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UrduArticle title: Distinct developmental reprogramming footprint of macrophages during acute kidney injury across species Authors: Michal Mrug, Elias Mrug, Frida Rosenblum, Jiandong Chen, Xiangqin Cui, Anupam Agarwal, Abolfazl Zarjou From the authors: “Our findings identify robust acute kidney injury (AKI)-induced…
Tag: Acute Kidney Injury
Acute kidney injury not associated with worsening kidney function in persons with CKD
A study of hospitalized persons with chronic kidney disease (CKD) fournd that acute kidney injury (AKI) did not predict worsening of kidney function trajectory once difference in pre-hospitalization characteristically were fully accounted for. Instead, the authors suggest that much of determinants of faster kidney disease decline observed after AKI may already be present before AKI. The findings are published in Annals of Internal Medicine.
Drug discovery offers potential treatment for common kidney disease
A serious condition that can cause the kidneys to suddenly stop working could be treated with existing medicines, a new study shows.
First Ever in Pediatrics: World Experts Set Agenda to Improve Care of Acute Kidney Injury in Kids
First pediatric international conference on acute kidney injury (AKI) resulted in an expert consensus statement published in the journal JAMA Network Open. In this milestone publication, 46 global experts identify key issues in pediatric AKI and set a focused research agenda for the next five to 10 years.
Past Kidney Disease May Increase Preeclampsia Risk, Impair Blood Vessel Health during Pregnancy
A history of kidney problems may put people at a higher risk for impaired blood vessel function, which could lead to high blood pressure, preterm labor and other adverse outcomes, according to the results of a study in rats. The researchers will present their work this week at the American Physiological Society (APS) and American Society for Nephrology Control of Renal Function in Health and Disease conference in Charlottesville, Virginia.
Coffee consumption linked to reduced risk of acute kidney injury, study finds
A recent study by Johns Hopkins Medicine researchers has revealed that consuming at least one cup of coffee a day may reduce the risk of acute kidney injury (AKI) when compared to those who do not drink coffee.
Mount Sinai Cardiologist Develops New Risk Score to Help Predict Possible Contrast-Associated Kidney Injury After Percutaneous Coronary Intervention
Assessment can help stratify high-risk patients for monitoring before, during, and after procedures to improve outcomes
Combining Melatonin with Vancomycin Reduces Kidney Failure
A study by researchers at the Rutgers Ernest Mario School of Pharmacy finds that melatonin significantly reduces kidney failure in people being treated with the antibiotic vancomycin.
Strong immune response underlies acute kidney injury related to COVID-19
Mayo Clinic researchers have found that acute kidney injury associated with COVID-19 resembles sepsis-caused kidney injury, and the immune response triggered by the infection plays a pivotal role.
The findings, published in Mayo Clinic Proceedings, also suggest that mitochondrial dysfunction — a loss of function in cellular energy production — is commonly found in kidney injury related to COVID-19.
Kidney Injury Increases Oxidative Stress, Depletes Energy Production in Lungs
Article title: Lung metabolomics after ischemic acute kidney injury reveals increased oxidative stress, altered energy production and ATP depletion Authors: Sophia L. Ambruso, Hyo-Wook Gil, Benjamin Fox, Bryan Park, Christopher Altmann, Rushita A. Bagchi, Peter R. Baker II, Julie A.…
Surprise Discovery Shows Chronic Heart Dysfunction Protects against Acute Kidney Injury
Article title: Activation of hypoxia-sensing pathways promotes renal ischemic preconditioning following myocardial infarction Authors: Andrew S. Terker, Kensuke Sasaki, Juan Pablo Arroyo, Aolei Niu, Suwan Wang, Xiaofeng Fan, Yahua Zhang, Sochinwechi Nwosisi, Ming-Zhi Zhang, Raymond C. Harris From the authors:…
High risk of acute kidney injury in patients undergoing treatment for infected total knee replacements
Acute kidney injury (AKI) occurred in nearly 20 percent of patients who underwent surgery with implantation of antibiotic-loaded “spacers” and intravenous (IV) antibiotics for the treatment of deep infections after total knee arthroplasty, reports a study in The Journal of Bone & Joint Surgery. The journal is published in the Lippincott portfolio in partnership with Wolters Kluwer.
