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UrduThe Ohio State University Wexner Medical Center is one of the first nationwide to administer a targeted gene therapy for patients with a specific form of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease that affects the cells in the brain and spine.
Tag: Amytrophic Lateral Sclerosis
RNA modification ‘pivotal’ for protein linked to neurodegeneration in ALS
Scientists know that TDP-43, which helps regulate processing of RNA, may be responsible for the death of nerve cells in ALS and frontotemporal dementia. And a study suggests that a common modification to RNA, a methylation event known as m6A, plays a pivotal role in TDP-43-related neurodegeneration in ALS. Through sequencing analysis, investigators showed that methylation strongly influences the binding of TDP-43 to its RNA targets. They also observed highly abundant RNA methylation in the end-stage tissues of patients with ALS.
Man with ALS makes music with only his eyes
A young man with ALS has continued to pursue his passion for music despite losing his ability to move and speak. He uses a device that track his eye movements to build out songs.