MD Anderson Research Highlights for December 19, 2022

The University of Texas MD Anderson Cancer Center’s Research Highlights provides a glimpse into recent basic, translational and clinical cancer research from MD Anderson experts. Current advances include a cell cycle checkpoint inhibitor with potential therapeutic effects in an ovarian cancer subtype, a telementoring program for French-speaking oncology providers in Africa, insights into the relationship between obesity and immunotherapy side effects, updates to the world’s largest cancer drug discovery knowledgebase, improvements to treatment response by blocking the EGFR pathway, and a novel noninvasive diagnostic test for immunotherapy-related kidney injury.

Study compares adverse events after two types of bariatric surgery in adolescents

Adolescents who underwent sleeve gastrectomy, a type of weight-loss surgery that involves removing part of the stomach, were less likely to go the emergency room in the five years after their operations than those who had their stomachs divided into pouches through gastric bypass surgery, according to new research.

Hormone therapy could lower risk of immunotherapy-associated myocarditis in women

A new preclinical study from researchers at The University of Texas MD Anderson Cancer Center and the University of California San Francisco (UCSF) has discovered the underlying cause of gender differences in immunotherapy-associated myocarditis after immune checkpoint inhibitor (ICI) treatment. Their findings point to possible treatment strategies for this side effect, which disproportionately affects female patients.

New Research in JNCCN Sheds Light on Multi-Organ Adverse Events from Immunotherapy

New international research in the September 2020 issue of JNCCN—Journal of the National Comprehensive Cancer Network finds immunotherapy-related adverse events (irAEs) can impact more than one organ in a single patient. Multi-organ irAEs are more likely to happen sequentially rather than simultaneously.

Police officers face multifaceted, compounding stressors that can lead to adverse events during high-stress calls

Repeated exposure to high-stress calls for service and ongoing exposure to stress without relief were two of the contributing factors that could lead law enforcement officers to become susceptible to adverse events while performing their duties, according to a new study published in BMC Public Health by researchers at The University of Texas Health Science Center at Houston (UTHealth).