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UrduScientists from St. Jude Children’s Research Hospital, Seattle Children’s and the Children’s Oncology Group (COG) have identified novel genetic variations that influence relapse risk in children with standard risk B-cell acute lymphoblastic leukemia (SR B-ALL), the most common childhood cancer.
Tag: Relapse
Restricting flavoured vapes could harm smoking cessation efforts, finds study
Restricting the choice of flavoured vapes, also known as e-cigarettes, could have an adverse effect on the many adults who use them to reduce or quit smoking, according to a new University of Bristol-led study published in the journal Harm Reduction.
Novel bispecific design improves CAR T–cell immunotherapy for childhood leukemia
Findings from St. Jude Children’s Research Hospital showed a novel dual targeting approach, where a single molecule can recognize two potential cancer-related proteins, is more effective than the single targeting approach, preventing immune escape.
Palex and Inbiomotion introduce pioneering test to aid oncologists in predicting recurrence and survival rates in breast cancer patients
Spain is the first country in the world to have this technology
• Results showing the clinical utility of the test were published in
Lancet Oncology and the Journal of National Cancer Institute
• The test is now available to oncologists and pathologists and will
benefit an estimated 24,000 patients each year in Spain
People with Severe Alcohol Use Disorder Have Impaired Ability to Learn From Others’ Painful Experiences, Raising Their Risk for Ongoing Dangerous Drinking, Study Suggests
People with alcohol use disorder (AUD) are less able to learn from others’ negative experiences, potentially rendering them more vulnerable to maintaining their dangerous drinking or relapsing, according to the first study of its type. The study explored social cognition, processes that enable us to understand and interact with others, and specifically social learning, our ability to learn by observing others’ experiences.
Racial discrimination contributes to increases in alcohol craving to cope with racial stress
Alcohol craving is associated with relapse following alcohol use disorder (AUD) treatment. A new study is the first to examine how distinct experiences of interpersonal racial discrimination contribute to elevated alcohol craving. Findings will be shared at the 46th annual scientific meeting of the Research Society on Alcohol (RSA) in Bellevue, Washington.
New UCI study reveals brain circuit responsible for cocaine withdrawal-induced anxiety and relapse-related behavior
New research from the University of California, Irvine, finds that drug withdrawal-induced anxiety and reinstatement of drug seeking behaviors are controlled by a single pathway in the brain and centered around dopamine cells.
Comprehensive clinical sequencing opens door to the promise of precision medicine
St. Jude Children’s Research Hospital study highlights the power of comprehensive whole genome, whole exome and RNA sequencing to better understand and treat each patient’s cancer.
Chemotherapy can induce mutations that lead to pediatric leukemia relapse
A collaboration led by St. Jude Children’s Research Hospital, Shanghai Children’s Medical Center and others revealed how thiopurines produce mutations that lead to multi-drug resistant leukemia and relapse.
New Diagnostic Method May Predict Relapse Risk for Those Recovering from Prescription Opioid Addiction
Rutgers scientists have used a diagnostic technique for the first time in the opioid addiction field that they believe has the potential to determine which opioid-addicted patients are more likely to relapse.
From the clinic to the lab, understanding medulloblastoma relies on molecular profiling
A pair of research papers from St. Jude Children’s Research Hospital report on a medulloblastoma clinical trial that provides insights to guide treatment and shed light on relapsed disease.
Inherited genetic variant influences response to leukemia treatment for some children
St. Jude researchers showed that an inherited variant of the GATA3 gene is tied to minimal residual disease levels and response to therapy for acute lymphoblastic leukemia.
Study reveals properties of cells fated to relapse in acute lymphoblastic leukemia
Researchers have found that genetically defined subpopulations of leukemia cells present at diagnosis have distinct characteristics that lead to relapse.
A Person’s Perception of Risk Can Tell Us About Their Chances of Opioid Relapse
People in treatment for opioid addiction are more likely to relapse when they become more tolerant of risks, according to a study by Rutgers and other institutions. The findings can help clinicians better predict which patients are most vulnerable.