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Urdu[Background] Aryl halides*1) with a benzene ring directly bonded to a halogen atom are readily available and chemically stable, so they are used as a source of benzene rings in organic synthesis. For example, a chemical reaction that generates a…
Tag: PHARMACEUTICAL SCIENCES
Muscles retain positional memory from fetal life
New perspectives on the pathological mechanisms of muscle diseases and regenerative medicine development
Enzyme from fungi shows molecules which way to turn
Xue Sherry Gao and team isolate natural catalysts for better drug synthesis
How an unfolding protein can induce programmed cell death
The death of cells is well regulated. If it occurs too much, it can cause degenerative diseases. Too little, and cells can become tumours. Mitochondria, the power plants of cells, play a role in this programmed cell death. Scientists from…
Do heart medications affect COVID-19 outcomes?
Cardiovascular drugs do not affect COVID-19 outcomes–such as disease severity, hospitalizations, or deaths–according to an analysis of all relevant studies published as of November 2020. The findings are published in the British Journal of Clinical Pharmacology . Investigators included 429…
Closer to cure: New imaging method tracks cancer treatment efficacy in preclinical studies
New non-invasive method to track the progress of one highly sought-after anti-cancer immunotherapy can change research in the field
Bowel cancer data reinforce need to reduce unnecessary antibiotic use
ESMO World Congress on Gastrointestinal Cancer 2021
Poorer survival in obese colorectal cancer patients possibly linked to lower chemotherapy doses
ESMO World Congress on Gastrointestinal Cancer 2021
Researchers reduce severity of sleep apnoea by at least 30 per cent
New research published in The Journal of Physiology shows that researchers have successfully repurposed two existing medications to reduce the severity of sleep apnoea in people by at least 30 per cent. Affecting around 1.5 million adults in the UK,…
Hi-tech lab to boost COVID-19 diagnostic capability, prepare for future pandemics
Singapore, 1 July 2021 – Nanyang Technological University, Singapore (NTU Singapore) and Pathnova Laboratories, a medical diagnostic company backed by Temasek Life Sciences Accelerator and headquartered in Temasek Life Sciences Laboratory, is contributing to Singapore’s COVID-19 diagnostic capability through its…
Prenatal exposure to THC, CBD affects offspring’s responsiveness to fluoxetine
BLOOMINGTON, Ind. — Scientists at Indiana University have found that significant amounts of the two main components of cannabis, THC and CBD, enter the embryonic brain of mice in utero and impair the mice’s ability as adults to respond to…
Mefloquine: A promising drug ‘soldier’ in the battle against COVID-19
Scientists propose the repurposing of anti-malarial drug mefloquine to fight the novel coronavirus
From meadow to plate: The cultured meat that replaces animals with grass
An affordable lab system that uses grass blades to turn cells into cultured meat has been developed at the University of Bath in the UK
Computational analyses reveal 200 drugs that could be repurposed to treat COVID-19
Identification of SARS-CoV-2-induced pathways reveals drug repurposing strategies
Small biotechs team up with big partners to manufacture drugs
Many of the most promising new molecules to treat diseases come from smaller biotechnology firms, which often lack resources to scale up production when it’s time for their drugs to go to large-scale clinical trials or the market. Now, a…
Reactive oxygen species (ROS): Key components in cancer therapies
The article by Dr. Biswa Mohan Sahoo et al. is published in Anti-Cancer Agents in Medicinal Chemistry, 2021
Acta Pharmaceutica Sinica B Volume 11, Issue 6 publishes
Special issue: Celebrating 10 years of Acta Pharmaceutica Sinica B (APSB)
Clinical and pre-clinical antimicrobial drug development
