In APL Bioengineering, researchers examine the local communication between endothelial cells and tumors cells and its effects on endothelial cell orientation. The approach uses co-cultured human umbilical vein endothelial cells and breast epithelial tumor cell lines to simulate the tumor-endothelial interaction. The group found the clockwise chirality of the hUVECs was less affected by local hormone signaling and more so by direct physical contact with tumor cells. Specific proteins on the tumor cell binding to others on endothelial cells appeared to play a role in changing the clockwise chirality of hUVECs.
Tag: Tumor Cells

Cell competition may explain cancer relapses, UT Southwestern research suggests
A normal process called cell competition, in which healthy tissues eliminate unhealthy cells, could be responsible for cancer relapses in patients months or years after they were declared cancer-free
Study reports blocking key enzyme boosts anti-cancer T-cell responses and resistance to immunosuppression
A study led by LSU Health New Orleans cancer researchers describes a novel therapeutic strategy to overcome tumor-induced immunosuppression.
Scientists proposed a carrier for targeted chemotherapy drug
Researchers at Ural Federal University (UrFU) have proposed the use of polyoxometallate nanoclusters as a carrier for chemotherapy drug.
New pathway for DNA transfer discovered in tumor microenvironment
University of Notre Dame researchers have discovered another way tumor cells transfer genetic material to other cells in their microenvironment, causing cancer to spread.
A more sensitive way to detect circulating tumor cells
Researchers reporting in ACS Sensors have developed a method that could more sensitively detect circulating tumor cells within the complex environment of blood.