When the body detects a pathogen, such as bacteria or viruses, it mounts an immune system response to fight this invader. In some people, the immune system overreacts, resulting in an overactive immune response that causes the body to injure…
Tag: PHARMACEUTICAL/COMBINATORIAL CHEMISTRY
Electrochemistry opens ways for the sustainable production of sulfonamides
Researchers at Mainz University developed a new procedure for the quick, cost-effective, and environmentally-friendly production of essential substances required by the pharmaceutical industry
New technique brings the study of molecular configuration into the microscopic domain
Researchers have developed a spectroscopic microscope to enable optical measurements of molecular conformations and orientations in biological samples. The novel measurement technique allows researchers to image biological samples at the microscopic level more quickly and accurately. The new instrument is…
Exploring pieces of heart muscle that fail to compact
University of Houston researcher awarded $2.5M to study “spongy heart”
The battle against hard-to-treat fungal infections
Systemic fungal infections are much rarer than other illnesses, but they are potentially deadly, with limited options for treatment. In fact, fungi are becoming increasingly resistant to the few drugs that are available, and infections are growing more common. A…
UNF professor awarded US patent to fight cancer tumors using synthetic curcumin analogs
Dr. Kenneth Laali, University of North Florida Presidential Professor of Chemistry, has recently been awarded a US patent for his research on the synthesis of novel curcumin analogs (curcuminoids) to fight cancer tumors. The compounds that Laali has developed provide…
Protein Controlling Magnesium Identified as Therapeutic Target for Non-alcoholic Fatty Liver Disease
Patients with liver disease have significantly elevated expression of CNNM4 protein, which modulates magnesium in the liver
Researchers watch anti-cancer drug release from DNA nanostructures in real time
Findings provide insights into tunable drug delivery and new design paradigms of DNA-based drug-carriers
Bentham Science launches new journal, Current Cosmetic Science
Bentham Science is pleased to announce the launch of a new subscription-based journal, Current Cosmetic Science . The first issue of the journal will be available online by the start of the year, 2021. The journal is edited by Dr.…
Cerium sidelines silver to make drug precursor
Rice University lab’s process simplifies fluoroketone synthesis
On the line: Watching nanoparticles get in shape
New method could advance next-generation applications in medicine, cosmetics, and petroleum recovery
SLAS announces $100K graduate education fellowship grant awarded to David McIntyre of Boston University
Oak Brook, IL (USA) – The Society for Laboratory Automation and Screening (SLAS) is pleased to announce David McIntyre, Ph.D. candidate from Boston University (Boston, MA, USA), as the 2021 SLAS Graduate Education Fellowship Grant recipient. SLAS will award $50,000…
Semaglutide paired with intensive behavioral therapy showed triple weight loss vs placebo
In study at Penn Medicine and other locations, participants lost an average of 16% of starting weight, more than one-third lost 20% or more of baseline weight
SLAS and The Pistoia Alliance partner to promote life sciences startup companies
Oak Brook, IL – The Society for Laboratory Automation and Screening (SLAS) is pleased to announce a collaboration with the Pistoia Alliance to support and promote innovative life sciences start-ups and emerging companies. The SLAS Ignite Program is a multi-pronged…
Improving stroke treatment with a modified therapeutic molecule
A research team from INRS has improved the protective effect of a molecule against ischemic stroke
Selective concentration of cationic species
Sample pretreatment processes such as concentration or classification are essential to finding trace substances present in a fluid. In scientific communities recently, prolific research is being conducted on sample pretreatment techniques utilizing electrokinetics.1 However, due to the lack of commercial…
Breakthrough in organic chemistry: Asymmetric syntheses of useful, unique chiral compounds
Researchers in Japan discover a method to synthesize useful and unique compounds called N?C axially chiral compounds
New turntable-like catalytic reactor promises more sustainable chemical manufacturing
Spinning Disc Mesh Reactor developed by Bath chemical engineers could make pharmaceuticals production safer and more sustainable
Lipid epoxides target pain, inflammatory pathways in neurons
CHAMPAIGN, Ill. — When modified using a process known as epoxidation, two naturally occurring lipids are converted into potent agents that target multiple cannabinoid receptors in neurons, interrupting pathways that promote pain and inflammation, researchers report. These modified compounds, called…
Smectite promotes probiotic biofilm formation in gut for cancer immunotherapy
Scientists from Nanjing University and the University of Macau have devised a new approach to extend the survival of transplanted probiotics in vivo, enhancing the efficacy of cancer chemo-/immunotherapies in mice. The paper entitled “Smectite promotes probiotic biofilm formation in…
‘Defective’ carbon simplifies hydrogen peroxide production
Plasma processing modifies carbon black powder to catalyze valuable chemical
Understanding catalytic couplings: not all synergies are simple
New Nature Catalysis paper provides a rationalisation of the inner workings of nickel-catalysed cross-coupling reactions
Researchers produce tiny nanoparticles and reveal their inner structure for the first time
Tiny nanoparticles can be furnished with dyes and could be used for new imaging techniques, as chemists and physicists at Martin Luther University Halle-Wittenberg (MLU) show in a recent study. The researchers have also been the first to fully determine…
What rules govern the structure of membraneless organelles?
A study in Nature Communications outlines physical rules regulating the architecture of these liquid organelles
New Method for Asymmetric N,N-Acetal Synthesis Promises Advances in Drug Development
Scientists identify new method of preparing N,N-acetals with high enantiopurity using diketones, crowning a new approach to synthesizing bioactive drugs.
