Lung Ventilation after Death May Keep Organs Healthy for Transplantation for Hours

Article title: Rapid postmortem ventilation improves donor lung viability by extending the tolerable warm ischemic time after cardiac death in mice

Authors: Junyi Yu, Che Xu, Janet S. Lee, Jonathan K. Alder, Zongmei Wen, Guifang Wang, Agustin Alejandro Gil Silva, Pablo G. Sanchez, Joseph M. Pilewski, John F. McDyer, Xingan Wang

From the authors: “Our study demonstrates that the acceptable warm ischemia time can be extended in mouse donor lungs retrieved after cardiac death by rapid ventilatory support with minimal impairments in the PaO2 /FIO2 ratio and histologic evidence of lung injury.”

This study is highlighted as one of October’s “best of the best” as part of the American Physiological Society’s APSselect program.