Could a tiny fish hold the key to curing blindness?

Imagine this: A patient learns that they are losing their sight because an eye disease has damaged crucial cells in their retina. Then, under the care of their doctor, they simply grow some new retinal cells, restoring their vision.

Although science hasn’t yet delivered this happy ending, researchers are working on it – with help from the humble zebrafish. When a zebrafish loses its retinal cells, it grows new ones. This observation has encouraged scientists to try hacking the zebrafish’s innate regenerative capacity to learn how to treat human disease. That is why among the National Eye Institute’s 1,200 active research projects, nearly 80 incorporate zebrafish.

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Grant will help scientists break new ground in gene editing

A new grant from the National Institutes of Health will allow Iowa State University scientists to continue to develop gene editing technologies to model human disease in zebrafish. The research aims to build new tools to determine which genes have therapeutic potential to treat human genetic diseases that affect the cardiovascular, immune and nervous systems.

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Serum Biomarkers, Metabolite Indicators for Kidney Toxicity, Estrogenic Compound Screening, and More Featured in February 2020 Toxicological Sciences

The February 2020 issue of Toxicological Sciences includes cutting-edge research spanning the toxicological field, from molecular, biochemical, and systems toxicology and nanotoxicology to regulatory science, risk assessment, and decision-making.

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NUS researchers uncover how fish get their shape

A team of researchers from the Mechanobiology Institute at the National University of Singapore investigated the science behind the formation of the ‘V’ patterns – also known as chevron patterns – in the swimming muscles of fish. The study focused on the myotome (a group of muscles served by a spinal nerve root) that makes up most of the fish body. These fish muscles power the fish’s side-to-side swimming motion and the chevron pattern is thought to increase swimming efficiency. The research team found that these patterns do not simply arise from genetic instruction or biochemical pathways but actually require physical forces to correctly develop.

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Cyp2F2-Mediated Lung Cancer, Rapid Risk Assessment of Color Additives, and More Featured in November 2019 Toxicological Sciences

Toxicological Sciences continues to deliver cutting-edge research in toxicology in the November 2019 issue. This issue features research on computational toxicology and databases, developmental and reproductive toxicology, and more.

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