Article title: Sex differences in cardiovascular disease and dysregulation in Down syndrome Authors: Melissa L. Bates, Anastasiia Vasileva, Laura D.M. Flores, Yana Pryakhina, Michelle Buckman, Michael H. Tomasson, Lara R. DeRuisseau From the authors: “Based on the results of our…
Tag: Physiology
Diabetes Drug Improves Kidney Function and Inflammation
Article title: Reno-protective effects of empagliflozin are linked to activation of the tubuloglomerular feedback mechanism and blunting of the complement system Authors: Xin Chen, Denis Delić, Yaochen Cao, Linghong Shen, Qin Shao, Zheyu Zhang, Hongwei Wu, Ahmed A. Hasan, Christoph…
Succinate Protects against Obesity, Metabolic Disease through Brown Fat Protein Expression
Article title: Exogenous succinate impacts mouse brown adipose tissue mitochondrial proteome and potentiates body mass reduction induced by liraglutide Authors: Rodrigo S. Gaspar, Jeany Delafiori, Giuliana Zuccoli, Victor Corasolla Carregari, Thais P. Prado, Joseane Morari, Davi Sidarta-Oliveira, Carina S. Solon,…
Mothers’ Obesity Damages Blood-brain Barrier in Offspring, Lean Foster Mothers’ Milk May Be Preventive Tool
Article title: Maternal obesity damages the median eminence blood-brain barrier structure and function in the progeny: the beneficial impact of cross-fostering by lean mothers Authors: Roberta Haddad-Tóvolli, Joseane Morari, Roberta Barbizan, Vanessa C. Bóbbo, Rodrigo S. Carraro, Carina Solon, Nathalia…
Researchers Use Colon Organoids to Explore Why Aspirin Protects against Cancer
Article title: Genomic and epigenomic responses to aspirin in human colonic organoids Authors: David Witonsky, Margaret C. Bielski, Jinchao Li, Kristi M. Lawrence, Ishmael N. Mendoza, Hina Usman, Sonia S. Kupfer From the authors: “This is the first study to…
Microvascular Impairment Caused by Chronic Estrogen Exposure Is Sex-specific
Article title: 17β-estradiol promotes sex-specific dysfunction in isolated human arterioles Authors: Gopika SenthilKumar, Boran Katunaric, Henry Bordas-Murphy, Micaela Young, Erin L. Doren, Mary E. Schulz, Michael E. Widlansky, Julie K. Freed From the authors: “To our knowledge, this is the…
Study Explores How Pressure in the Skull Affects Brain Blood Flow after Brain Injury
Article title: Contribution of intracranial pressure to human dynamic cerebral autoregulation after acute brain injury Authors: Sérgio Brasil, Ricardo C. Nogueira, Angela S. M. Salinet, Márcia H. Yoshikawa, Manoel J. Teixeira, Wellingson Paiva, Luiz M. S. Malbouisson, Edson Bor-Seng-Shu, Ronney…
Researchers ID Protein Crucial to Lung Endothelial Function, Could Lead to Targeted Treatment for Fibrosis
Article title: The matricellular protein CCN3 supports lung endothelial homeostasis and function Authors: Kalpana R. Betageri, Patrick A. Link, Andrew J. Haak, Giovanni Ligresti, Daniel J. Tschumperlin, Nunzia Caporarello From the authors: “Altogether, our results demonstrate that the matricellular protein…
Women with Obesity and Type 2 Diabetes May Improve Vascular Insulin Resistance through Weight Loss
Article title: Impact of sex and diet-induced weight loss on vascular insulin sensitivity in type 2 diabetes Authors: Camila Manrique-Acevedo, Rogerio Nogueira Soares, James A. Smith, Lauren K. Park, Katherine Burr, Francisco I. Ramirez-Perez, Neil J. McMillan, Larissa Ferreira-Santos, Neekun…
Kids with Cerebral Palsy Have More Small Muscle Fibers, More Stem Cells in Contractured Muscles
Article title: Resident muscle stem myogenic characteristics in postnatal muscle growth impairments in children with cerebral palsy Authors: Ryan E. Kahn, Timothy Krater, Jill E. Larson, Marysol Encarnacion, Tasos Karakostas, Neeraj M. Patel, Vineeta T Swaroop, Sudarshan Dayanidhi From the…
Your Gut’s Microbiome, On a Chip
In APL Bioengineering, researchers describe how gut-on-a-chip devices can bridge lab models and human biology. Modeling the microbiome is particularly difficult because of its unique environmental conditions, but through creative design, gut-on-a-chip devices can simulate many of these properties, such as the gut’s anaerobic atmosphere, fluid flow, and pulses of contraction/relaxation. Growing intestinal cells in this environment means that they more closely resemble human biology compared to standard laboratory cell cultures.
