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UrduResearchers at UT Southwestern Medical Center developed nanoparticles that successfully edited the disease-causing gene in the lungs of a mouse model of cystic fibrosis (CF), swapping a mutated form with a healthy one that persisted in stem cells. Their findings, reported in Science, could offer hope for people with CF and other debilitating genetic lung diseases.
Tag: Lungs
نصائح خبراء مايو كلينك لحماية رئتيك وسط أدخنة حرائق الغابات
عند اندلاع حرائق الغابات يواجه سكان المنطقة وفي بعض الأحيان المناطق خارجها، صعوبة متزايدة في التنفس. حيث تحمل الرياح الدخان لمسافة العديد من مئات الأميال من موقع الحريق الفعلي وفقًا لتصريح الطبيب كلايتون كاول، دكتور في الطب والذي يعمل كطبيب أمراض الرئة وعلم السموم الإكلينيكي في مايو كلينك.
Liquid crystal nanoparticles supercharge antibiotics for cystic fibrosis
Cystic fibrosis is the most common, life-limiting genetic condition in Australia. It affects the lungs, digestive system, and reproductive system, producing excess mucus, infections, and blockages.
Study provides new insights into deadly acute respiratory distress syndrome (ARDS)
Researchers at the University of Minnesota Twin Cities may have discovered a mechanical explanation for instability observed in the lungs in cases of acute respiratory distress syndrome (ARDS), particularly in the aftermath of respiratory illnesses such as COVID-19 or pneumonia.
How the Body Copes with Airway Closure
Study in mice reveals novel gasping reflex triggered by cells in the lungs when the airway is restricted
Scientists discover hidden army of lung flu fighters
Scientists have long thought of the fluid-filled sac around our lungs merely as a cushion from external damage.
Systemic Sclerosis-associated Interstitial Lung Disease Focus of Latest Clinical Practice Guideline
In patients with systemic sclerosis (SSc), a rare connective tissue disease, interstitial lung disease contributes to 35 percent of deaths. Published recently in the American Journal of Respiratory and Critical Care Medicine, the latest American Thoracic Society Clinical Practice Guideline makes a number of recommendations. One recommendation expands antifibrotic treatment to all patients with systemic sclerosis associated with ILD (SSc-ILD), not just those with progressive disease.
Watch the explainer video.
Suspected bronchiectasis associated with higher risk of mortality in smokers
Bronchiectasis, a condition defined by widened lung airways, cough and sputum production, and frequent infections, often presents along with chronic obstructive pulmonary disease (COPD).
Computer model predicts who needs lung cancer screening
A machine learning model equipped with only data on people’s age, smoking duration and the number of cigarettes smoked per day can predict lung cancer risk and identify who needs lung cancer screening, according to a new study publishing October 3rd in the open access journal PLOS Medicine by Thomas Callender of University College London, UK, and colleagues.
Researchers discover disease-causing stem cells in lungs of cystic fibrosis patients
Two nationally recognized experts in cloning and stem cell science from the University of Houston, Wa Xian and Frank McKeon, are reporting that five lung stem cell variants dominate the lungs of patients with advanced cystic fibrosis (CF), and that these variants drive key aspects of CF pathology including inflammation, fibrosis and mucin secretion.
Pulmonary embolism deaths, disparities high despite advancements in care
Despite advancements in care, a Michigan Medicine study finds that the death rate for pulmonary embolism remains high and unchanged in recent years – more often killing men, Black patients and those from rural areas.
Omega-3 fatty acids promising for maintaining lung health
Omega-3 fatty acids, which are abundant in fish and fish oil supplements, appear promising for maintaining lung health, according to a Cornell-led study supported by the National Institutes of Health (NIH).
One pill doesn’t fit all: cholesterol study reveals effects on lung function and brain size
The first study in the world to compare cholesterol-lowering medications on a range of diseases has good and bad news for more than 200 million people.
Mapping DNA damage from exposure to a compound in cigarette, industrial smoke
A compound found in cigarette and industrial smoke, benzo(a)pyrene (BaP), is known to damage DNA. Now, researchers reporting in ACS Central Science have mapped these effects for the first time in human lung cells after BaP exposure, which could help predict exposures that lead to cancers.
Chronic Alcohol Use May Increase Risk for SARS-CoV2 Infection, Study Suggests
A newly published animal study found that chronic alcohol consumption may create conditions in the body that can facilitate infection by SARS-CoV2, the virus that causes COVID-19 disease. The study, published in Alcohol: Clinical and Experimental Research, found that chronic alcohol use increased the levels of an enzyme that helps the virus enter the cells and, therefore, may increase the risk for COVID-19.
Scientists discover receptor that blocks COVID-19 infection
University of Sydney scientists have discovered a protein in the lung that blocks SARS-CoV-2 infection and forms a natural protective barrier in the human body.
Screening teens for vaping history key to diagnosing lung disease during pandemic
The severity of a lung disease associated with e-cigarettes in teens decreased during the COVID-19 pandemic, but hospitalizations from the disease continued to mount, according to a study of more than three dozen patients by UT Southwestern researchers published in Pediatric Pulmonology.
