New research shows how one transcription factor functions as a special “pioneer factor” by managing to bind to a blocked segment of DNA to begin the process of opening up and activating a gene.
Tag: Dna Binding
Murine CD4+ T cells exhibit sexually dimorphic responses to estrogen signaling
Many autoimmune diseases exhibit sexual dimorphism. 17ẞ-estradiol (estrogen, “E2”), a steroid sex hormone primarily known for its reproductive roles, has also been shown to modulate CD4+ T cells. E2 signals through two nuclear receptors, ERα and ERẞ, which regulate gene…