Chemotherapy can induce a painful peripheral neuropathy (CIPN), a chronic condition and common adverse effect for cancer patients undergoing treatment. Researchers at University of California San Diego School of Medicine, with colleagues elsewhere, have used a mouse model to demonstrate the pivotal role of cholesterol in CIPN, and proposed a novel therapeutic approach to reverse it.
Single-cell analysis, done in three colon cancer cell lines, is believed to be the first to profile transcriptome-level changes in response to DNA damage across individual cells.
Chemotherapy usually cures children diagnosed with acute lymphoblastic leukemia (ALL), but the treatment may hamper brain development and impact key cognitive functions including sensory processing, memory, and attention. Researchers at Albert Einstein College of Medicine, Children’s Hospital at Montefiore (CHAM), and Rutgers Cancer Institute of New Jersey have received a five-year, $4.6 million grant from the National Institutes of Health (NIH) to determine how chemotherapy exerts its damaging effects on the brain. Their long-term objective is to use this information to develop protective interventions that can prevent permanent harm.
The cardioprotective drug dexrazoxane preserved cardiac function in pediatric patients undergoing chemotherapy for acute myeloid leukemia (AML) without compromising overall patient survival and potentially improving it, according to a new study by researchers at Children’s Hospital of Philadelphia (CHOP). The results suggest dexrazoxane should be considered for cardioprotection in all pediatric patients undergoing standard chemotherapy for AML.
An analysis of more than 10,000 gliomas and clinical outcomes reported in Nature by scientists in Boston and Paris found that glioma patients whose tumors were hypermutated actually had no significant benefit when treated with checkpoint blockers.
A study led by The University of Texas MD Anderson Cancer Center has found that myelin is surprisingly dynamic, a discovery that has implications for treatment of multiple sclerosis and a type of myelin damage caused by some chemotherapy drugs, often referred to as “chemobrain.”
A Baylor University interior design team is assisting Decon7 Systems — manufacturer of a powerful disinfectant used by the military, first responders and, most recently, hospitals in China as they battle Coronavirus Disease (COVID-19) 19 — in designing a hyperclean play space for children with diseases that compromise their immunity.
If you’re looking for health and fitness story ideas, view these research highlights from Exercise and Sport Sciences Reviews and Medicine & Science in Sports & Exercise®, ACSM’s flagship research journal.
A metabolic inhibitor was able to kill human cancer cells of the skin, breast, lung, cervix and soft tissues through a non-apoptotic route — catastrophic macropinocytosis. The inhibitor acted synergistically with the chemotherapy drug, cyclophosphamide, in mouse xenografts to reduce tumor growth.
Made with extracellular matrix (ECM) from pig brains and seeded with tumors from patients, the system is revealing tumor/ECM interactions that aid tumor growth, providing potential targets for new therapies.