Bentham Science joins ORCID as member organization
Bentham Science has joined the Membership Program offered by ORCID to facilitate its stakeholders including the authors, Editorial Board Members, and their affiliating institutions. Through the ORCID Membership, Bentham Science endeavors to ensure that the researchers have a trustable connection…
Mysterious organic scum boosts chemical reaction efficiency, may reduce chemical waste
CHAMPAIGN, Ill. — Chemical manufacturers frequently use toxic solvents such as alcohols and benzene to make products like pharmaceuticals and plastics. Researchers are examining a previously overlooked and misunderstood phenomenon in the chemical reactions used to make these products. This…
Basics of chemical analysis
Technological developments involves all aspects of life, especially the fields of science, engineering, and medicine. This reflects in the students and researcher a lack of using traditional methods to learn the basics of each science. One of the conventional techniques…
Brightening the future of semiconductor-based photocatalytic processes
* The researchers have pinpointed that the true active photocatalytic species in a model ARTA reaction is a complex salt of bismuth hexabromide
Researchers to investigate chemicals in indoor air
By far the majority of the air we breathe is indoor air; yet we know very little about the cocktail of chemicals entering our bodies in this way. Researchers now want to monitor these emissions and map out the scope of harmful substances
Enhanced Recovery Efforts for Cesarean Delivery Reduce Need for Opioids by 80%
Results of study by Children’s Hospital Colorado show a third of patients not needing narcotic pain pills after c-section
Bentham Science announces the launch of journal, ‘Current Probiotics’
Bentham Science announces the launch of the subscription-based journal, Current Probiotics . The first issue of the journal will be available online in the year 2021. Dr. E.L. de Souza is the Editor-in-Chief of this new journal. Dr. E.L. de…
How COVID-19 tested and transformed science
A year into the COVID-19 pandemic, normal life has been upended and the world has endured staggering loss. Despite the myriad challenges, science has stepped up to find solutions to combat the novel coronavirus. A special issue of Chemical &…
New antifungal compound from ant farms
Attine ants are farmers, and they grow fungus as food. Pseudonocardia and Streptomyces bacteria are their farmhands, producing metabolites that protect the crop from pathogens. Surprisingly, these metabolites lack common structural features across bacteria from different geographic locations, even though…
Çukurova University (TDRAC) joins Bentham Science as institutional member
Bentham Science is pleased to announce an Institutional Member partnership with the Turkish university, Çukurova University Tropical Diseases Research and Application Center (TDRAC). The partnership provides the opportunity to the researchers, from the university, to publish their research under an…
Compound from medicinal herb kills brain-eating amoebae in lab studies
Primary amoebic meningoencephalitis (PAM), a deadly disease caused by the “brain-eating amoeba” Naegleria fowleri , is becoming more common in some areas of the world, and it has no effective treatment. Now, researchers reporting in ACS Chemical Neuroscience have found…
Single-dose COVID-19 vaccine triggers antibody response in mice
Across the world, health care workers and high-risk groups are beginning to receive COVID-19 vaccines, offering hope for a return to normalcy amidst the pandemic. However, the vaccines authorized for emergency use in the U.S. require two doses to be…
Scientists turned toxic pesticide into treatment against antibiotic-resistant bacteria
Russian scientists from Kaliningrad and St. Petersburg have synthesized nitrogen-containing cyclic compounds that differ only in the relative position of side substituents.
New catalytic approach to accessing key intermediate carbocation
IBS chemists have developed a novel multifaceted catalyst to access carbocation intermediates and convert them into useful ring-shaped molecules for pharma and chemical industries
January issue of SLAS Discovery “Cryo-EM: The Resolution Revolution and Drug Discovery”
Oak Brook, IL – The January edition of SLAS Discovery features the cover article, “Cryo-EM: The Resolution Revolution and Drug Discovery” by Taiana Maia de Oliveira, Ph.D., Lotte van Beek, Ph.D., Fiona Shilliday, Ph.D., Judit E. Debreczeni, Ph.D., and Chris…
2D material controls light twice stronger
Since the invention of world’s first laser – the ruby laser – in 1960, the human desire to control light has spread to various industries, including telecommunications, medicine, GPS, optical sensors and optical computers. Recently, a POSTECH research team has…
Researchers develop new combined process for 3D printing
Chemists at Martin Luther University Halle-Wittenberg (MLU) have developed a way to integrate liquids directly into materials during the 3D printing process. This allows, for example, active medical agents to be incorporated into pharmaceutical products or luminous liquids to be…
Can early drug intervention prevent weight gain in children with mental illness?
UH pharmacologist puts metformin to the test
Using light, red blood cells and a honey bee peptide to deliver therapeutic proteins
Protein therapies are often more potent and selective toward their biochemical targets than other types of drugs, particularly small molecules. However, proteins are also more likely to be quickly degraded by enzymes or cleared from blood by the kidneys, which…
An eventful year in pharma
As 2020 draws to a close, the global pandemic has cast an even brighter spotlight on the pharmaceutical industry. Experts have spent the year racing to develop tests, therapeutics and vaccines to diagnose and combat COVID-19, while also trying to…
Ability to predict C-diff mortality nearly doubled with new guidelines
University of Houston team assesses change to severity definitions
Luxembourg researchers receive prestigious international award
2019 Galien Prize in Pharmacology awarded to Luxembourg Institute of Health (LIH) scientists
Vitamin boosts essential synthetic chemistry
Rice lab discovers light-driven catalyst forms olefins for drug, agrochemical manufacturing
Useful ‘fake’ peptides
Oligourea foldamers mimic peptides’ alpha-helices and effectively bind to drug targets
Artificial intelligence collaboration seeking to hasten COVID-19 insights
WEST LAFAYETTE, Ind. – During the COVID-19 pandemic, health care professionals and researchers have been confined mostly to using local and national datasets to study the impact of comorbidities, pre-existing medication use, demographics and various interventions on disease course. Now,…