Diverse DNA signatures linked to heart disease

Risk for heart disease does not look the same on the genetic level for different population groups, report an international team of researchers this month in the journal JAMA Cardiology. The study, led by Texas Biomedical Research Institute (Texas Biomed) and Columbia University Mailman School of Public Health, begins to outline gene activity patterns that could serve as early warning indicators for cardiovascular disease.

The Latest Science on Staying Healthy During Pregnancy

Healthy habits are particularly important during pregnancy. Four new studies being presented at NUTRITION 2021 LIVE ONLINE look at how supplements, eating habits and physical activity can affect various aspects of health during pregnancy.

Study: New Approach May Boost Prostate Cancer Immunotherapies

Researchers have discovered a new way to transform the tissues surrounding prostate tumors to help the body’s immune cells fight the cancer. The discovery, made in human and mouse cells and in laboratory mice, could lead to improvements in immunotherapy treatments for prostate cancer, the second most common cancer in men in the U.S.

Mount Sinai Scientists Discover an Epigenetic Mechanism Contributing to Lifelong Stress Susceptibility

An epigenetic modification that occurs in a major cell type in the brain’s reward circuitry controls how stress early in life increases susceptibility to additional stress in adulthood, researchers at the Icahn School of Medicine at Mount Sinai have learned.

Exercise during Pregnancy Protects Kids’ Future Health from Parents’ Obesity

New research in mice suggests that exercising during pregnancy may help prevent children—especially boys—from developing health problems related to their parents’ obesity. The study is published ahead of print in the Journal of Applied Physiology. It was chosen as an APSselect article for February.

Strange colon discovery explains racial disparities in colorectal cancer

The colons of African-Americans and people of European descent age differently, new research reveals, helping explain racial disparities in colorectal cancer – the cancer that killed beloved “Black Panther” star Chadwick Boseman.

UNH Researchers Discover New Inhibitor Drug Combination for Rare Form of Cancer

Waldenström macroglobulinemia (WM), a rare form of lymphoma, does not have any known cure and only one FDA-approved treatment making it challenging to treat patients. Researchers at the University of New Hampshire took the novel approach of targeting specific cell proteins that control DNA information using inhibitors, or drugs, that were effective in reducing the growth of the cancer cells and when combined with a third drug were even more successful in killing the WM cancer cells which could lead to more treatment options.

The Novel Role of Microglia as Modulators of Neurons in the Brain Is Discovered by Mount Sinai Researchers

Findings offer potential target for treating behavioral abnormalities associated with neurodegenerative conditions like Alzheimer’s Disease

Center for Alcohol Research in Epigenetics at UIC receives $8M from NIH

The University of Illinois at Chicago received $8.2 million from the National Institute on Alcohol Abuse and Alcoholism to continue the Center for Alcohol Research in Epigenetics and its research on how alcohol affects genes through epigenetics — chemical changes to DNA, RNA or proteins that alter the expression of genes without directly modifying them.

Diabetes Drug May Protect Breastfed Sons from Future Metabolic Disorder

Article title: Lactational metformin exposure programs offspring white adipose tissue glucose homeostasis and resilience to metabolic stress in a sex-dependent manner Authors: Zach Carlson, Hannah Hafner, Molly Mulcahy, Kaylie Bullock, Allen Zhu, Dave Bridges, Ernesto Bernal-Mizrachi, Brigid Gregg From the authors: “Future…

A Novel Class of Long Non-coding RNAs May Help Explain Increased Susceptibility of Females to Depression

Researchers at Mount Sinai have found that a novel class of genes known as long non-coding RNAs (lncRNAs) expressed in the brain may play a pivotal role in regulating mood and driving sex-specific susceptibility versus resilience to depression.

First Molecular Test in US to Better Detect Brain Tumors Now Available to Patients

NYU Langone Health and its Perlmutter Cancer Center have launched clinical whole genome DNA methylation profiling for patients with brain tumors.
This leading-edge molecular assay utilizes DNA epigenetic signatures and artificial intelligence with machine learning to correctly identify and subtype brain tumors. NYU Langone Health is the first Clinical Laboratory Improvement Amendments (CLIA)-certified laboratory in the United States to receive state approval (New York State Department of Health) for whole genome DNA methylation for diagnosis and classification of brain tumors.