This book series brings updated reviews to readers interested in advances in the development of anti-infective drug design and discovery. It covers a range of topics including rational drug design and drug discovery, medicinal chemistry, in-silico drug design, combinatorial chemistry,…
Nanomaterials: Evolution and Advancement Towards Therapeutic Drug Delivery
‘Nanomaterials: Evolution and Advancement Towards Therapeutic Drug Delivery’ gives the present status and future perspective of Polymeric nanoparticles, Liposomes, Carbon Nanotubes, Magnetic Nanoparticles, Silica Based nanomaterial, Hydrogels, Metallic Nanoparticles, Cyclodextrins, Poly (Lactide-Co-Glycolide) and its Copolymers. Improvement of a vector for…
Had COVID-19? One vaccine dose enough; boosters for all, study says
Two mRNA vaccines against COVID-19 have proven safe and effective in clinical trials, as well as in the millions of people who have been vaccinated so far. But how prior SARS-CoV-2 infection affects vaccine response, and how long that response…
Seeking a treatment for IBS pain in tarantula venom
For patients who have inflammatory bowel syndrome (IBS), the condition is literally a pain in the gut. Chronic — or long-term — abdominal pain is common, and there are currently no effective treatment options for this debilitating symptom. In a…
Four-component, and asymmetric radical 1,4-oxy-trifluoromethylation to olefins
Vanadium oxo (VO) species were often used to oxidise sulfide/amine compounds and alkenes when combined with peroxide oxidants. VO species are well known as important vitamin supplements for potential diabetic prevention. They are highly prevalent as metalloenzyme like haloperoxidase. The…
Statin therapy not associated with cognitive decline, dementia in older adults, study says
Observational study adds to growing evidence on statins, but randomized trials are still needed
Passing the COVID test in just five minutes
Researchers at Osaka University develop a new highly sensitive test for the SARS-CoV-2 virus that utilizes a fusion of artificial intelligence and nanopore technology which may enable rapid point-of-care testing for COVID
Sensitive and specific detecting biomarker of radiation-resistant nasopharyngeal carcinoma
In a paper published in NANO , a team of researchers from Jiangnan University, China have prepared a convenient sensing platform which can detect microRNA-205 (MiR-205) with high sensitivity and excellent selectivity using TpTta-COF nanosheet and fluorescent oligonucleotide probes. Nasopharyngeal…
FDA advisory panelist outlines issues with aducanumab’s approval for Alzheimer’s disease
Below please find a summary for a new article that will be published today in Annals of Internal Medicine . The summary is not intended to substitute for the full article as a source of information. This information is under…
Reduced-dose gadobutrol vs standard-dose gadoterate for contrast-enhanced brain MRI
A 25% reduced gadobutrol dose demonstrated non-inferior efficacy versus 100%-standard dose of gadoterate for contrast-enhanced brain MRI, particularly in patients undergoing multiple contrast-enhanced examinations
Algorithm uses mass spectrometry data to predict identity of molecules
New method saves time, money in developing new drugs
Genetically engineered nanoparticle delivers dexamethasone directly to inflamed lungs
Nanoengineers at the University of California San Diego have developed immune cell-mimicking nanoparticles that target inflammation in the lungs and deliver drugs directly where they’re needed. As a proof of concept, the researchers filled the nanoparticles with the drug dexamethasone…
Measuring the elimination of plastic particles from the body in mice
Postdoctoral Researcher Outi Keinänen from the University of Helsinki developed a method to radiolabel plastic particles in order to observe their biodistribution on the basis of radioactivity with the help of positron emission tomography (PET). As a radiochemist, Keinänen has…
Scientists prepare for next coronavirus pandemic, maybe in 2028?
