Tag: CARCINOGENS

Showing a clear clinical benefit for patients, irrespective of RAS mutational status, primitive tumor side and metastases surgery

There is convincing evidence that excess body weight is associated with increased risk for late onset (> 50 years of age) colorectal cancer (CRC)

The aim of this @Oncotarget study is to determine whether tumor cells isolated from ascites of EOC patients can be used to determine chemotherapy sensitivity by using in vitro proliferation assays

“In conclusion, estrogen receptor α PvuII polymorphism is associated with dementia in a Brazilian cohort”

The @Oncotarget authors aimed to assess the effect of cirrhosis on outcomes in iCCA patients

“Suggesting that combined targeting of SLC6A14 and AMPK can be exploited as a therapeutic approach to starve tumor cells”

“Elevated PLT count seems to identify a subgroup of patients with poor outcome in the IMDC intermediate-risk population with ccRCC”

“The @Oncotarget authors demonstrate that MEK inhibitors are a promising targeted therapy for the basal subtype of bladder cancer, and their data indicate that drug screening of 3D cultures provides an important resource for hypothesis generation”

The @Oncotarget authors show a drug class-effect with MEKi to stimulate NK cells, inhibit inflammatory cytokines and block host-factors for SARS-CoV-2 infection leading also to suppression of SARS-CoV-2-S pseudovirus infection of human cells

“These data support further investigation of PI3K inhibition in HNSCC and suggests gene expression patterns associated with PI3K signaling”

‘The established mouse cachexia model can therefore be considered useful for analyzing cancer-derived myocardial damage’

‘The results of the use of melatonin drugs in palliative treatment of patients with end-stage prostate cancer are shown’

“The Oncotarget author’s findings show that MRI is reliable for T staging of cervical NEC”

“Simvastatin efficiently controlled OCCC proliferation and migration, thus showing potential as a candidate drug for the treatment of OCCC.”

The objective of this Oncotarget study was to elucidate the molecular mechanism of actions of 2MeOE2, a known microtubule disrupting agent, in inducing apoptosis in ovarian tumors

The Oncotarget findings suggest that MEKi induced an increased expression of tumor-associated antigens, which in combination with anti-tumor antibodies, generated a robust adaptive anti-tumor response that was sustained by immune checkpoint inhibition the

Reduced expression of TBX15 in tumor tissue represents a potential biomarker for predicting poor survival of patients with HCC

The Oncotarget author’s hypothesis is that ADC values will inversely correlate with Ki-67 expression and that tumors with higher ADC values above the median will have improved OS and PFS

Dr. Margot Bucau from The Hôpital Bichat-Claude Bernard said, ‘Anal intraepithelial neoplasia (AIN) is the precursor lesion for anal squamous cell carcinomas (ASCC)’

“Here the Oncotarget authors describe the results of preclinical studies with an anti-mouse CD45 antibody 30F11”

The Oncotarget authors propose that methylation of DVDMR represents a novel epigenetic biomarker that determines the levels of IGF2 protein expression in breast cancer.

Oncotarget recently published ‘Heterogeneity of CEACAM5 in breast cancer’ which reported that Here, we examined a repository of 110 cryopreserved primary breast carcinomas by immunohistochemistry to assess the distribution of CEACAM5 in tumor subtypes