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UrduAs an associate professor at Sanford Burnham Prebys, Dhar focuses on how lifestyle factors such as high-calorie diets, excessive alcohol consumption and minimal exercise—along with genetic predispositions—can lead to problematic changes in the liver, heart and kidneys. By studying the conversation among the liver, the immune system, heart and kidneys, Dhar hopes to discover signals that could be used to detect metabolic disorders, especially metabolic-associated steatohepatitis (MASH), and liver cancer much earlier, when they’re easier to treat.
Tag: Metabolic Disorder
Succinate Protects against Obesity, Metabolic Disease through Brown Fat Protein Expression
Article title: Exogenous succinate impacts mouse brown adipose tissue mitochondrial proteome and potentiates body mass reduction induced by liraglutide Authors: Rodrigo S. Gaspar, Jeany Delafiori, Giuliana Zuccoli, Victor Corasolla Carregari, Thais P. Prado, Joseane Morari, Davi Sidarta-Oliveira, Carina S. Solon,…
Tufts University Scientists Identify Brain Pathway Connected to Hunger and Overeating
Scientists at Tufts University have discovered a pathway through which communications are regulated in the brain, and a misfire in the messaging can result in overeating, slower burning of calories, and other metabolic problems linked to obesity.
COVID-19 Patients Have Impaired Mitochondrial and Metabolic Function
Article title: Mitochondrial metabolic manipulation by SARS-CoV-2 in peripheral blood mononuclear cells of COVID-19 patients Authors: Saima Ajaz, Mark J. McPhail, Keshav K. Singh, Salma Mujib, Francesca M. Trovato, Salvatore Napoli, Kosh Agarwal From the authors: “Our study identifies the…
Diabetes Drug May Protect Breastfed Sons from Future Metabolic Disorder
Article title: Lactational metformin exposure programs offspring white adipose tissue glucose homeostasis and resilience to metabolic stress in a sex-dependent manner Authors: Zach Carlson, Hannah Hafner, Molly Mulcahy, Kaylie Bullock, Allen Zhu, Dave Bridges, Ernesto Bernal-Mizrachi, Brigid Gregg From the authors: “Future…