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World’s first: Drug guides stem cells to desired location, improving their ability to heal

November 24, 2020 sarah Jonas ALS, Neurodegenative Disease, neurodegenerative brain disorder, Neurological Disorders, Stem Cells

Scientists at Sanford Burnham Prebys Medical Discovery Institute have created a drug that can lure stem cells to damaged tissue and improve treatment efficacy—a scientific first and major advance for the field of regenerative medicine. The discovery, published in the Proceedings of the National Academy of Sciences (PNAS), could improve current stem cell therapies designed to treat such neurological disorders as spinal cord injury, stroke, amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders; and expand their use to new conditions, such as heart disease or arthritis.

Research Results

Cellular pathway of genetic heart disease similar to neurodegenerative disease

November 13, 2020 sarah Jonas ALS, Alzheimer's Disease, Cardiomyopathy, dilated cardiomyopathy, Genetic Research, Mayo Clinic

Research on a genetic heart disease has uncovered a new and unexpected mechanism for heart failure. This landmark discovery found a correlation between the clumping of RNA-binding proteins ― long linked to neurodegenerative disease ― and the aggregates of protein found in the heart tissue of patients with RBM20 dilated cardiomyopathy.

Research Results

ALS Patients Find Hope in New Study Authored by AANEM Members

October 16, 2020 sarah Jonas Aanem, ALS, American Association of Neuromuscular and Electrodiagnostic Medicine, American Neuromuscular Foundation, ANF, Lou Gehrig's Disease

There is some hope on the horizon for patients diagnosed with amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease. More than a dozen members of the American Association of Neuromuscular & Electrodiagnostic Medicine (AANEM) were authors on a study announcing the results showing promise in the fight against ALS that appeared in AANEM’s journal Muscle & Nerve.

Announcement

UB biophysicist to explore molecular mysteries of protein-RNA droplets

September 22, 2020 sarah Jonas ALS, Biophysics, Cellular Biology, Chemistry, Physics, proteins, RNA

Inside human cells, proteins and RNA can cluster together to form spherical droplets that play vital roles in cellular processes as well as in certain human diseases. A $2 million grant will allow biophysicist Priya Banerjee’s team at UB to explore the molecular details of protein-RNA condensates.

Research Results

Brain Cell Death in ALS, Dementia Tied to Loss of Key Biochemical Transport Structure in Nucleus

September 2, 2020 sarah Jonas ALS, Basic Sciences, Brain, Genetics and Genomic Sciences, Johns Hopkins, Mental Health

Researchers have long sought to explain precisely how the most common genetic mutation linked to both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia causes the death of nerve cells.

Research Results

Washington University School of Medicine in St. Louis NEWS RELEASE Embargoed until 5 p.m. ET Wednesday, July 8, 2020 Experimental drug shows early promise against inherited form of ALS, trial indicates

July 8, 2020 sarah Jonas ALS, Amyotrophic Lateral Sclerosis

A clinical trial conducted at Washington University School of Medicine in St. Louis and other sites has found evidence that the experimental drug tofersen lowers levels of a disease-causing protein in people with an inherited form of amyotrophic lateral sclerosis, or ALS, caused by mutations in the gene SOD1.

Feature

URI engineering professor helping ALS patients use their brains to communicate

June 25, 2020 sarah Jonas ALS, Assistive Technology, Biomedical Engineering, Engineering, Lou Gehrig's Disease, neural processing, Neurodegenative Disease, Neuroscience

KINGSTON, R.I. – June 25, 2020 – Doug Sawyer was diagnosed with amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, 11 years ago. His only muscles that still function are those that control eye movement.Despite his disability, Sawyer still works as an engineer from his home, designing electronics for Hayward Industries.

Research Results

Star-Shaped Brain Cells May Play a Critical Role in Glaucoma

June 23, 2020 sarah Jonas ALS, Astrocyte, Glaucoma, Neurodegeneration, Neurodegenerative, NYU Grossman, Nyu Langone, Opthalmalogy

After a brain injury, cells that normally nourish nerves may actually kill them instead, a new study in rodents finds. This “reactive” phenomenon may be the driving factor behind neurodegenerative diseases like glaucoma, a leading cause of blindness.

Research Results

Restoring Nerve-Muscle Communication in ALS

May 28, 2020 sarah Jonas ALS, Neuroscience, Synapse

A new study finds that restoring the protein SV2 in a genetic form of ALS can correct abnormalities in transmission and even prevent cells from dying, providing a new target for future therapies.

Research Results

Researchers Discover Biomarkers of ALS in Teeth

May 21, 2020 sarah Jonas ALS, Biomarker, ENVIRONMENTAL HEALTH, exposomics, Neurology

Mount Sinai scientists have identified biological markers present in childhood that relate to the degenerative and often fatal neurological disease called amyotrophic lateral sclerosis, also known as ALS or Lou Gehrig’s disease, according to a study published in the Annals of Clinical and Translational Neurology in May.

Research Results

Rat Spinal Cords Control Neural Function in Biobots

April 28, 2020 sarah Jonas ALS, APL Bioengineering, biohybrid, Nervous System, Neurology, Rat, Robots, University of Illinois at Urbana-Champaign

Biological robots draw inspiration from natural systems to mimic the motions of organisms, such as swimming or jumping. Improvements to biobots to better replicate complex motor behaviors can lead to exciting biorobotic engineering applications to help solve real world challenges. However, this requires the creation of biohybrid, which is a challenge. Researchers combined an intact rat spinal cord with a tissue-engineered, 3D muscle system. They describe the novel biohybrid system in the journal APL Bioengineering.

Feature

Milestone in Advanced Light Source Upgrade Project Will Bring in a New Ring

January 8, 2020 sarah Jonas 0 Comments Accelerators, Advanced Light Source, ALS, Berkeley, Berkeley Lab, Department Of Energy, DOE, Lawrence Berkeley National Laboratory, LBNL, Light Source, particle accelerators, photon science, Synchrotron, X-rays

An upgrade of the Advanced Light Source, a synchrotron at the U.S. Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab), has passed an important milestone that will help to maintain the ALS’ world-leading capabilities. On Dec. 23 the DOE granted approval for a key funding step that will allow the project to start construction on a new inner electron storage ring known as an accumulator ring.

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