news, journals and articles from all over the world.
New research by scientists at University of California San Diego has shown that cells regulate cAMP/PKA signaling by forming liquid droplets that segregate excess PKA catalytic subunits where they can do no harm. Some cancers may block the formation of liquid droplets, leading to hyperactive signaling and tumor formation.
Chronic kidney disease is linked to the formation of mineral deposits on blood vessel walls, known as “calcification”, causing cardiovascular disease.
UC San Diego researchers describe the underlying signaling pathway that results in pulmonary arterial hypertension and a novel monoclonal antibody therapy that blocks the abnormal blood vessel formation characterizing the disease.
The May 2022 issue of Toxicological Sciences, the Society of Toxicology’s official journal, is now available and features leading research in carcinogenesis, computational toxicology and databases, and more.
Article title: Regression from pathological hypertrophy in mice is sexually dimorphic and stimulus-specific Authors: Deanna L. Muehleman, Claudia Crocini, Alison R. Swearingen, Christopher D. Ozeroff, Leslie A. Leinwand From the authors: “This work highlights that the reversal of pathological hypertrophy…
Article title: Dilated cardiomyopathy mutations in thin-filament regulatory proteins reduce contractility, suppress systolic Ca2+, and activate NFAT and Akt signaling Authors: Paul Robinson, Alexander J. Sparrow, Suketu Patel, Marta Malinowska, Svetlana N. Reilly, Yin-Hua Zhang, Barbara Casadei, Hugh Watkins, Charles Redwood…
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