New Penn Medicine Study Uncovers Key Details of Fat Cells, Advancing Potential Treatments for Obesity, Diabetes

New research has unlocked insights into how “good fat” tissue could potentially be harnessed to combat obesity and remove glucose from the blood, helping to control diabetes. Published today in Science Advances, the work is a collaboration between researchers with the Perelman School of Medicine at the University of Pennsylvania and University of Cambridge, Free University of Brussels and University of East Anglia.

Succinate Protects against Obesity, Metabolic Disease through Brown Fat Protein Expression

Article title: Exogenous succinate impacts mouse brown adipose tissue mitochondrial proteome and potentiates body mass reduction induced by liraglutide Authors: Rodrigo S. Gaspar, Jeany Delafiori, Giuliana Zuccoli, Victor Corasolla Carregari, Thais P. Prado, Joseane Morari, Davi Sidarta-Oliveira, Carina S. Solon,…

Vitamin B5 May Help Weight Loss by Turning on Brown Fat

Pantothenate acid, also known as vitamin B5, stimulated the production of brown fat in both cell cultures and mice, a new study finds. “[B5] has therapeutic potential for treating obesity and type II diabetes,” researchers conclude. The study was chosen as an APSselect article for July.

Pain receptors linked to the generation of energy-burning fat cells: implications for obesity therapy

A new source of energy expending brown fat cells has been uncovered by researchers at the Joslin Diabetes Center, which they say points towards potential new therapeutic options for obesity. According to the new report, published in Nature Metabolism >on 12 March 2021, the key lies in the expression of a receptor called Trpv1 (temperature-sensitive ion channel transient receptor potential cation subfamily V member 1) — a protein known to sense noxious stimuli, including pain and temperature.

Study Explores Regulatory Role for White Blood Cells in Recruitment of Brown Fat

Article title: Thermogenic recruitment of brown and brite/beige adipose tissues is not obligatorily associated with macrophage accretion or attrition Authors: Nathalie Boulet, Ineke H.N. Luijten, Barbara Cannon, Jan Nedergaard From the authors: “A regulatory or mediatory role—positive or negative—for macrophages…