Acetaminophen May Be Less Heart-safe than Previously Thought

The common painkiller acetaminophen was found to alter proteins in the heart tissue when used regularly at moderate doses, according to a new study conducted in mice. Researchers will present their work this week at the American Physiology Summit in Long Beach, California.

Exploring How Diethylene Glycol Poisons the Kidney and the Combined Effects of St. John’s Wort and Acetaminophen on the Liver

A ToxSpotlight article in the November 2022 issue of ToxSci assesses the mechanism for cellular accumulation of diglycolic acid while another explores the effect of long-term St. John’s wort administration on acetaminophen-induced acute hepatotoxicity and the involved mechanisms.

New Approach Methodologies, Single Cell RNAseq, and More Featured in 2021 Toxicological Sciences

Toxicological Sciences delivers cutting-edge research in toxicology in the areas of clinical and translational toxicology, emerging technologies, and more in the August 2021 issue.