Studies on Higher Infliximab Concentrations in IBD, Opioid-Related Constipation and More in the November Issue of AJG

The November issue of AJG highlights new clinical science and reviews including additional colonoscopy quality measures, higher infliximab concentrations in IBD patients with higher visceral adipose tissue (VAT), an automated tissue systems pathology test for Barrett’s esophagus, and opioid-related constipation.

Digital Therapeutics and Innovations in GI Highlighted in the August Issue of AJG

The August issue of The American Journal of Gastroenterology includes several articles on digital therapeutics and innovations in GI, encouraging adoption of emerging GI technologies to advance GI care.

Smartphone App to Assess Stool Form, Rural-Urban Disparities in Cirrhosis Mortality, Lung Infection Risk in Severe Alcoholic Hepatitis in July Issue of AJG

The July issue of The American Journal of Gastroenterology highlights new clinical science including using a smartphone app to assess stool form, rural-urban disparities in cirrhosis mortality, and lung infection risk in severe alcohol-related hepatitis. This issue also includes articles on pediatric IBD, therapy options for Crohn’s disease, a novel endoscopic suturing device, proton pump inhibitors, and more.

November Issue of The American Journal of Gastroenterology Discusses Association Between BMI and Early-Onset Colorectal Cancer Risk, PPIs and All-Cause Mortality

The November issue of The American Journal of Gastroenterology features several articles examining the association between common conditions or treatments and the risk for disease development, including a study on the association between higher body mass index and increased risk for early-onset colorectal cancer, and a population study on proton pump inhibitors and all-cause mortality.

Mount Sinai Launches the Brain and Body Research Center, Among the First in the U.S.to Focus Solely on How the Brain and Body Interact

Have you ever experienced a stressful time in your life and then caught a cold, or wondered why you feel sad and depressed when you’re sick? It turns out that it’s not all in your head.

Recent research spanning the fields of neuroscience and immunology suggests that when the brain senses a threat in the environment—whether it be physical, psychological, or social—it sends signals via a complex network of peripheral nerves that mobilize the immune system, readying it to protect us from injury.

July Issue of The American Journal of Gastroenterology Includes Analysis of Psychological Comorbidities and Irritable Bowel Syndrome Prognosis

The July issue of AJG includes an examination of psychological comorbidities and the prognosis of individuals with IBS, as well as clinical research and reviews on cirrhosis, GERD, pediatrics, celiac disease, probiotics, GI quality improvement, NASH, and more.

Irritable Bowel Syndrome: Mark Pimentel, MD

Irritable bowel syndrome (IBS) is the most common gastrointestinal disorder, affecting 10-15% of the world’s population. Approximately two-thirds of those who suffer from IBS are women. The disease can have mild forms or cause severe debilitation as diarrhea alternates with constipation. Severe cramping and bloating also are common. Because chronic IBS is so debilitating, it often disrupts the daily lives of people with this disorder.

Open-Label (Honest) Placebo Works as Well as Double-Blind Placebo in Irritable Bowel Syndrome

In a randomized clinical trial published in the journal PAIN, researchers found participants with moderate to severe irritable bowel syndrome (IBS) who were knowingly treated with a pharmacologically inactive pill — referred to as an honest or open-label placebo — reported clinically meaningful improvements in their IBS symptoms.

The American College of Gastroenterology Issues Its First Clinical Guideline on Management of Irritable Bowel Syndrome

The new guideline recommends is a positive diagnostic strategy involving a careful history, physical examination, and limited diagnostic testing, which can substantially shorten time to appropriate therapy and be more cost-effective for patients.

High-fat diet with antibiotic use linked to gut inflammation

UC Davis researchers have found that combining a Western-style high-fat diet with antibiotic use significantly increases the risk of developing pre- inflammatory bowel disease. This combination shuts down the mitochondria in cells of the colon lining, leading to gut inflammation. Mesalazine can help restart the mitochondria and treat pre-IBD condition.

CHOP Researchers Develop Novel Approach to Capture Hard-to-View Portion of Colon in 3-D for the First Time

In a groundbreaking discovery, researchers at Children’s Hospital of Philadelphia (CHOP) developed a new imaging method that allows scientists to view the enteric nervous system (ENS) – a key part of the human colon – in three dimensions by making other colon cells that normally block it invisible. The ENS has previously only been visible in thin tissue slices that provide limited clinical information.