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New research published ahead of print in the journal Function finds that traumatic brain injury (TBI) disrupts inward-rectifier potassium channel

Research Results

Eggs Reveal What May Happen to Brain on Impact

January 19, 2021 sarah Jonas Biophysics, Brain, Brain Injury, Concussion, Physics, PHYSICS OF FLUIDS

Our brains consist of soft matter bathed in watery cerebrospinal fluid inside a hard skull, and in Physics of Fluids, researchers describe studying another system with the same features, an egg, to search for answers about concussions. Considering that in most concussive brain injuries, the skull does not break, they wanted to find out if it was possible to break or deform the egg yolk without breaking the eggshell and did a simple experiment using an egg scrambler, measuring the soft matter deformation.

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A Mother’s Fight for Her Son After Brain Injury

January 13, 2021 sarah Jonas Brain Activity and Disease, Brain Injury, Brain Surgery, Mother Son Relationship

Peter Davey was admitted to the hospital after a hypoxic brain injury. Neurosurgeons including Dr. Gaurav Gupta at Rutgers Robert Wood Johnson Medical School did not think Peter would survive, and even after performing life-saving surgery, it was not clear that he would be able to regain the ability to walk, talk, read or write. A year later, Peter has regained all his mental and physical abilities. Dr. Gupta attributes this outcome not only to Peter’s determination and stamina, but also the resilience of his mother.

Research Alert

Hospital Environmental Effects on Sleep in Adults With Traumatic Brain Injury in Rehabilitation

November 13, 2020 sarah Jonas Brain Injury, Nursing, Patient Care, Sleep

Abstract Purpose The aim of this study was to describe sleep patterns of adults with traumatic brain injury and examine

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Using Machine Learning to Predict Pediatric Brain Injury

October 1, 2020 sarah Jonas Brain Injury, ECMO, Pediatrics

DALLAS – Oct. 1, 2020 – When newborn babies or children with heart or lung distress are struggling to survive, doctors often turn to a form of life support that uses artificial lungs. This treatment, called Extracorporeal Membrane Oxygenation (ECMO), has been credited with saving countless lives. But in some cases, it can also lead to long-term brain injury.

Research Results

Acid reflux drug could help newborn babies recover from brain injury, study suggests

September 29, 2020 sarah Jonas Brain Injury, neonatal care, Neurology

Researchers in China have discovered a potential way to prevent a lack of oxygen or blood flow from causing long-lasting brain damage in newborn children. The study, which will be published September 29 in the Journal of Experimental Medicine (JEM), suggests that targeting the histamine H2 receptor with drugs already used to treat acid reflux in infants could help newborns recover from hypoxic-ischemic encephalopathy (HIE), a condition that affects over 1 in 1,000 live births and can cause life-long neurological disabilities.

Research Results

Concussion discovery reveals dire, unknown effects of even mild brain injury

September 10, 2020 sarah Jonas Aging, Alzheimer's Disease, Athletes, BIG Center, Brain, Brain Injury, Center for Brain Immunology and Glia, Concussions, Dementia, Football, John Lukens, Military, National Football League, Neurodegenerative Disease, Neuroimmunology, Neurological Disease, Neuroscience, NFL, Soccer, Sports, TBI, Traumatic Brain Injury, University Of Virginia, University of Virginia School of Medicine, UVA, UVA School of Medicine

Even mild concussions cause severe and long-lasting impairments in the brain’s ability to clean itself, and this may seed it for Alzheimer’s, dementia and other neurodegenerative problems.

Research Results

Glasgow Coma Scale: A Simple Tool to Use When Verbal Component Scores Are Missing

September 8, 2020 sarah Jonas Brain Injury, Head Injury

The authors have created a simple and practical tool for use in assessing impaired consciousness in the clinical setting when the verbal component of the Glasgow Coma Scale is missing.

Research Results

Simple Blood Test May Predict Concussion Severity Just as Well as Spinal Tap

July 8, 2020 sarah Jonas Brain Injury, Concussion, neurofilament light protein

A blood biomarker in people who have had concussions may be just as accurate at predicting the severity of the injury and how long it will last as biomarkers that are obtained through more expensive and invasive tests, according to a study published in the July 8, 2020, online issue of Neurology®, the medical journal of the American Academy of Neurology.

Research Results

Scientists show MRI predicts the efficacy of a stem cell therapy for brain injury

May 12, 2020 sarah Jonas Brain Injury, Cerebral Palsy, MRI, Neural Stem Cells, Parkinson's Disease, perinatal hypoxic-ischemic brain injury, Regenerative Medicine, Spinal Cord Injury, Stem Cells

Scientists at Sanford Burnham Prebys Medical Discovery Institute and Loma Linda University Health have demonstrated the promise of applying magnetic resonance imaging (MRI) to predict the efficacy of using human neural stem cells to treat a brain injury—a first-ever “biomarker” for regenerative medicine that could help personalize stem cell treatments for neurological disorders and improve efficacy. The study was published in Cell Reports.

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PECASE Honoree Elizabeth Nance Highlights the Importance of Collaboration in Nanotechnology

February 27, 2020 sarah Jonas Blood Brain Barrier, Brain Injury, Drug Delivery, Nanoparticles

Nanoparticles have been used to treat disease for decades, but scientists are now learning more about how they move through human tissue. PECASE honoree and NIGMS grantee Elizabeth Nance is enlisting minds across different scientific fields to solve the challenge of using nanoparticles to target the right site within the body to increase the effectiveness of treatments for newborn brain injury.

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