Mechanisms involved in the rapid, severe progression of fibrosis in the lung tissues of COVID-19 patients, a potentially fatal complication of the virus that damages and scars the lungs, have been uncovered by researchers led by UTHealth Houston.
UC Davis Health infectious diseases expert George Thompson warns of the rising threat and apparent spread of disease-causing fungi outside their traditional hot spots. Fungal lung infections are commonly misdiagnosed, leading to delays in treatment and increase in antimicrobial resistance in the community.
B. Smyth, 28, died on Nov. 17, 2022, after a long battle with pulmonary fibrosis, according to an Instagram post featuring his brother Denzil. Pulmonary fibrosis (PF) is a progressive, debilitating disease that causes scarring in the lungs and does not presently have a cure.
Lungs are essential to many vertebrates including humans. However, four living amphibian clades have independently eliminated pulmonary respiration and lack lungs, breathing primarily through their wet skin. Little is known of the developmental basis of lung loss in these clades.
Blood clots are thought to occur in as many as a third of patients hospitalized with COVID-19. In many cases these clots can be deadly, such as pulmonary embolisms—blood clots that travel to the lungs. In fact, in nearly one third of patients with COVID-19, these clots led to death.
Findings provide the foundation for future therapeutic strategies by promoting repair of the pulmonary vascular system.
McMaster University scientists who compared respiratory vaccine-delivery systems have confirmed that inhaled aerosol vaccines provide far better protection and stronger immunity than nasal sprays.
One of the largest studies to investigate whether Preserved Ratio Impaired Spirometry (PRISm), an understudied low lung function state, is an early predictor of co-morbidities has found it is strongly associated with an increased risk of death. The analysis, led by University of Bristol researchers and published in The Lancet Respiratory Medicine, evaluated results of lung spirometry tests in over 350,000 UK adults and followed them up over 12 years.
A new study adds to the evidence that chemotherapy enhances cancer’s spread beyond the primary tumor, showing how one chemo drug allows breast cancer cells to squeeze through and attach to blood vessel linings in the lungs.
Article title: Rapid postmortem ventilation improves donor lung viability by extending the tolerable warm ischemic time after cardiac death in mice Authors: Junyi Yu, Che Xu, Janet S. Lee, Jonathan K. Alder, Zongmei Wen, Guifang Wang, Agustin Alejandro Gil Silva,…
The nationwide pulmonary fibrosis (PF) community will take a collective step forward to advance research, advocacy, and awareness in the Pulmonary Fibrosis Foundation’s (PFF) National Walk Day on Saturday, Sept. 25, during Pulmonary Fibrosis Awareness Month.
September is Pulmonary Fibrosis Awareness Month, presented by the Pulmonary Fibrosis Foundation (PFF) as a way to drive awareness of pulmonary fibrosis (PF), a debilitating, incurable lung disease. Learn more about the numerous endeavors intended to rejuvenate the fight against PF throughout September.
Researchers at Weill Cornell Medicine and NewYork-Presbyterian in New York have discovered that injecting mice with pulmonary endothelial cells—the cells that line the walls of blood vessels in the lung—can reverse the symptoms of emphysema. The study, which will be published July 21 in the Journal of Experimental Medicine (JEM), may lead to new treatments for chronic obstructive pulmonary disease (COPD), an inflammatory lung disease associated with smoking that is thought to be the third leading cause of death worldwide.
A team of researchers from UCLA, Cedars-Sinai and the Cystic Fibrosis Foundation has developed a first-of-its-kind molecular catalog of cells in healthy lungs and the lungs of people with cystic fibrosis.
University of Miami Miller School of Medicine researchers led a unique and groundbreaking randomized controlled trial showing umbilical cord derived mesenchymal stem cell infusions safely reduce risk of death and quicken time to recovery for the severest COVID-19 patients, according to results published in STEM CELLS Translational Medicine in January 2021.
Osteopontin is discovered as the culprit behind these patients’ main cause of death. However, a repurposed immunosuppressive drug may combat the pro-inflammatory protein.
Researchers have developed a method using ultrasound imaging to score a patient’s lung health, which may help predict if a patient with COVID-19 will worsen. Using 14 points in the lungs, they looked for abnormalities and assigned each spot a score out of 3 based on its severity. Adding up all the points, the researchers found the total lung ultrasound score was higher for those who had a worsening outcome of COVID-19. Umberto Sabatini’s presentation will be a part of the 179th ASA Meeting of the Acoustical Society of America.
