Mount Sinai researchers have discovered that Polycomb complexes, groups of proteins that maintain gene expression patterns, are essential for proper skin development, according to a paper published in Genes & Development on February 18.
COVID-19 is caused by the virus SARS-CoV-2, which is structurally similar to the viruses that cause SARS-CoV and MERS-CoV. In The Journal of Chemical Physics, scientists report molecular-level investigations of these viruses, providing a possible pathway to antiviral drugs to fight the diseases. They looked at a viral protein that plays a role in the virus’s ability to replicate and in defeating the host’s immune system, making it an attractive target for potential drug treatments.
Researchers from the National University of Singapore have identified a new avenue to maintain bone health, which opens up new and potentially more effective osteoporosis treatments.
As the COVID-19 pandemic continues to spread, many researchers are studying epidemiological models to predict its propagation. However, a mathematician and expert in complex systems decided to focus on finding targets within SARS-CoV-2 for new drugs to attack. In the journal Chaos, he discusses the dramatic increase in the sensitivity of the main protease of SARS-CoV-2 to small disturbances, which made him suspect there is a role for inhibitors to play in killing the virus.
Researchers at the GW Cancer Center have identified the protein ERK as an important mechanism behind platinum-resistance in platinum-resistant ovarian cancer. The study is published in Clinical Cancer Research.