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UrduResearchers at Memorial Sloan Kettering Cancer Center (MSKCC) in New York have discovered that common cancer treatments, such as radiotherapy or anthracycline drugs, cause long-term damage to heart tissue by activating a key inflammatory signaling pathway. The study, published December 19 in the Journal of Experimental Medicine (JEM), suggests that inhibiting this pathway could reduce the chances of cancer survivors suffering heart disease later in life.
Tag: Radiotherapy
ASTRO issues updated guideline on radiation therapy for endometrial cancer
A newly updated clinical guideline from the American Society for Radiation Oncology (ASTRO) provides recommendations on the use of radiation therapy and systemic therapy after surgery to treat patients with endometrial cancer. The guideline also considers the role of surgical staging and molecular profiling techniques in determining whether a patient should receive post-operative therapy. The guideline is published in the January/February 2023 issue of Practical Radiation Oncology.
From Qubits to Potential Cancer Treatments: Laser Upgrade Opens New Research Possibilities
Things are looking brighter than ever at the Berkeley Lab Laser Accelerator Center. A recently completed upgrade will expand the center’s capabilities into new areas, including studies of particle acceleration, extremely hot plasmas, cancer treatment techniques, and materials for quantum science.
November 2022 Issue of Neurosurgical Focus: “Evolution of Radiation Therapy Technique”
Announcement of contents of the November 2022 issue of Neurosurgical Focus
Radiation-hormone therapy combination may slow growth of oligometastatic prostate cancer
A new study offers a new option to patients with oligometastatic prostate cancer who want relief from hormone therapy without compromising the risk of their disease spreading. In the study, patients who received radiation in addition to intermittent hormone therapy lived longer without their disease progressing, and they were able to take longer breaks from the drug treatments. Results of the phase II trial (EXTEND; NCT03599765) will be presented today at the American Society for Radiation Oncology (ASTRO) Annual Meeting.
Adding radiation to systemic therapy extends overall survival for patients with advanced liver cancer
Adding radiation therapy to systemic therapy for patients with advanced liver cancer can extend overall survival and delay tumor progression without compromising patients’ quality of life, a randomized phase III clinical trial shows.
Radiation therapy for high-risk, asymptomatic bone metastases may prevent pain and prolong life
Treating high-risk, asymptomatic bone metastases with radiation may reduce painful complications and hospitalizations and possibly extend overall survival in people whose cancer has spread to multiple sites, a phase II clinical trial suggests. Results of the multicenter, randomized trial (NCT03523351) will be presented today at the American Society for Radiation Oncology (ASTRO) Annual Meeting.
Medical physicist consults with patients can help reduce anxiety and increase satisfaction with radiation care
Meeting with a medical physicist who can explain how radiation therapy is planned and delivered reduces patient anxiety and increases patient satisfaction throughout the treatment process, according to a new study published today in the International Journal of Radiation Oncology • Biology • Physics. Findings of the randomized, prospective phase III clinical trial also will be presented at the American Society for Radiation Oncology (ASTRO) Annual Meeting.
FLASH radiation therapy shows promise in first-in-human trial
FLASH radiation treatment – which delivers therapeutic doses of radiation in a fraction of a second – may hold promise as a potential treatment for tough-to-kill tumors, a first-in-human study in a small number of people with bone cancer suggests.
Shortened course of radiation therapy safe and effective for men with high-risk prostate cancer
A new randomized study confirms that men with high-risk prostate cancer can be treated with five versus eight weeks of radiation therapy.
Sexual side effects of cancer treatment often unaddressed with female patients
A new study finds that sexual side effects of cancer treatment are discussed far less frequently with female patients than with male patients, even when the treatment directly affects sex organs.
Radiation oncology research and clinical trial results to be featured at ASTRO’s Annual Meeting in San Antonio
The American Society for Radiation Oncology (ASTRO) announced today the 10 studies that will be highlighted in the 2022 ASTRO Annual Meeting press program. Researchers will discuss their findings in two news briefings to be held October 24 and 25 in the Henry B. Gonzalez Convention Center in San Antonio and via live webcast. Reporters can register for the meeting at astro.org/annualmeetingpress.
