Engineering New Metabolic Pathways that Function Across Microbial Kingdoms

Microbes have enormous potential to produce metabolites with potential industrial applications. To do so, microbes use groups of genes called biosynthetic gene clusters (BGCs) that code for the sets of necessary enzymes. Scientists have computationally predicted the products of hundreds of thousands of BGCs, but have experimentally confirmed fewer than 2,000 of them. Researchers have now developed a computational and experimental strategy to redesign BGCs and determine the natural chemical products they create.

UNLV Study Sheds Light on Ancient Microbial Dark Matter

Omnitrophota are nano-sized bacteria first discovered 25 years ago. Though common in many environments around the world, until now they’ve been poorly understood. An international research team produced the first large-scale analysis of Omnitrophota genomes, uncovering new details about their biology and behavior. The team’s findings are reported in the March 16 issue of the journal Nature Microbiology.

Humans are leaving behind a ‘frozen signature’ of microbes on Mount Everest

In decades past, scientists have been unable to conclusively identify human-associated microbes in samples collected above 26,000 feet. This study marks the first time that next-generation gene sequencing technology has been used to analyze soil from such a high elevation on Mount Everest, enabling researchers to gain new insight into almost everything and anything that’s in them.