New drug target found for future and current coronaviruses
Compounds derived from hops show promise as treatment for common liver disease
CORVALLIS, Ore. – Research by Oregon State University suggests a pair of compounds originating from hops can help thwart a dangerous buildup of fat in the liver known as hepatic steatosis. The findings, published today in eLife , are important…
Antidepressant pollution alters crayfish behavior, with impacts to stream ecosystems
Increased foraging and reduced aggression have the potential to alter stream functioning
Alzheimer disease research results over-hyped if science papers omit mice from the title
Scientists call for accurate reporting of animal studies to avoid misleading the public with exaggerated news headlines
Medication may help heavy-drinking smokers improve their health
UCLA study provides evidence that varenicline can aid them in quitting smoking, reducing drinking
Ibuprofen and other NSAIDs superior to codeine for managing outpatient postoperative pain
Nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen provide better pain control and have fewer adverse effects than codeine, a commonly prescribed opioid, when prescribed after outpatient surgery, according to new research published in CMAJ (Canadian Medical Association Journal) https:/ /…
Postop chylothorax treated with intranodal lymphangiography, ethiodized oil
High-dose intranodal lymphangiography with ethiodized oil is a safe and effective procedure for treating high-output postsurgical chylothorax with chest tube removal in 83% of patients
COVID-19 creates conditions for emergence of ‘superfungus’ in Brazil
Fully occupied intensive care units (ICUs). Physically and mentally exhausted health workers. Chaotically overcrowded hospitals. These and similar problems posed by the COVID-19 pandemic in Brazil have created ideal conditions for the emergence of Candida auris , a microorganism some…
Easy, inexpensive, efficient: Researchers improve efficacy of new malaria drug
Artemisone is a promising substance in the fight against malaria. However, the active ingredient has yet to be used due its instability and because it is not easily absorbed by the body. A team from Martin Luther University Halle-Wittenberg (MLU)…
Women leaving jail have high vaccine hesitancy; app drops resistance, boosts literacy
Vulnerable population offers keys to better communications on vaccines, researchers argue
CWRU researcher secures $1.2M to develop MS diagnostic tests
CLEVELAND–Case Western Reserve University researcher Farren Briggs was awarded $1.2 million over three years from the National Institute of Neurological Disorders and Stroke (NINDS) at the National Institutes of Health to identify biomarkers to improve the diagnoses of multiple sclerosis…
Many surgery patients get opioid prescriptions, but many don’t need to, study suggests
Effective pain control with equal short-term outcomes and patient satisfaction seen in patients who got non-opioid pain medication
Could neutrophils be the secret to cancer’s Achilles’ heel?
A study published in the June 10, 2021 issue of Cell describes a remarkable new mechanism by which the body’s own immune system can eliminate cancer cells without damaging host cells. The findings have the potential to develop first-in-class medicines…
A new culprit in antibacterial resistance: cysteine persulfide
A joint research project based in Kumamoto University , Japan has developed a new, highly sensitive analytical method that can detect degraded β-lactam antibacterial agents used in the treatment of bacterial infections. With this method, researchers found that reactive sulfur…
New adaptable nanoparticle platform enables enhanced delivery of gene therapies
Scientists have developed polypeptide-based materials that act as effective vectors for delivering gene therapies. The first-of-its-kind platform enables the vectors to be adapted to suit the specific gene therapy cargo. The work, led by researchers from RCSI University of Medicine…
DNA methylation changes and characteristics in neurons of bipolar disorder patients
A research collaboration based in Kumamoto University , Japan has revealed the DNA methylation status of gene transcriptional regulatory regions in the frontal lobes of patients with bipolar disorder (BD). The regions with altered DNA methylation status were significantly enriched…
How COVID-19 wreaks havoc on human lungs
New structure shows how virus envelope protein hijacks cell-junction protein and promotes viral spread; findings could speed the design of drugs to block severe effects of COVID-19
A drug from resin to combat epileptic seizures
New molecules, developed by researchers at Linköping University, have promising properties as possible drugs against epilepsy. A study published in the journal Epilepsia shows that several of the molecules have antiseizure effects. In people with epilepsy, the nerve cells in…
Motor neurons derived from patients point to new possible drug target for ALS
Study debuts a high-throughput human screening platform to assess neuron hyperexcitability, a cardinal feature of this neurodegenerative disorder
Cell Reports publishes data supporting the importance of ion channel, Kv7.2/7.3 as a target in ALS
Data supports QurAlis’ approach to treat hyperexcitability induced neurodegeneration in ALS patients; QurAlis gears up for clinical development of therapeutic candidate, QRL-101