MD Anderson Research Highlights for September 28, 2022
The University of Texas MD Anderson Cancer Center’s Research Highlights provides a glimpse into recent basic, translational and clinical cancer research from MD Anderson experts. Current advances include an investigation into the efficacy of dexamethasone for dyspnea relief, a combination therapy for hairy cell leukemia, an analysis of RAS mutations and their prognostic value in acute myeloid leukemia (AML), a possible new combination therapy for basal-like breast cancer, and swallowing exercises to improve the quality of life for patients with head and neck cancer undergoing radiotherapy.
Anti-sedative could alleviate cancer therapy side effects, study suggests
Researchers in China have discovered that inhibiting a protein called the GABAA receptor can protect intestinal stem cells from the toxic effects of chemotherapy and radiotherapy. The study, published September 20 in the Journal of Experimental Medicine (JEM), suggests that the FDA-approved anti-sedative flumazenil, which targets GABAA receptors, could alleviate some of the common gastrointestinal side effects, such as diarrhea and vomiting, induced by many cancer treatments.
ASTRO issues clinical guideline on radiation therapy for IDH-mutant glioma
A new clinical guideline from the American Society for Radiation Oncology (ASTRO) provides recommendations on the use of radiation therapy to treat patients with isocitrate dehydrogenase (IDH)-mutant grade 2 and grade 3 diffuse glioma. Evidence-based recommendations outline the multidisciplinary planning and delivery techniques to manage this subset of central nervous system (CNS) tumors.
Traditional Chinese medicine reduces side effect of cancer treatment
For tens of thousands of Australians who receive radiotherapy as part of their cancer treatment, mucositis is a serious side effect that may cause inflammation, ulcers, diarrhoea, nausea and vomiting, abdominal pain and bloating. Currently there is no effective treatment for mucositis, but researchers from the University of Adelaide have found that a type of traditional Chinese medicine reduces the severity of radiation-induced gastrointestinal mucositis (GIM) in rats.
Radiotherapy not always needed for early breast cancer
McMaster researchers tracked 501 patients with luminal A breast cancer for five years post-surgery and found the recurrence of cancer in the breast was just 2.3 per cent without radiotherapy. This was roughly comparable with a 1.9 per cent risk this patient sample had of developing a new breast cancer in their other untreated breast.
High-dose radiation thwarts tumor growth in patients with advanced lung cancer
High-dose radiation therapy can be used to lengthen progression-free survival for people with advanced lung cancer when systemic therapy has not fully halted the growth or spread of metastases, according to a new study. Findings will be presented today at the American Society for Radiation Oncology (ASTRO) Annual Meeting.
External-beam radiation therapy underused for people with liver cancer awaiting transplant
People with liver cancer awaiting transplantation could benefit from non-invasive radiation treatments but are rarely given this therapy, according to a new analysis of U.S. national data. Findings will be presented today at the American Society for Radiation Oncology (ASTRO) Annual Meeting.
ASTRO issues clinical guideline on radiation therapy for soft tissue sarcoma in adults
A new clinical guideline from the American Society for Radiation Oncology (ASTRO) provides guidance on radiation therapy for soft tissue sarcoma. Recommendations outline optimal radiation dosing, techniques and treatment planning, with a focus on preserving long-term functionality through individualized care.
ASTRO responds to troubling Medicare cuts and Radiation Oncology Model update
In response to consecutive weeks of significant proposed Medicare payment cuts to radiation oncology cancer care, Thomas J. Eichler, MD, Chair of American Society for Radiation Oncology (ASTRO), issued the following statement.
American Society for Radiation Oncology (ASTRO) to host in-person Annual Meeting in Chicago, October 24-27
Registration opens today for the American Society for Radiation Oncology’s (ASTRO) 63rd Annual Meeting, which will return to an in-person conference at McCormick Place West in Chicago, October 24-27, 2021. Media resources and registration are available at www.astro.org/astro2021press, and general registration is available at www.astro.org/annualmeeting.
COVID-19 pandemic has led to more advanced-stage cancer diagnoses, physician survey finds
Doctors who oversee cancer clinics say that new patients are arriving for treatment with more advanced disease than before the COVID-19 pandemic, according to a new survey from the American Society for Radiation Oncology (ASTRO). The survey fielded in early 2021 also found that treatment postponements and deferrals have largely subsided.
