Enzyme, proteins work together to tidy up tail ends of DNA in dividing cells

Researchers at the University of Wisconsin–Madison have described the way an enzyme and proteins interact to maintain the protective caps, called telomeres, at the end of chromosomes, a new insight into how a human cell preserves the integrity of its DNA through repeated cell division. DNA replication is essential for perpetuating life as we know it, but many of the complexities of the process — how myriad biomolecules get where they need to go and interact over a series of intricately orchestrated steps — remain mysterious.

Stress during Pregnancy May Lead to Heart Disease, Accelerated Aging in Next Generation

Prenatal stress can cause damage in the aorta in offspring, which may contribute to the development of atherosclerosis and accelerate aging, according to a new study in mice. The article is published ahead of print in the American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.