Research News Tip Sheet: Story Ideas from Johns Hopkins Medicine
During the COVID-19 pandemic, Johns Hopkins Medicine Media Relations is focused on disseminating current, accurate and useful information to the public via the media. As part of that effort, we are distributing our “COVID-19 Tip Sheet: Story Ideas from Johns Hopkins” every other Wednesday.
Kidney Injury in Diabetic Ketoacidosis Linked to Brain Injury
Researchers have identified factors that make children with diabetic ketoacidosis more likely to experience acute kidney injury. Analyzing data from a large, multicenter clinical trial, the researchers also found that children who experience acute kidney injury are more likely to also experience subtle cognitive impairment and demonstrate lower IQ scores, suggesting a pattern of multiple organ injury.
Enzyme Activation after Acute Kidney Injury May Lead to Tubule Atrophy
Article title: Intratubular epithelial-mesenchymal transition and tubular atrophy after kidney injury in mice Authors: Noriyuki Yamashita, Tetsuro Kusaba, Tomohiro Nakata, Aya Tomita, Tomoharu Ida, Noriko Watanabe-Uehara, Kisho Ikeda, Takashi Kitani, Masahiro Uehara, Yuhei Kirita, Satoaki Matoba, Benjamin D. Humphreys, Keiichi Tamagaki From…
Uncovering a ‘suPAR’ culprit behind kidney injury in COVID-19
A new observational study finds patients in the hospital for COVID-19 have high levels of soluble urokinase receptor (suPAR), an immune-derived pathogenic protein that is strongly predictive of kidney injury.
Xenobiotic Receptor Activation, CRISPR/Cas9, Magnetic Resonance-Guided Radiotherapy, and More Featured in May 2020 Toxicological Sciences
During these difficult times, the Society of Toxicology’s official journal, Toxicological Sciences, remains a source for leading research in toxicology, including in the areas of biomarkers, carcinogenesis, and organ-specific toxicology.
Vinyl Chloride, Nerve Growth Factor, Chemical Warfare, and More Examined in March 2020 Toxicological Sciences
The March 2020 issue of Toxicological Sciences features leading research in toxicology, covering investigations in biotransformation, toxicokinetics, and pharmacokinetics in addition to work in exposure sciences and environmental toxicology.
Marathoners, Take Your Marks … and Fluid and Salt!
Legend states that after the Greek army defeated the invading Persian forces near the city of Marathon in 490 B.C.E., the courier Pheidippides ran to Athens to report the victory and then immediately dropped dead.
AMERICAN SOCIETY OF NEPHROLOGY LAUNCHES NEW INITIATIVE THAT AIMS TO SAVE LIVES FOR PEOPLE SUFFERING WITH ACUTE KIDNEY INJURY
The American Society of Nephrology (ASN) recently launched a new initiative aimed at saving lives of those who suffer from acute kidney injury (AKI). Made possible by a grant from Baxter Healthcare Corporation, the effort is called AKI!Now: Promoting Excellence in the Prevention and Treatment of Acute Kidney Injury.
Low Dose of Bacterial Toxin Could Be Protective for Men at Risk of Acute Kidney Injury
Lipopolysaccharide improved outcomes for male, but not female, rats Charlottesville, Va. (June 25, 2019)—In a counterintuitive result, researchers found that giving male rats a low dose of the endotoxin lipopolysaccharide (LPS) prior to inducing a model of acute kidney injury…
Restrictive Approach to Blood Cell Transfusions Safe for Heart Surgery Patients
Strategy led to fewer transfusions without any risk to kidney health. Highlights A restrictive approach to blood cell transfusions in patients undergoing cardiopulmonary bypass surgery led to fewer transfusions than a more liberal approach, without any increased risk of acute…