Lower prostate cancer screening rates associated with subsequent increase in advanced cancers

In the face of conflicting evidence over the risks and benefits of routine prostate cancer screenings, a large, longitudinal analysis found Veterans Health Administration (VA) medical centers with lower prostate screening rates had higher rates of metastatic prostate cancer cases in subsequent years than centers with higher screening rates.

Researchers find favorable tradeoffs of PSA screening for prostate cancer

University Hospitals’ Jonathan Shoag, MD, and a team of researchers from Case Western Reserve University and the Case Comprehensive Cancer Center, Weill Cornell Medical Center, the Fred Hutchinson Cancer Research Center, and others, set out to assess the tradeoffs of PSA screening using long-term epidemiologic data. “No matter the assumptions,” Shoag said, “the data showed lower numbers than prior estimates, many in the low single digits, for the number needed to treat to prevent a prostate-cancer death. This result was observed in all men, and especially for Black men.” The researchers presented their findings in a late-breaking abstract at the American Urological Association’s annual meeting this month and the study was published May 15 in The New England Journal of Medicine Evidence.

New Study Examines Long-Term Benefits of Prostate-Specific Antigen (PSA) Screening for Prostate Cancer

Genitourinary cancer specialists from Seattle Cancer Care Alliance, University of Washington School of Medicine, Fred Hutchinson Cancer Research Center, and Weill Cornell Medicine have published an article , “Reconsidering the Trade-offs of Prostate Cancer Screening,” in the New England Journal of Medicine on the long-term benefits of prostate-specific antigen (PSA) screening for prostate cancer in men. In the article, investigators concluded that the advantages of widespread screening – including reduced mortality and the potential to avoid metastases – are likely greater than estimates cited in current guidelines.