news, journals and articles from all over the world.
Gastrointestinal cancers were once diagnosed primarily by location. A tumor in the liver was liver cancer, while one in the pancreas was pancreatic. The few chemotherapy treatments available affected the entire patient—sometimes causing difficult side effects.
Scientists at St. Jude Research Hospital unravel the mechanisms behind a key culprit in chemotherapy resistance.
The research provides scientists with much-needed information to identify biological causes for congenital heart disease, or CHD.
Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint deterioration. The clinical outcomes of patients with active RA can be improved using anti-rheumatic medications, such as methotrexate (MTX).
A new CALM mutation causes lethal arrhythmia in humans. Using cardiomyocytes — or heart muscle cells — from human iPS cell and recombinant calmodulin proteins, the group studied catecholaminergic polymorphic ventricular tachycardia — or CPVT, a rare and life-threatening genetic condition. The team was able to reproduce severe arrhythmia in patient-derived iPS cell models of exercise-induced CPVT with calmodulin mutations.
microRNAs are thought to suppress protein expression in dividing cells, such as tumor cells. But new research in ACS Central Science shows that some of these molecules can elevate the expression of a particular gene in dividing human cells and in cancer cells, challenging conventional wisdom.
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