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Tag: LIVER
Dietary supplement may help in the treatment of fatty liver
A recent study by researchers at the University of Jyväskylä was successful in partially preventing fatty liver disease in rats.
Vitamin E from palm oil useful in boosting immune response based on studies on liver cells
The article by Dr. Ahmed Atia and colleagues is published in Current Pharmaceutical Biotechnology, 2020
SARS-CoV-2 might attack red marrow and block new erythrocytes formation
Specialists from the Department of Fundamental Medicine of Far Eastern Federal University (FEFU) with Russian and Japanese colleagues have probed into mechanisms of COVID-19 inside-the-body distribution linked to erythrocytes damaging. According to researchers, the virus might attack red marrow, thus…
Eating less suppresses liver cancer due to fatty liver
Liver cancer from too much fat accumulation in the liver has been increasing in many countries including Japan. In order to change this unfortunate state of affairs, it is important to improve the prognosis of non-alcoholic fatty liver disease. Most…
Surprising players in acute liver failure point to potential treatment
Gut microbes and host cells jointly contribute to the progression of this mostly incurable disease
A new paradigm in patient care
Mechanical engineering assistant professor Elliot Hawkes is one of 20 Packard Fellows for 2020
Ontario should vaccinate newborns for hepatitis B, study suggests
Not all pregnant women are universally screened for hepatitis B virus (HBV) in Ontario, even though this screening is recommended, and the majority of those who test positive do not receive follow-up testing or interventions, leading to infections of newborns,…
Liver cancer diagnoses and deaths impacted by geography and household income
An analysis of information from a large U.S. cancer database indicates that patients with liver cancer from rural regions and lower income households often have more advanced cancer at the time of diagnosis and face a higher risk of death…
The road to uncovering a novel mechanism for disposing of misfolded proteins
About 30 years ago, Dr. Richard Sifers set out on a journey to discover why people with a rare condition known as alpha1-antitrypsin (AAT) deficiency present with high variation in the severity of liver disease. His journey led him to…
Immune activation in the liver illuminated with new glycan-tagging strategy
A new chemistry technique expands known targets of signaling protein galectin-3, with implications for liver disease and the immune system
Body MRI reinterpretations plagued by discrepancies and errors
Secondary interpretations of body MR images at tertiary care centers identify high rate of discrepancies, with cognitive error types predominating, suggesting subspecialty interpretations and additional resources are needed
Start-up awarded grant to develop contrast agent for early detection of liver disease
A start-up led by chemistry professor Jenny Yang has received a grant to accelerate development of MRI contrast agents that allow clinicians to non-invasively detect early-stage liver disease — something not possible using currently available methods
Study Shows Proof of Concept of BioIVT HEPATOPAC Cultures with Targeted Assay to Evaluate
New in vitro Bioactivation Liver Response Assay used HEPATOPAC model to demonstrate utility of in vitro transcriptomic signature-based strategy in preclinical DILI risk assessment
“Game-changing” procedure shown to discontinue insulin treatment in type 2 diabetics
A revolutionary endoscopic therapeutic procedure may lead to the discontinuation of insulin treatment in a significant number of people with type 2 diabetes, new research presented today at UEG Week 2020 Virtual has shown
The world’s first successful identification and characterization of in vivo senescent cells
Cell senescence is a state of permanent cell cycle arrest that was initially defined for cells grown in cell culture. It plays a key role in age-associated organ dysfunction and age-related diseases such as cancer, but the in vivo pathogenesis…
Skoltech scientists discovered a new biomarker for liver cancer diagnosis
A group of Skoltech scientists led by a Skoltech and MSU professor Olga Dontsova discovered a novel liver-specific non-coding RNA. The researchers tracked the RNA amounts in a healthy liver and that affected by carcinogenesis and suggested using the RNA…
The heat is on for building 3D artificial organ tissues
Radiator-like fluid systems adjust the genetic wiring inside human liver cells in preliminary work toward artificial organ-tissue engineering
Senescent cells may be good when it comes to a bad injury
It’s called senescence, when stressed cells can no longer divide to make new cells, and it’s considered a factor in aging and in some diseases. Now scientists have some of the first evidence that at a younger age at least,…
Liver Transplant Team Part of National Trial to Increase Donor Pool
UC San Diego Health program offers comprehensive care with excellent outcomes Nationally, more than 12,000 people need a liver transplant, including more than 2,300 Californians. Patients can wait several years on the liver transplant wait list in California before receiving…
HHRI awarded continuation of SRTR contract
The Chronic Disease Research Group (CDRG) of the Hennepin Healthcare Research Institute (HHRI) has renewed its federal contract to operate the Scientific Registry of Transplant Recipients (SRTR).
The hormone glucagon may be a warning light for diabetes
Up to one in four Danes has an unhealthy accumulation of fat in the liver, also known as fatty liver. Fatty liver is rarely the cause of symptoms in itself, but people with fatty liver have an increased risk of…
UC San Diego Health Revives Non-Beating Donor Heart for Successful Transplantation
UC San Diego Health is the first hospital on the West Coast to perform heart transplant surgery from a donor after circulatory death using a new portable organ care system. The investigational procedure could significantly decrease transplant waiting list times and improve patient outcomes.
Researchers discover gene that could decrease likelihood of developing alcoholic cirrhosis
INDIANAPOLIS–Researchers at Indiana University School of Medicine are learning more about how a person’s genes play a role in the possibility they’ll suffer from alcoholic cirrhosis with the discovery of a gene that could make the disease less likely. Alcoholic…
Prophylactic antivirals prevent chronic HCV in patients receiving kidneys from positive donors
Embargoed News from Annals of Internal Medicine
Gene test can predict risk of medications causing liver injury
Organoid-related discovery may also help drug makers screen potential pharmaceuticals
Protein discovery could improve type 2 diabetes treatment
A world first discovery of how a protein works in the liver could lead to a more effective type 2 diabetes drug.
