Strong immune response underlies acute kidney injury related to COVID-19

Mayo Clinic researchers have found that acute kidney injury associated with COVID-19 resembles sepsis-caused kidney injury, and the immune response triggered by the infection plays a pivotal role.

The findings, published in Mayo Clinic Proceedings, also suggest that mitochondrial dysfunction — a loss of function in cellular energy production — is commonly found in kidney injury related to COVID-19.

Surprise Discovery Shows Chronic Heart Dysfunction Protects against Acute Kidney Injury

Article title: Activation of hypoxia-sensing pathways promotes renal ischemic preconditioning following myocardial infarction Authors: Andrew S. Terker, Kensuke Sasaki, Juan Pablo Arroyo, Aolei Niu, Suwan Wang, Xiaofeng Fan, Yahua Zhang, Sochinwechi Nwosisi, Ming-Zhi Zhang, Raymond C. Harris From the authors:…

High risk of acute kidney injury in patients undergoing treatment for infected total knee replacements

Acute kidney injury (AKI) occurred in nearly 20 percent of patients who underwent surgery with implantation of antibiotic-loaded “spacers” and intravenous (IV) antibiotics for the treatment of deep infections after total knee arthroplasty, reports a study in The Journal of Bone & Joint Surgery. The journal is published in the Lippincott portfolio in partnership with Wolters Kluwer.

Research News Tip Sheet: Story Ideas from Johns Hopkins Medicine

During the COVID-19 pandemic, Johns Hopkins Medicine Media Relations is focused on disseminating current, accurate and useful information to the public via the media. As part of that effort, we are distributing our “COVID-19 Tip Sheet: Story Ideas from Johns Hopkins” every other Wednesday.

Kidney Injury in Diabetic Ketoacidosis Linked to Brain Injury

Researchers have identified factors that make children with diabetic ketoacidosis more likely to experience acute kidney injury. Analyzing data from a large, multicenter clinical trial, the researchers also found that children who experience acute kidney injury are more likely to also experience subtle cognitive impairment and demonstrate lower IQ scores, suggesting a pattern of multiple organ injury.

Enzyme Activation after Acute Kidney Injury May Lead to Tubule Atrophy

Article title: Intratubular epithelial-mesenchymal transition and tubular atrophy after kidney injury in mice Authors: Noriyuki Yamashita, Tetsuro Kusaba, Tomohiro Nakata, Aya Tomita, Tomoharu Ida, Noriko Watanabe-Uehara, Kisho Ikeda, Takashi Kitani, Masahiro Uehara, Yuhei Kirita, Satoaki Matoba, Benjamin D. Humphreys, Keiichi Tamagaki From…

Xenobiotic Receptor Activation, CRISPR/Cas9, Magnetic Resonance-Guided Radiotherapy, and More Featured in May 2020 Toxicological Sciences

During these difficult times, the Society of Toxicology’s official journal, Toxicological Sciences, remains a source for leading research in toxicology, including in the areas of biomarkers, carcinogenesis, and organ-specific toxicology.

Vinyl Chloride, Nerve Growth Factor, Chemical Warfare, and More Examined in March 2020 Toxicological Sciences

The March 2020 issue of Toxicological Sciences features leading research in toxicology, covering investigations in biotransformation, toxicokinetics, and pharmacokinetics in addition to work in exposure sciences and environmental toxicology.

AMERICAN SOCIETY OF NEPHROLOGY LAUNCHES NEW INITIATIVE THAT AIMS TO SAVE LIVES FOR PEOPLE SUFFERING WITH ACUTE KIDNEY INJURY

The American Society of Nephrology (ASN) recently launched a new initiative aimed at saving lives of those who suffer from acute kidney injury (AKI). Made possible by a grant from Baxter Healthcare Corporation, the effort is called AKI!Now: Promoting Excellence in the Prevention and Treatment of Acute Kidney Injury.

American Physiological Society (APS)

Low Dose of Bacterial Toxin Could Be Protective for Men at Risk of Acute Kidney Injury

Lipopolysaccharide improved outcomes for male, but not female, rats Charlottesville, Va. (June 25, 2019)—In a counterintuitive result, researchers found that giving male rats a low dose of the endotoxin lipopolysaccharide (LPS) prior to inducing a model of acute kidney injury…