Mathematical modeling links odor-responsive behavior, neural activity, and genes
Humans and animals detect different stimuli such as light, sound, and odor through nerve cells, which then transmit the information to the brain.
Coconut Sugar May Lower Blood Pressure, Artery Stiffness in Older Adults
A first-of-its-kind study finds a natural coconut sugar may help reduce the risk of cardiovascular disease by improving blood vessel health and managing high blood pressure. The study is published ahead of print in the Journal of Applied Physiology.
Review Offers Multisystem Perspective of Frailty and Stresses Need for More Research
Article title: Multisystem physiological perspective of human frailty and its modulation by physical activity Authors: Joseph A. Taylor, Paul L. Greenhaff, David B. Bartlett, Thomas A. Jackson, Niharika A. Duggal, Janet M. Lord From the authors: “In summary, frailty is a…
Omics and AI May Help Predict Lung Disease Risk in Premature Babies
Article title: Development of a peripheral blood transcriptomic gene signature to predict bronchopulmonary dysplasia Authors: Alvaro Moreira, Miriam Tovar, Alisha M. Smith, Grace C. Lee, Justin A. Meunier, Zoya Cheema, Axel Moreira, Caitlyn Winter, Shamimunisa B. Mustafa, Steven Seidner, Tina…
Researchers ID Protein as Mitochondrial Homeostasis Regulator
Article title: A20 binding and inhibitor of nuclear factor kappa B (NF-κB)-1 (ABIN-1)—a novel modulator of mitochondrial autophagy Authors: Rosetta Merline, Heiko Rödig, Jinyang Zeng-Brouwers, Chiara Poluzzi, Georg Tascher, Jonas Michaelis, Jaime Lopez-Mosqueda, Andrew Rhiner, Lisa Sophie Huber, Valentina Diehl,…
Researchers Explore Additional Pathways that May Contribute to Aneurysm Formation
Article title: Ecto-5′-nucleotidase (Nt5e/CD73)-mediated adenosine signaling attenuates TGFβ-2 induced elastin and cellular contraction Authors: Rolando A. Cuevas, Ryan Wong, Pouya Joolharzadeh, William J. Moorhead III, Claire C. Chu, Jack Callahan IV, Alex Crane, Camille K. Boufford, Angelina M. Parise, Aneesha…
Fatty Acid May Be Useful in Preventing Kidney Fibrosis, Treating Fibrotic Diseases
Article title: Epoxyeicosatrienoic acid administration or soluble epoxide hydrolase inhibition attenuates renal fibrogenesis in obstructive nephropathy Authors: Mi Ra Noh, Hee-Seong Jang, Fadi E. Salem, Fernando A. Ferrer, Jinu Kim, Babu J. Padanilam From the authors: “Our findings provide a…
Tissue- and Cell-specific Properties of Specialized Cells Affect How Quickly Tumors Form in Intestinal Cancer
Article title: Tissue and cell specific properties of enterochromaffin cells affect the fate of tumorigenesis toward non-endocrine adenocarcinoma of the small intestine Authors: Yoshitatsu Sei, Jianying Feng, Xilin Zhao, Pradeep Dagur, J. Philip McCoy, Juanita L. Merchant, Stephen A. Wank…
Researchers ID Protein Involved in Regulating Gastrointestinal Function
Article title: Proteolipid protein 1 is involved in the regulation of intestinal motility and barrier function in the mouse Authors: Crystal Woods, Amanda R. Flockton, Laurie E. Wallace, Catherine M. Keenan, Wendy B. Macklin, Keith A. Sharkey, Jaime Belkind-Gerson From…
F1 driver seat ‘avatar’ has potential to improve comfort and performance
Formula 1 team Williams Racing has partnered with University experts to develop the first-known driver seat using pioneering biomechanics technology
Researchers Identify How HIV/Hepatitis Drug Harms the Kidneys
A first-of-its-kind study identifies mechanisms that explain how a drug commonly used to treat HIV and hepatitis causes kidney disease and kidney injury. The study is published ahead of print in Function.
