When they find themselves trapped in an amyloid-ridden mouse brain, transplanted human neurons meet an untimely, necrotic demise. While this had been known before, a new-and-improved xenograft model has unveiled some of the dirty details behind this cascade.
Because amyloidosis doesn’t affect a specific organ and can be present throughout the body including the heart, kidneys, liver and brain, unraveling the underlying cause of amyloid fibril creation – a hallmark of this disease – is complex and challenging. A monumental $11.5 million gift from philanthropists Ann and John Wood will enable FAU’s Schmidt College of Medicine to create a game-changing infrastructure using a whole-body approach and multi-disciplinary team.
Physician-scientists from Cedars-Sinai Cancer will present research and are available for comment on breaking news throughout the American Society of Hematology Annual Meeting & Exposition taking place Dec. 10-13 in New Orleans.