Cellular pathway of genetic heart disease similar to neurodegenerative disease

Research on a genetic heart disease has uncovered a new and unexpected mechanism for heart failure. This landmark discovery found a correlation between the clumping of RNA-binding proteins ― long linked to neurodegenerative disease ― and the aggregates of protein found in the heart tissue of patients with RBM20 dilated cardiomyopathy.

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Mass Eye and Ear Receives $4 Million Gift to Accelerate Research on Genetic Links to Alzheimer’s Disease Resistance

Mass Eye and Ear has received a five-year, $4 Million gift from Good Ventures to spur Dr. Joseph F. Arboleda-Velásquez’s groundbreaking work into Alzheimer’s disease genetic resistance. This transformational gift will enable Dr. Arboleda-Velásquez to build upon the recent discovery of a genetic mutation that protected a woman who had a high familial risk for the condition and amyloid plaque deposits in her brain against early-onset Alzheimer’s.

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