Researchers ID Kidney Pathway Involved with Autoimmune-related Hypertension in Female Mice
Article title: Renal TLR-7/ TNF-α pathway as a potential female-specific mechanism in the pathogenesis of autoimmune-induced hypertension Authors: Sarika Chaudhari, Bradley M. D’Souza, Jessica Y. Morales, Cassandra M. Young-Stubbs, Caroline G. Shimoura, Rong Ma, Keisa W. Mathis From the authors:…
Study Evaluates Neural Network Involvement in PTSD
Article title: The brain landscape of the two-hit model of posttraumatic stress disorder Authors: Lisa M. James, Brian E. Engdahl, Peka Christova, Scott M. Lewis, and Apostolos P. Georgopoulos From the authors: “The present study provides a novel contribution by…
Sex Plays a Role in Lung Cell Development after High Oxygen Exposure
Article title: Remarkable sex-specific differences at single-cell resolution in neonatal hyperoxic lung injury Authors: Abiud Cantu, Connor Leek, Eniko Sajti, Krithika Lingappan, Manuel C. Gutierrez, Xiaoyu Dong From the authors: “Exploring the basis behind sex-specific differences will be crucial to…
Exercise during Pregnancy Offsets Risks to Fetus from Maternal Obesity
Article title: Maternal exercise improves epithelial development of fetal intestine by enhancing apelin signaling and oxidative metabolism Authors: Song Ah Chae, Jun Seok Son, Jeanene Marie de Avila, Min Du, Mei-Jun Zhu From the authors: “These findings suggest that [maternal…
Researchers ID Role of Enzyme as Regulator of Inflammation in Lung Disease
Article title: Pim-1 kinase is a positive feedback regulator of the senescent lung fibroblast inflammatory secretome Authors: Ashley Y. Gao, Ana M. Diaz Espinosa, Fiorenza Gianì, Tho X. Pham, Chase M. Carver, Aja Aravamudhan, Colleen M. Bartman, Giovanni Ligresti, Nunzia…
RNA Sequencing of Whole Blood in Female Triathletes Explores Effects of Endurance Exercise on Gene Expression
Article title: Whole blood transcriptome characterization of young female triathlon athletes following an endurance exercise: a pilot study Authors: Attila Bácsi, András Penyige, Gergely Becs, Szilvia Benkő, Elek Gergő Kovács, Csaba Jenei, István Pócsi, József Balla, László Csernoch, Ildikó Balatoni…
New Machine Learning Calculations May Predict Narrowing of Coronary Artery
Article title: Deep learning-based prediction of coronary artery stenosis resistance Authors: Hao Sun, Jincheng Liu, Yili Feng, Xiaolu Xi, Ke Xu, Liyuan Zhang, Jian Liu, Bao Li, Youjun Liu From the authors: “The present study proposed a method to predict…
Proteins That Bind Together and Promote Autophagy May Underlie Alzheimer’s Disease Progression
Article title: C-terminal fragment of APP interacts with p62, forms an aggregate, and induces autophagic degradation in Alzheimer’s cell model Authors: Keigo Tanaka, Kohei Kuramoto, Tadashi Nakagawa, Yasuyuki Nomura, Koichiro Ozawa, Toru Hosoi From the authors: “Overall, our results suggest…
Study Explores Heritability of Brain Signal Variability
Article title: Heritability of brain neurovascular coupling Authors: Peka Christova, Kâmil Uğurbil, Apostolos P. Georgopoulos From the authors: “Here we show that the sample-to-sample turnover of the resting state fMRI blood-oxygen-level-dependent turnover (TBOLD) is heritable, the left and right hemisphere…
‘Molecular Motor’ Protein Essential for Complex Protein Distribution in Intestinal Cells
Article title: Myosin 5b is required for proper localization of the intermicrovillar adhesion complex in the intestinal brush border Authors: Sarah A. Dooley, Kristen A. Engevik, Jessica Digrazia, Rachel Stubler, Izumi Kaji, Evan Krystofiak, Amy C. Engevik From the authors:…
Protein Alters Expression of Extracellular Vesicle Pathway in Colorectal Cancer, Could Serve as Diagnostic Tool
Article title: IMP1/IGF2BP1 in human colorectal cancer extracellular vesicles Authors: Madeline Kuhn, Yang Zhang, John Favate, Mayu Morita, Aurora Blucher, Sukanya Das, Shun Liang, Ranjan Preet, Louis R. Parham, Kathy N. Williams, Sudheer Molugu, Randall J. Armstrong, Wei Zhang, Jiegang…
UTSW scientists identify brain circuit that triggers rare, blood sugar-dependent epilepsy
A small group of brain cells linked in a circuit is responsible for setting off whole-brain seizures in a rare form of epilepsy affected by blood sugar levels, a study led by UT Southwestern researchers suggests. The finding, published in Science Translational Medicine, could lead to new treatments for other metabolic disorders in the brain, the authors said.