Premature deaths from alcoholic liver disease rising as gap between men and women narrows
Since the early 2000s, alcoholic liver disease deaths among non-Hispanic whites, particularly women, have increased more rapidly than rates among other ethnic groups., reports a new study in the American Journal of Preventive Medicine
Two discoveries boost next-generation organoid development
New research collaboration tunes into signals that will help make better organoids to mimic functions of the trachea, esophagus, stomach, liver, gallbladder, bile ducts and pancreas
When liver cirrhosis is deadly
International research group identifies three forms of disease progression for “acute decompensated liver cirrhosis”
During COVID-19, liver disease and transplant patients need targeted and sustained support
Digital ILC 2020: The liver community has been prompt in addressing the challenges of COVID-19 for liver patients – joining forces to support these patients, provide recommendations to their doctors, and keep research at the forefront.
Liver fibrosis in routine care for diabetes could uncover advanced liver disease patients
Digital ILC 2020: A pilot study from the UK has suggested that diagnosis of advanced liver disease in people living with diabetes could be increased 5-fold if the assessment of liver fibrosis is included in routine care.
Novel agents for the treatment of chronic HBV infection have cure in their sights
Digital ILC 2020: Focused viral hepatitis sessions at Digital International Liver Congress™ 2020 reveal new drugs that aim to cure chronic HBV infection
New data on emerging treatments for liver cancer raise hope for advanced disease patients
Digital ILC 2020: Promising safety results on three different novel treatments for advanced or unresectable HCC represent a further step towards new options for patients with poor prognosis
New insights into liver regeneration as a potential role for the MAGL enzyme is identified
Digital ILC 2020: As a lack of donor livers continues to restrict treatment for end-stage liver disease or acute liver failure, scientists continue to study the mechanisms of liver regeneration in order to try and harness it as a treatment modality.
New models help predict liver cancer after successful hepatitis C virus (HCV) treatment
Digital ILC 2020: European scientists develop new predictive models for HCC in patients with chronic HCV after a sustained virological response to direct-acting antiviral therapy
Prioritizing patients using MELD-Na reduces liver transplant waiting-list mortality
Digital ILC 2020: European study reports that prioritizing patients for liver transplantation using MELD-Na could reduce 90-day waiting-list mortality compared with current practice
Two novel treatments show promise in improving biomarkers of NASH pathology
Digital ILC 2020: As new data highlight the increasing prevalence of NAFLD, two new treatments have demonstrated reductions in ALT, hepatic fat and other indicators of liver disease, including in patients with type 2 diabetes
Changes in gut microbiota can greatly impact alcohol-related liver disease and cancer risk
Digital ILC 2020: Studies evaluating fecal microbial transplant and inflammatory signalling highlight the significance of gut microflora in alcohol-related liver disease and hepatocarcinogenesis
Stronger together in the microbiome: How gut microbes feed each other to overcome dietary deficiencies, change host behavior, and improve reproduction
(Title: Stronger together in the microbiome: how gut microbes feed each other to overcome dietary deficiencies, change host behavior, and improve reproduction) To study how the microbiome affects their host behavior, a group of researchers at the Champalimaud Centre for…
Pigs grow new liver in lymph nodes, study shows
PITTSBURGH, Aug. 24, 2020 – Hepatocytes — the chief functional cells of the liver — are natural regenerators, and the lymph nodes serve as a nurturing place where they can multiply. In a new study published online and appearing in…
Electronic consultations between primary providers and radiologists improve patient care
EConsults provide easy access to expert opinions, promoting collaboration between primary care providers and radiologists that ultimately improves patient care–including avoiding unnecessary imaging
How protein protects against fatty liver
Non-alcoholic fatty liver disease is the most common chronic liver disease in the world, with sometimes life-threatening consequences. A high-protein, calorie-reduced diet can cause the harmful liver fat to melt away – more effectively than a low-protein diet. A new…
TGen review suggests postmenopausal women at risk for nonalcoholic fatty liver disease
Diet, exercise and hormone therapy may potentially benefit postmenopausal women; lack of hormone replacement therapy studies called ‘a critical gap in clinical research’
First drug for hepatitis D has been approved by european commission
A chronic disease becomes treatable
Osteopontin, a protein not always as bad as it is made out to be
The UPV/EHU-University of the Basque Country shows that maintaining osteopontin delays the onset of metabolic fatty liver disease during ageing
Study to explore whether new therapy can help address problem drinking
A psychological therapy found to be effective in helping people achieve and maintain weight loss is being trialled to see if it can support patients with chronic liver disease to stop drinking. Functional Imagery Training (FIT), developed by researchers at…
Fatty liver disease despite a normal weight
Researchers from the University of Tsukuba identify differences in the clinical features of non-obese patients with non-alcoholic fatter liver disease based on their sex and body mass index
Novel diabetes drug candidate shows promising properties in human islets and mouse models
Researchers have discovered a new drug candidate that offers a major advance to treat diabetes. Tested on human and mouse pancreatic islets, mouse and rat cell cultures and animal models of Type 1 and Type 2 diabetes, the drug significantly improved four detrimental characteristics of diabetes.
American Association for the Study of Liver Diseases Foundation Announces Funding of over $2.2 Million in Research and Career Development Awards, Abstract Awards, and Emerging Liver Scholars Program
The American Association for the Study of Liver Diseases (AASLD) Foundation, the largest private supporter of liver disease research and training in the United States, today announced its combined investment of over $2.2 million in Research and Career Development Awards, Abstract Awards, and its Emerging Liver Scholars (ELS) Program.