New study reveals that some children with common form of eczema should also be tested for allergic reactions

Eczema, which is a group of medical conditions that causes inflamed, irritated, and often itchy skin, affects millions of people worldwide. A new article published in the reveals that children diagnosed with a type of eczema called atopic dermatitis — which they usually develop by 5 years of age — may also need to be tested for a second type of eczema called allergic contact dermatitis, which has similar symptoms and can be triggered by a range of substances that cause an allergic reaction.

CHOP Researchers Validate Pediatric “Allergic March” in Largest National Study of its Kind

In the largest study of its kind, researchers from Children’s Hospital of Philadelphia (CHOP) used electronic health record (EHR) data from more than 200,000 pediatric patients to describe patterns of pediatric allergies across the United States, validating a population-level pattern of allergy development known as the “allergic march,” in which allergies first present as eczema, followed by food allergies, asthma, and environmental allergies. The researchers also found that a rare food allergy called eosinophilic esophagitis (EoE), which has historically been considered a disease affecting primarily White males, is more common among non-White patients than previously reported.

Mount Sinai Researchers Awarded $12 Million NIH Grant to Create a Center to Unravel Novel Causes of Food Allergy and Atopic Dermatitis

Mount Sinai researchers have been awarded $12 million over five years by the National Institutes of Health to create a center to elucidate novel causes of, and contributing factors to, food allergies and atopic dermatitis. The Systems Biology of Early Atopy (SunBEAm) Analysis and Bioinformatics Center intends to develop a better understanding of allergy development. The center will apply systems biology to identify early-life markers of risk for food allergies and atopic dermatitis (also known as eczema), as well as biological pathways underlying these common conditions, through the profiling and analysis of longitudinal multi-omics data from a multi-center pre-birth cohort of 2,500 children.

How to tell the difference between dry hands and hand eczema

Hand eczema is one of the most common forms of eczema, causing dry, itchy, and irritated skin affecting the whole hand, including the fingers. This skin condition can negatively impact a person’s quality of life because we use our hands often. In recognition of Eczema Awareness Month in October, board-certified dermatologists share information about the causes of hand eczema and how it can be treated to keep the condition from worsening.

The right moisturiser for children with eczema is the one that they like to use, study finds

The Best Emollients for Eczema trial has found that no one type of moisturiser is better than another. This study, the first in the world to directly compare different types of moisturisers, highlights the importance of patient education and choice when deciding which moisturisers to use for children with eczema. The results from the National Institute for Health and Care Research (NIHR) funded study are published in The Lancet Child and Adolescent Health and British Journal of General Practice today (24 May).

Research News Tip Sheet: Story Ideas from Johns Hopkins Medicine

During the COVID-19 pandemic, Johns Hopkins Medicine Media Relations is focused on disseminating current, accurate and useful information to the public via the media. As part of that effort, we are distributing our “COVID-19 Tip Sheet: Story Ideas from Johns Hopkins” every other Wednesday.

Acute itching in eczema patients linked to environmental allergens

New research from Washington University School of Medicine in St. Louis indicates that allergens in the environment often are to blame for episodes of acute itch in eczema patients, and that the itching often doesn’t respond to antihistamines because the itch signals are being carried to the brain along a previously unrecognized pathway that current drugs don’t target.

Study finds antibiotics before age 2 associated with childhood health issues

In a retrospective case study, Mayo Clinic researchers have found that antibiotics administered to children younger than 2 are associated with several ongoing illnesses or conditions, ranging from allergies to obesity. The findings appear in Mayo Clinic Proceedings.

Mount Sinai Researcher Identifies Single Gene Biomarker to Differentiate Between Atopic Dermatitis and Psoriasis Using Adhesive Tape Strips

Mount Sinai researchers have pinpointed a single gene biomarker, nitride oxide synthase 2 (NOS2) that can distinguish atopic dermatitis (AD) and psoriasis with 100 percent accuracy using adhesive tape strips, a non-invasive alternative to skin biopsy. The research will be published online today in the Journal of Allergy and Clinical Immunology.

Mount Sinai Researcher Receives NIH Award to Study Immune Responses of Patients With Inflammatory Skin Diseases in the Setting of COVID-19 Infection

The study will aim to understand whether systemic medications and biologics, such as dupilumab—a monoclonal antibody that binds to an inflammatory molecule, IL-4 receptor alfa, and inhibits the inflammatory response that leads to rashes and itching from atopic dermatitis/eczema—may have a positive or negative impact on COVID-19 responses in patients who have the disease.

Painless Tape Strips Used to Detect Molecular Changes in Skin of Children with Eczema

In a study using non-invasive tape strips in young children with eczema (or atopic dermatitis), researchers found many molecular signs of immune dysfunction and skin changes that relate to disease activity. These signs (or biomarkers) were present even before eczema was visible and can be used to track disease activity over time. With more research, these biomarkers also may help predict response to medicine and development of conditions associated with eczema, such as asthma, other allergies, infections and even attention deficit hyperactivity disorder (ADHD). Findings were published in JAMA Dermatology.