Scientists at Sanford Burnham Prebys Medical Discovery Institute, Camino Pharma, LLC and University of California San Diego School of Medicine have been awarded an $11.4 million grant from the National Institute on Drug Abuse (NIDA) at the National Institutes of Health (NIH) to advance a novel drug candidate for nicotine addiction into first-in-human Phase 1 studies. The drug targets a neuronal signaling pathway underlying addictive behaviors, and would be a first-in-class medication to help people quit smoking.Read more
Most doctors misperceive the risks of nicotine, the addictive chemical in tobacco products, according to a Rutgers-led national survey.Read more
Animal studies suggest that nicotine may be a key chemical responsible for long-term effects associated with maternal cigarette smoking andRead more
Researchers at Wake Forest School of Medicine have discovered that nicotine promotes the spread of lung cancer cells into the brain, where they can form deadly metastatic tumors. The study, which will be published June 4 in the Journal of Experimental Medicine (JEM), suggests that nicotine replacement therapies may not be suitable strategies for lung cancer patients attempting to quit smoking. In addition, the researchers show that the naturally occurring drug parthenolide blocks nicotine-induced brain metastasis in mice, suggesting a potential therapeutic option in humans.Read more
The use of e-cigarettes, vapes and mods have increased as smokers liken these alternatives as healthier and not having the same side effects of traditional cigarettes. Because e-cigarettes are readily available over the internet, unlike the sale of cigarettes, it perpetuates the notion that these are a safer alternative. A new study, “The New Era of Nicotine: Better for Patients?” released as part of the American Academy of Orthopaedic Surgeons’ (AAOS) Virtual Education Experience found that smokers and non-smokers believe the use of e-cigarettes and other smoking alternatives have less of an impairment on bone fracture healing than smoking traditional cigarettes, when in fact the nicotine found in both cigarettes and e-cigarettes can impede the healing process.Read more
Lactating mothers who use e-cigarettes or nicotine replacement therapies may be putting their breastfed babies at risk for skull defects, a new study in animals suggests.Read more
Findings from a new animal study suggest that maternal nicotine exposure during breastfeeding could be linked to problems with skull and face development.Read more
Misuse of prescription benzodiazepines (such as alprazolam or Xanax, and diazepam or Valium) has been linked to nicotine use. Evidence of how nicotine “sets up” a craving for benzodiazepines — often called “benzos” — in animal laboratory studies has been published in the open access journal eNeuro.Read more
Article title: COX-2 derived prostaglandins as mediators of the deleterious effects of nicotine in chronic kidney disease Authors: Sunil Rangarajan, GabrielRead more
Current policies that include restrictions on the sale of menthol flavored tobacco and nicotine products are less likely to reach those that would benefit from them the most, according to new research from the University of Kentucky’s College of Medicine.Read more
E-cigarettes — especially flavored vaping products — are becoming more popular among teens.
Vaping can cause serious health issues in teens, including e-cigarette or vaping product use-associated lung injury (EVALI), and impaired brain development. Vaping can also put teens at an increased risk of developing other addictions too.
Parents can talk with their kids about the dangers of vaping in a non-judgmental way. Pediatricians can also help by providing parents and teens with information and resources.Read more
Vaping-associated lung injury is a condition characterized by lung inflammation and damage that can lead to respiratory failure and death. Symptoms include shortness of breath, cough, and chest pain, as well as fatigue, fever, and weight loss. Many patients report gastrointestinal symptoms too.
Healthcare experts are urging people to avoid vaping because the exact cause of vaping-associated lung injury is unknown.
People who are using vaping products — especially young people, who have been most frequently affected by the condition — should closely monitor their health and seek immediate medical care if they develop symptoms.Read more