Enzyme Activation after Acute Kidney Injury May Lead to Tubule Atrophy

Article title: Intratubular epithelial-mesenchymal transition and tubular atrophy after kidney injury in mice

Authors: Noriyuki Yamashita, Tetsuro Kusaba, Tomohiro Nakata, Aya Tomita, Tomoharu Ida, Noriko Watanabe-Uehara, Kisho Ikeda, Takashi Kitani, Masahiro Uehara, Yuhei Kirita, Satoaki Matoba, Benjamin D. Humphreys, Keiichi Tamagaki

From the authors: “The main finding of our study was that [focal adhesion kinase] activation in proximal tubules after [acute kidney injury] induces a maladaptive proliferative state leading to tubule atrophy.” 

This study is highlighted as one of October’s “best of the best” as part of the American Physiological Society’s APSselect program.