A new study published in the Environmental Health Perspectives connects insulin resistance and repetitive ozone exposure to the development of interstitial lung disease.
A team of American and Canadian researchers report that while they may feel uncomfortable, there is little empirical evidence that wearing a facemask significantly diminishes lung function, even when worn during heavy exercise.
The Pulmonary Fibrosis Foundation today announced the “Pinpoint PF” education and awareness campaign aimed at individuals with symptoms and at a higher risk for pulmonary fibrosis (PF).
October is Healthy Lung Month, an apt time to educate the public about the importance of protecting our lungs against mold, airborne pollutants and smoking – which put hundreds of thousands of Americans at higher risk for pulmonary fibrosis (PF).
Researchers have developed a technique that uses ultrasound to provide non-invasive assessments of pulmonary fibrosis and pulmonary edema. The technique has been shown to both quantify lung scarring and detect lung fluid in rats. A study on pulmonary edema in humans is under way.
Engineers have invented a way to spray extremely thin wires made of a plant-based material that could be used in N95 mask filters, devices that harvest energy for electricity, and potentially the creation of human organs. The method involves spraying methylcellulose, a renewable plastic material derived from plant cellulose, on 3D-printed and other objects ranging from electronics to plants, according to a Rutgers-led study in the journal Materials Horizons.
An international team led by current and former McMaster University researchers has developed an artificial lung to support pre-term and other newborn babies in respiratory distress.
September’s Pulmonary Fibrosis Awareness Month shares crucial realities and insights about the rare disease, its symptoms and helpful resources provided by the Pulmonary Fibrosis Foundation to educate the public about this devastating disease which impacts over 200,000 Americans.
A multidisciplinary team from Columbia Engineering and Vanderbilt University has now demonstrated that severely injured donor lungs that have been declined for transplant can be recovered outside the body by a system that uses cross-circulation of whole blood between the donor lung and an animal host. For the first time, a severely injured human lung that failed to recover using the standard clinical EVLP was successfully recovered during 24 hours on the team’s cross-circulation platform.
A major transformation in vertebrate evolution took place when breathing shifted from being driven by head and throat muscles—like in fish and frogs—to the torso—like in reptiles and mammals. But what caused the shift? A new study posits that the intermediate step was locomotion—the mechanics follow the same pattern as inhalation and exhalation.
Joe G. N. “Skip” Garcia, MD, an academic pulmonary physician-scientist describes a complication in COVID-19.
Many reports have included pulmonary fibrosis as a potential consequence of COVID-19. Data shows some COVID-19 patients develop scarring on the lungs – but not necessarily chronic pulmonary fibrosis or interstitial lung disease, which are characterized by progressive scarring.
Researchers report evidence that the compounds in e-cigarette liquid could potentially cause the body’s tissue repair process to go haywire and lead to scarring inside the lungs.
While both sexes have the capacity for phenomenal athletic achievements, women on average must work harder to breathe during strenuous exercise compared to men, according to new research.
An American Thoracic Society-led international task force has released a guidance document to help clinicians manage COVID-19 patients in the face of a worldwide pandemic and minimal empirical evidence to guide treatment. The new guidance – “COVID-19: Interim Guidance on Management Pending Empirical Evidence”– is published as an open access document on the American Thoracic Society’s website.
Montefiore Health System and Albert Einstein College of Medicine has joined a clinical trial to evaluate the experimental drug remdesivir to treat people who are hospitalized with severe COVID-19 infection.
Vaccine expert working on developing covid-19 vaccine, sees major differences between Covid-19 and SARS
Leading up to Earth Day on April 22, Cedars-Sinai is posting a weekly story and video that investigates the various ways climate change is impacting our bodies. This week’s topic: The Lungs and Climate Change.
Mammals inhale oxygen-rich air and they exhale depleted air, exhibiting a so-called tidal flow pattern. In contrast, bird breath travels through part of the respiratory system, but in a one-way loop throughout most of the lung. Biologists have discovered that Savannah monitor lizards have lung structures that are hybrid system of bird and mammal lungs.
In response to a new study which found that lung damage from vaping resembles chemical burns, Geraldine R. Britton, director of the Binghamton University Interdisciplinary Tobacco Use Research Program, offers the following. “Many have believed that the underlying problem with vaping…