Why women may be more susceptible to Alzheimer’s disease

Case Western Reserve University researchers have identified a mechanism in brain tissue that may explain why women are more vulnerable to Alzheimer’s disease—a finding that they say could help lead to new medicines to treat the disease. The researchers found that the female brain shows higher expression of a certain enzyme compared to males, resulting in greater accumulation of a protein called tau.

Scientists See Signs of Traumatic Brain Injury in Headbutting Muskox

Scientists at the Icahn School of Medicine at Mount Sinai saw for the first time hallmarks of concussions and other head trauma in the brains of deceased headbutting animals—muskoxen and bighorn sheep. The results published in the journal Acta Neuropathologica may contradict the commonly-held belief that ramming animals do not suffer brain injuries and support the notion that studies on animals with brains evolutionarily similar to those of humans may help researchers understand and reduce traumatic brain injuries.

Will reduction in tau protein protect against Parkinson’s and Lewy body dementias?

A study suggests that reducing tau protein in brain neurons will not protect against Parkinson’s disease and Lewy body dementias. If borne out, this result differs from Alzheimer’s disease, where reducing endogenous tau levels in brain neurons is protective for multiple models of the disease.

New Case Western Reserve University study identifies novel mechanisms that cause protein clumping in Alzheimer’s and other degenerative brain diseases

A team of researchers at the Case Western Reserve University School of Medicine has taken a major step toward understanding the mechanisms involved in the formation of large clumps of tau protein, a hallmark of Alzheimer’s disease and several other neurodegenerative disorders.

People with Heroin Addiction Have Unique Molecular Alterations to The Brain That Resemble Brain Disturbances Seen in Neurodegenerative Disorders Like Alzheimer’s Disease

MEDIA ADVISORY   FOR IMMEDIATE RELEASE: Nature Communications:  Published Monday, September 14, 2020 Corresponding Author: Yasmin Hurd, PhD, Director of The Addiction Institute of Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, and other coauthors. Bottom Line: Herion-addicted individuals have…