Flozin Drugs Lower Salt-Induced Hypertension, Maintain Circadian Rhythm in Rats

Article title: SGLT2 inhibition effect on salt-induced hypertension, RAAS and Na+ transport in Dahl SS rats Authors: Olha Kravtsova, Ruslan Bohovyk, Vladislav Levchenko, Oleg Palygin, Christine A. Klemens, Timo Rieg, Alexander Staruschenko From the authors: “The main findings of the…

Seizures in the Canadian Arctic: A public health crisis, hidden in plain sight

He set out to research the effect of polar day-night patterns on seizure frequency and epilepsy. He found something he never expected: a public health crisis in one of the wealthiest countries in the world, relevant to geographically isolated communities and Indigenous peoples.

Could a Novel Light Therapy Help People With Alzheimers?

Recently, the National Institutes of Health (NIH) awarded researchers at the Icahn School of Medicine at Mount Sinai a five-year grant to out whether exposing patients to a combination of light therapies will slow Alzheimer’s debilitating effects.

“Springing forward” affects early birds less than night owls, study finds

Every spring, the Daylight Saving Time shift robs people of an hour of sleep – and a new study shows that DNA plays a role in how much the time change affects individuals. People whose genetic profile makes them more likely to be “early birds” can adjust to the time change in a few days. But those who tend to be “night owls” could take more than a week to get back on track.

Successful DNA replication in cyanobacteria depends on the circadian clock

A new study from the University of Chicago has found that the photosynthetic bacterium Synechococcus elongatus uses a circadian clock to precisely time DNA replication, and that interrupting this circadian rhythm prevents replication from completing and leaves chromosomes unfinished overnight.

Ditching the daylight saving time change for better sleep, health and safety

If the month of March has you dreading the night when we “spring forward” to daylight saving time, you’re not alone. More than half of Americans say they’re tired after the time change, and 63% of Americans say that they support the elimination of seasonal time changes in favor of a national, fixed, year-round time. According to the American Academy of Sleep Medicine, research supports public opposition to seasonal time changes, and sleep science suggests that permanent standard time is the best option.

Shift Work Disrupts Kidney Rhythms, Contributes to Kidney and Heart Disease

Article title: Environmental circadian disruption suppresses rhythms in kidney function and accelerates excretion of renal injury markers in urine of male hypertensive rats Authors: Atlantis M. Hill, G. Ryan Crislip, Adam Stowie, Ivory Ellis, Anne Ramsey, Oscar Castanon-Cervantes, Michelle L.…

Against the Clock: Circadian Rhythm Genes in Key Brain Region are Involved in Binge Drinking

Researchers have identified a causal link between binge drinking and circadian clock genes in a brain region previously implicated in hazardous alcohol use. Binge drinking is a common and harmful pattern of alcohol use, responsible for more than half of alcohol-related deaths. There is already robust evidence that genes involved in controlling circadian rhythm — the body’s natural processes that follow a 24 hour light/dark cycle — are associated with hazardous drinking and alcohol abuse. However, it is not known which areas of the brain mediate the clock genes’ effects on drinking. A brain region known as the nucleus accumbens shell (NAcSh) is already noted for its role in risky drinking; the region forms part of the brain’s ‘reward system’, reinforcing the use of alcohol and other addictive substances by release of dopamine. In the new study, reported in Alcoholism: Clinical and Experimental Research, scientists investigated whether clock genes in the NAcSh are involved in regulating

On nights before a full moon, people go to bed later and sleep less, study shows

Sleep cycles in people oscillate during the 29.5-day lunar cycle: In the days leading up to a full moon, people go to sleep later in the evening and sleep for shorter periods of time. Scientists observed these oscillations in urban and rural settings — regardless of an individual’s access to electricity.

MRI Finds Circadian Variations in Men’s and Women’s Renal Blood Flow

Article title: Circadian variation in renal blood flow and kidney function in healthy volunteers monitored with noninvasive magnetic resonance imaging Authors: Per Eckerbom, Peter Hansell, Eleanor Cox, Charlotte Buchanan, Jan Weis, Fredrik Palm, Susan Francis, Per Liss From the authors: “In…

Pinpointing The Cells That Keep The Body’s Master Circadian Clock Ticking

DALLAS – Aug. 7, 2020 – UT Southwestern scientists have developed a genetically engineered mouse and imaging system that lets them visualize fluctuations in the circadian clocks of cell types in mice. The method, described online in the journal Neuron, gives new insight into which brain cells are important in maintaining the body’s master circadian clock. But they say the approach will also be broadly useful for answering questions about the daily rhythms of cells throughout the body.

Time of day differences in neural reward responsiveness in children

The Reward Positivity (∆RewP) event-related potential (ERP), generally quantified as the difference between neural responsiveness to monetary gains (RewP-Gain) and losses (RewP-Loss) is commonly used as an index of neural reward responsiveness. Despite the popularity of this ERP component in…