Ludwig Cancer Research Study Reveals How Certain Gut Bacteria Compromise Radiotherapy
A study led by Ludwig Chicago Co-director Ralph Weichselbaum and Yang-Xin Fu of the University of Texas Southwestern Medical Center has shown how bacteria in the gut can dull the efficacy of radiotherapy, a treatment received by about half of all cancer patients.
Is proton therapy the silver bullet for children with brain cancer?
How safe is proton therapy for children with brain cancer compared to the conventional x-ray radiation delivered post-surgery?
Exercise May Improve Effects of Radiation Therapy in Prostate Cancer
Cancer is the second leading cause of death around the world after heart disease. This week, researchers exploring the effects of exercise as a natural preventive tool and noninvasive treatment for cancer will present their work at the American Physiological Society (APS) Integrative Physiology of Exercise conference.
Adding image guidance to post-operative radiation therapy can reduce side effects for women with cervical cancer
A phase III trial from India shows that an advanced radiation therapy technique leads to fewer gastrointestinal side effects in women who receive radiation after undergoing hysterectomy for cervical cancer. Findings from the PARCER trial (NCT01279135) will be presented today at the American Society for Radiation Oncology (ASTRO) Annual Meeting.
Group trial bolsters case for stereotactic radiation therapy for tumors that travel to the lungs
A new study, conducted across 13 medical centers in Australia and New Zealand, strengthens the case for radiation therapy as a treatment for cancer that has begun to spread throughout the body. Findings of the SAFRON II trial (NCT01965223) will be presented today at the American Society for Radiation Oncology (ASTRO) Annual Meeting.
Treating spinal metastases with fewer and higher doses of radiation reduces pain more effectively
A new study shows using fewer and higher doses of high-precision radiation therapy is a more effective approach for treating painful spinal tumors than conventional radiation therapy. Findings from the Canadian phase II/III trial (NCT02512965) will be presented today at the American Society for Radiation Oncology (ASTRO) Annual Meeting.
Radiosurgery reduces cognitive decline without compromising survival for patients with 4+ brain metastases
Results of a new randomized phase III trial suggest that stereotactic radiosurgery (SRS) should replace whole brain radiation therapy (WBRT) as the standard of care for patients with four or more brain metastases. Results from the clinical trial (NCT01592968) will be presented today at the American Society for Radiation Oncology (ASTRO) Annual Meeting.
Adding advanced PET scans to radiation treatment plans for prostate cancer increases failure-free survival rates
Adding the advanced PET radiotracer fluciclovine to conventional imaging to help guide radiation treatments for recurrent prostate cancer can improve disease-free survival rates, a new study finds. Findings from the randomized phase II/III EMPIRE-1 trial (NCT01666808) will be presented today at the American Society for Radiation Oncology (ASTRO) Annual Meeting.
Expert Alert: Accelerated breast cancer treatments at Mayo Clinic provide more options for patients during pandemic
Radiation therapy for breast cancer can be grueling and disruptive, stretching out for as long as five to seven weeks, and often requiring extended time off from work or away from home. But research over the past decade, as well as new technology and innovations at Mayo Clinic, has led to treatment alternatives that are shorter, more targeted and just as effective.
ASTRO issues clinical guideline on radiation therapy for rectal cancer
A new clinical guideline from the American Society for Radiation Oncology (ASTRO) provides guidance for physicians who use radiation therapy to treat patients with locally advanced rectal cancer. Recommendations outline indications and best practices for pelvic radiation treatments, as well as the integration of radiation with chemotherapy and surgery for stage II-III disease. The guideline, which replaces ASTRO’s 2016 guidance for rectal cancer, is published in Practical Radiation Oncology.
Radiation oncology research and clinical trial results to be featured at ASTRO’s Annual Meeting
The American Society for Radiation Oncology (ASTRO) announced today the press program for its 2020 Annual Meeting, which will feature studies on cancer treatment advances and discussions of topical issues including COVID-19. Researchers will present their findings via live webcasts on October 26 and 27. Register for press access at www.astro.org/annnualmeetingpress.
Inhibiting Key Molecular Chaperone Sensitives Tumors to Radiation Therapy in Animal Models
While heat shock protein 90 inhibitors have shown limited benefit in directly treating cancer, low doses may improve the efficacy of radiotherapy, a new study finds.