Investigators capture a “molecular snapshot” to illuminate the origins of pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) is a rare and incurable disease of the lung arteries that causes early death.
Research reveals how a potentially fatal COVID-19 complication damages lung tissue
Mechanisms involved in the rapid, severe progression of fibrosis in the lung tissues of COVID-19 patients, a potentially fatal complication of the virus that damages and scars the lungs, have been uncovered by researchers led by UTHealth Houston.
Physicians urged to consider fungal infections as possible cause for lung inflammation
UC Davis Health infectious diseases expert George Thompson warns of the rising threat and apparent spread of disease-causing fungi outside their traditional hot spots. Fungal lung infections are commonly misdiagnosed, leading to delays in treatment and increase in antimicrobial resistance in the community.
Pulmonary Fibrosis Claims Life of R&B Singer B. Smyth
B. Smyth, 28, died on Nov. 17, 2022, after a long battle with pulmonary fibrosis, according to an Instagram post featuring his brother Denzil. Pulmonary fibrosis (PF) is a progressive, debilitating disease that causes scarring in the lungs and does not presently have a cure.
Lungless salamanders develop lungs as embryos despite lung loss in adults for millions of years
Lungs are essential to many vertebrates including humans. However, four living amphibian clades have independently eliminated pulmonary respiration and lack lungs, breathing primarily through their wet skin. Little is known of the developmental basis of lung loss in these clades.
SuPAR identifies patients at high risk of blood clot formation
Blood clots are thought to occur in as many as a third of patients hospitalized with COVID-19. In many cases these clots can be deadly, such as pulmonary embolisms—blood clots that travel to the lungs. In fact, in nearly one third of patients with COVID-19, these clots led to death.
Researchers identify protein connected to aging and idiopathic pulmonary fibrosis
Findings provide the foundation for future therapeutic strategies by promoting repair of the pulmonary vascular system.
Going all the way: Scientists prove that inhaled vaccines offer better protection and immunity than nasal sprays
McMaster University scientists who compared respiratory vaccine-delivery systems have confirmed that inhaled aerosol vaccines provide far better protection and stronger immunity than nasal sprays.
Lung capacity tests found to be accurate precursor of co-morbidities
One of the largest studies to investigate whether Preserved Ratio Impaired Spirometry (PRISm), an understudied low lung function state, is an early predictor of co-morbidities has found it is strongly associated with an increased risk of death. The analysis, led by University of Bristol researchers and published in The Lancet Respiratory Medicine, evaluated results of lung spirometry tests in over 350,000 UK adults and followed them up over 12 years.
Chemo helps breast cancer cells get their ‘foot in the door’ to the lungs
A new study adds to the evidence that chemotherapy enhances cancer’s spread beyond the primary tumor, showing how one chemo drug allows breast cancer cells to squeeze through and attach to blood vessel linings in the lungs.
Lung Ventilation after Death May Keep Organs Healthy for Transplantation for Hours
Article title: Rapid postmortem ventilation improves donor lung viability by extending the tolerable warm ischemic time after cardiac death in mice Authors: Junyi Yu, Che Xu, Janet S. Lee, Jonathan K. Alder, Zongmei Wen, Guifang Wang, Agustin Alejandro Gil Silva,…
Pulmonary Fibrosis Foundation To Launch National Walk Day
The nationwide pulmonary fibrosis (PF) community will take a collective step forward to advance research, advocacy, and awareness in the Pulmonary Fibrosis Foundation’s (PFF) National Walk Day on Saturday, Sept. 25, during Pulmonary Fibrosis Awareness Month.
Focus on “Growing Stronger” for Pulmonary Fibrosis Awareness Month in September
September is Pulmonary Fibrosis Awareness Month, presented by the Pulmonary Fibrosis Foundation (PFF) as a way to drive awareness of pulmonary fibrosis (PF), a debilitating, incurable lung disease. Learn more about the numerous endeavors intended to rejuvenate the fight against PF throughout September.
Researchers reverse emphysema in mice by injecting blood vessel wall cells
Researchers at Weill Cornell Medicine and NewYork-Presbyterian in New York have discovered that injecting mice with pulmonary endothelial cells—the cells that line the walls of blood vessels in the lung—can reverse the symptoms of emphysema. The study, which will be published July 21 in the Journal of Experimental Medicine (JEM), may lead to new treatments for chronic obstructive pulmonary disease (COPD), an inflammatory lung disease associated with smoking that is thought to be the third leading cause of death worldwide.
Molecular analysis identifies key differences in lungs of cystic fibrosis patients
A team of researchers from UCLA, Cedars-Sinai and the Cystic Fibrosis Foundation has developed a first-of-its-kind molecular catalog of cells in healthy lungs and the lungs of people with cystic fibrosis.
University of Miami Miller School of Medicine Leads Groundbreaking Trial for COVID -19 Treatment
University of Miami Miller School of Medicine researchers led a unique and groundbreaking randomized controlled trial showing umbilical cord derived mesenchymal stem cell infusions safely reduce risk of death and quicken time to recovery for the severest COVID-19 patients, according to results published in STEM CELLS Translational Medicine in January 2021.
