle against the novel coronavirus, contributing more information about the structure of the virus to the International Protein Databank than any other light source in the United States.
Using a combination of AI and supercomputing resources, Argonne researchers are examining the dynamics of the SARS-CoV-2 spike protein to determine how it fuses with the human host cell, advancing the search for drug treatments.
Argonne computational resources supported the largest comprehensive analysis of COVID-19 genome sequences in the U.S. and helped corroborate growing evidence of a protein mutation.
Irvine, Calif., April 29, 2020 — Researchers at the University of California, Irvine have developed a new mathematical machine-intelligence-based technique that spatially delineates highly complicated cell-to-cell and gene-gene interactions. The powerful method could help with the diagnosis and treatment of diseases ranging from cancer to COVID-19 through quantifing crosstalks between “good” cells and “bad” cells.
A research team led by Professor Dean Ho from the National University of Singapore has developed a ground-breaking artificial intelligence platform known as ‘IDentif.AI’ which can identify optimal drug combination therapies at unprecedented speeds.
Four types of human coronaviruses that cause common respiratory infections are sharply seasonal and appear to transmit similarly to influenza in the same population, according to a new study by University of Michigan School of Public Health researchers.
Argonne scientists are working around the clock to analyze the virus to find new treatments and cures, predict how it will propagate through the population, and make sure that our supply chains remain intact.
Irvine, Calif., March 23, 2020 – Researchers at the University of California, Irvine have shown that they can give cells a short-term boost of energy through mitochondrial transplantation. The team’s study, published today in the Journal of the American Heart Association, suggests that mitochondrial transplantation could one day be employed to cure various cardiovascular, metabolic and neurodegenerative disorders – and even offer a new approach to the treatment of cancer.
A potential drug target has been identified in a newly mapped protein of SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19). The structure was solved by a team including the University of Chicago (U of C), the U.S. Department of Energy’s (DOE) Argonne National Laboratory, Northwestern University Feinberg School of Medicine and the University of California, Riverside School of Medicine (UCR).
“Under-representation of Asian populations in genetic studies has meant that medical relevance for more than half of the human population is reduced,” one researcher said.
Scientists using specialized beamlines at Argonne’s Structural Biology Center (SBC), a facility for macromolecular crystallography at the Advanced Photon Source, derived insights that led to the discovery of a promising new drug for Ebola.