American Society for Radiation Oncology (ASTRO) to host virtual Annual Meeting, October 25-28
The American Society for Radiation Oncology’s (ASTRO) 62nd Annual Meeting, will be held October 25-28 via an interactive virtual platform. The meeting, Global Oncology: Radiation Therapy in a Changing World, will feature reports from the latest clinical trials; panels on global oncology, health disparities and the novel coronavirus; and an immersive attendee experience in a virtual convention center. Media resources are available at www.astro.org/astro2020press.
ASTRO issues first clinical guideline on radiation therapy for cervical cancer
A new clinical guideline from the American Society for Radiation Oncology (ASTRO) provides recommendations for radiation therapy to treat patients with nonmetastatic cervical cancer. The guideline outlines indications and best practices for EBRT and brachytherapy in postoperative and definitive settings, and it also addresses chemotherapy and surgery when used in combination with radiation. The guideline is published online in Practical Radiation Oncology.
ASTRO survey: Fewer patient visits despite enhanced COVID-19 safety measures for radiation oncology clinics
Despite facing challenges such as limited access to PPE during the COVID-19 outbreak, radiation oncology clinics quickly implemented safety enhancements that allowed them to continue caring for cancer patients, according to a new national survey from the American Society for Radiation Oncology (ASTRO). All 222 physician leaders in the survey collected April 16-30 said their practices continued to provide radiation therapy, yet 85% also reported declines in patient visits, and by an average of one-third.
Xenobiotic Receptor Activation, CRISPR/Cas9, Magnetic Resonance-Guided Radiotherapy, and More Featured in May 2020 Toxicological Sciences
During these difficult times, the Society of Toxicology’s official journal, Toxicological Sciences, remains a source for leading research in toxicology, including in the areas of biomarkers, carcinogenesis, and organ-specific toxicology.
The pros and cons of radiotherapy: will it work for you?
Women undergoing radiotherapy for many cancers are more likely than men to be cured, but the side effects are more brutal, according to one of Australia’s most experienced radiation oncology medical physicists.
How Should Radiation Oncologists Manage Prostate Cancer Patients During the COVID-19 Pandemic?
An international team issues recommendations for managing prostate cancer patients during the COVID-19 pandemic
ASTRO issues new clinical guideline on radiation therapy for basal and squamous cell skin cancers
A new clinical guideline from ASTRO provides recommendations on the use of radiation therapy to treat patients diagnosed with the most common types of skin cancers. The guideline details when radiation treatments are appropriate as stand-alone therapy or following surgery for BCC and cSCC, and it suggests dosing and fractionation.
Survey finds 1 in 3 patients needed more information on cancer treatment side effects
One in three adults treated for cancer may experience side effects from treatment they wish they had known more about, according to a new survey published in the Journal of Oncology Practice. The national survey of more than 400 U.S. adults, which was sponsored by the American Society for Radiation Oncology (ASTRO), also found that nine in 10 patients felt they made the right treatment decision despite the desire for more information about treatment side effects.
New research suggests proton radiation therapy can benefit patients with challenging liver tumors
Two new studies support and inform the use of proton radiation therapy to treat patients with hepatocellular carcinoma (HCC), a common but often fatal type of liver cancer for which there are limited treatment options. The studies were published in the International Journal of Radiation Oncology • Biology • Physics, the flagship scientific journal of the American Society for Radiation Oncology (ASTRO).
Taking Baby Aspirin Improves Overall Survival for Patients With Head & Neck, Lung Cancer
In companion presentations at the American Society for Therapeutic Radiation Oncology Annual Meeting, doctors from Roswell Park Comprehensive Cancer Center report new evidence that low-dose aspirin and other anti-inflammatories may improve survival in patients with some head/neck and lung cancers.
Radiation oncology research and clinical trial results to be featured at ASTRO’s Annual Meeting in Chicago
The American Society for Radiation Oncology (ASTRO) announced today the top-rated studies to be highlighted in the press program for the 2019 ASTRO Annual Meeting. Researchers will present their findings in three news briefings being held September 15 through 17 in room W474B of McCormick Place in Chicago and via live webcast.
American Society for Radiation Oncology (ASTRO) to host Annual Meeting in Chicago, September 15-18
10,000+ health professionals expected to attend world’s largest radiation oncology meeting ARLINGTON, Va., June 20, 2019 — The American Society for Radiation Oncology (ASTRO) will host its 61st Annual Meeting at McCormick Place in Chicago, September 15-18, 2019. The meeting…