Protein Linked to Progressive Lung Scarring in Scleroderma Patients
Osteopontin is discovered as the culprit behind these patients’ main cause of death. However, a repurposed immunosuppressive drug may combat the pro-inflammatory protein.
Lung Ultrasounds Could Help Determine COVID-19 Outcome
Researchers have developed a method using ultrasound imaging to score a patient’s lung health, which may help predict if a patient with COVID-19 will worsen. Using 14 points in the lungs, they looked for abnormalities and assigned each spot a score out of 3 based on its severity. Adding up all the points, the researchers found the total lung ultrasound score was higher for those who had a worsening outcome of COVID-19. Umberto Sabatini’s presentation will be a part of the 179th ASA Meeting of the Acoustical Society of America.
Study connects diabetes, air pollution to interstitial lung disease
A new study published in the Environmental Health Perspectives connects insulin resistance and repetitive ozone exposure to the development of interstitial lung disease.
Exercised Over Nothing: Masks Don’t Impair Lung Function During Physical Activity
A team of American and Canadian researchers report that while they may feel uncomfortable, there is little empirical evidence that wearing a facemask significantly diminishes lung function, even when worn during heavy exercise.
Pulmonary Fibrosis Foundation Launches Campaign To Raise PF Awareness And Early Diagnosis
The Pulmonary Fibrosis Foundation today announced the “Pinpoint PF” education and awareness campaign aimed at individuals with symptoms and at a higher risk for pulmonary fibrosis (PF).
Healthy Lung Month: Know these pulmonary fibrosis risk factors
October is Healthy Lung Month, an apt time to educate the public about the importance of protecting our lungs against mold, airborne pollutants and smoking – which put hundreds of thousands of Americans at higher risk for pulmonary fibrosis (PF).
Ultrasound Technique Offers More Precise, Quantified Assessments of Lung Health
Researchers have developed a technique that uses ultrasound to provide non-invasive assessments of pulmonary fibrosis and pulmonary edema. The technique has been shown to both quantify lung scarring and detect lung fluid in rats. A study on pulmonary edema in humans is under way.
Plant-Based Spray Could be Used in N95 Masks and Energy Devices
Engineers have invented a way to spray extremely thin wires made of a plant-based material that could be used in N95 mask filters, devices that harvest energy for electricity, and potentially the creation of human organs. The method involves spraying methylcellulose, a renewable plastic material derived from plant cellulose, on 3D-printed and other objects ranging from electronics to plants, according to a Rutgers-led study in the journal Materials Horizons.
International research team develops articifial lung to support pre-term babies in distress
An international team led by current and former McMaster University researchers has developed an artificial lung to support pre-term and other newborn babies in respiratory distress.
Pulmonary Fibrosis Awareness Month Highlights Realities of Rare Disease
September’s Pulmonary Fibrosis Awareness Month shares crucial realities and insights about the rare disease, its symptoms and helpful resources provided by the Pulmonary Fibrosis Foundation to educate the public about this devastating disease which impacts over 200,000 Americans.
Severely Damaged Human Lungs Can Now Be Successfully Recovered
A multidisciplinary team from Columbia Engineering and Vanderbilt University has now demonstrated that severely injured donor lungs that have been declined for transplant can be recovered outside the body by a system that uses cross-circulation of whole blood between the donor lung and an animal host. For the first time, a severely injured human lung that failed to recover using the standard clinical EVLP was successfully recovered during 24 hours on the team’s cross-circulation platform.
Ribs evolved for movement first, then co-opted for breathing
A major transformation in vertebrate evolution took place when breathing shifted from being driven by head and throat muscles—like in fish and frogs—to the torso—like in reptiles and mammals. But what caused the shift? A new study posits that the intermediate step was locomotion—the mechanics follow the same pattern as inhalation and exhalation.
COVID-19 and the Challenging Acute Respiratory Distress Syndrome (ARDS)
Joe G. N. “Skip” Garcia, MD, an academic pulmonary physician-scientist describes a complication in COVID-19.
Fibrosis or Pulmonary Fibrosis? COVID-19 Coverage Leads to Confusion
Many reports have included pulmonary fibrosis as a potential consequence of COVID-19. Data shows some COVID-19 patients develop scarring on the lungs – but not necessarily chronic pulmonary fibrosis or interstitial lung disease, which are characterized by progressive scarring.
Can Vaping Scar Your Lungs? New Insights and a Possible Remedy
Researchers report evidence that the compounds in e-cigarette liquid could potentially cause the body’s tissue repair process to go haywire and lead to scarring inside the lungs.
Breathing During Exercise Is Harder for Women Than Men
While both sexes have the capacity for phenomenal athletic achievements, women on average must work harder to breathe during strenuous exercise compared to men, according to new research.
ATS Publishes New Guidance on COVID-19 Management
An American Thoracic Society-led international task force has released a guidance document to help clinicians manage COVID-19 patients in the face of a worldwide pandemic and minimal empirical evidence to guide treatment. The new guidance – “COVID-19: Interim Guidance on Management Pending Empirical Evidence”– is published as an open access document on the American Thoracic Society’s website.