APS Porter Physiology Development Fellowship Honored with an Association Impact Award
The American Physiological Society’s (APS) Porter Physiology Development Fellowship, the Society’s flagship diversity program, has been honored with an inaugural Impact Award from the Software & Information Industry Association’s (SIIA) Associations, Media and Publishing (AM&P) Network.
Sigmund, Yosten Win Prestigious Awards Recognizing Excellence in Physiological Research
The Society’s Executive Cabinet has announced that Curt D. Sigmund, PhD, FAPS, of the Medical College of Wisconsin, has received the 2023 Walter B. Cannon Award, and Gina L.C. Yosten, PhD, of Saint Louis University, has received the 2023 Henry Pickering Bowditch Award Lecture.
Study Reveals Additional Representation through Brain’s Somatomotor System
Article title: A third somatomotor representation in the human cerebellum Authors: Noam Saadon-Grosman, Peter A. Angeli, Lauren M. DiNicola, Randy L. Buckner From the authors: “We provide reliable evidence that the human cerebellum possesses three spatially distinct representations of the…
Researchers ID Gene and Protein Involved in Muscle Wasting, Could Lead to Targeted Treatment
Article title: Pathophysiological levels of GDF11 activate Smad2/Smad3 signaling and induce muscle atrophy in human iPSC-derived myocytes Authors: Mikako Honda, Takumi Makino, Xiaolin Zhao, Mariko Matsuto, Hidetoshi Sakurai, Yu Takahashi, Makoto Shimizu, Ryuichiro Sato, Yoshio Yamauchi From the authors: “In…
Researchers ID Pathway Involved in Inflammatory Bladder Damage in Mouse Model of Type 1 Diabetes
Article title: Diabetes causes NLRP3-dependent barrier dysfunction in mice with detrusor overactivity but not underactivity Authors: Michael R. Odom, Francis M. Hughes Jr., Huixia Jin, J. Todd Purves From the authors: “This is the first study to demonstrate that NLRP3-mediated…
Biological Sex, Heart Disease Risk Factors Can Influence Relationship between Cardiorespiratory Fitness Level and Brain Blood Flow
Article title: Influence of sex and presence of cardiovascular risk factors on relations between cardiorespiratory fitness and cerebrovascular hemodynamics Authors: Wesley K. Lefferts, Cynthia M. Weiner, Sara E. Mascone, Jacqueline A. Augustine, Kevin S. Heffernan, Elizabeth C. Lefferts From the…
Changing Hormone Levels Post-menopause Leads to Vascular Impairment in Female Mice
Article title: Cerebral arteriolar and neurovascular dysfunction after chemically induced menopause in mice Authors: Jade A. Blackwell, Josiane F. Silva, Emma M. Louis, Andrea Savu, Tally M. Largent-Milnes, Heddwen L. Brooks, Paulo W. Pires From the authors: “Together, our data…
Researchers ID a Protein that Could Help Stop Cancerous Tumor Development
Article title: Decorin evokes reversible mitochondrial depolarization in carcinoma and vascular endothelial cells Authors: Thomas Neill, Christopher Xie, Renato V. Iozzo From the authors: “In conclusion, we have delineated a molecular axis focused on delivering prodepolarization signals to the mitochondrial…
New Research on Neuronal Response to Calcium Imaging Aid Interpretation of Data without Electrophysiology Recordings
Article title: Simultaneous whole-cell patch-clamp and calcium imaging on myenteric neurons Authors: Zhiling Li, Werend Boesmans, Youcef Kazwiny, Marlene M. Hao, Pieter Vanden Berghe From the authors: “Our findings will help in the interpretation of calcium imaging data without the…
Substance in Urine May Help Determine Asthma Severity
Article title: Urinary total conjugated 3-bromotyrosine, asthma severity and exacerbation risk Authors: Zeneng Wang, Weiling Xu, Suzy A. A. Comhair, Xiaoming Fu, Zhili Shao, Rebecca Bearden, Joe G. Zein, Eugene R. Bleecker, Mario Castro, Loren C. Denlinger, John V. Fahy,…
Math Model Shows Climate Change Puts Rainforest Animal’s Survival in Jeopardy
A South American marsupial with ties to an ancient line of animals may go extinct in the next half-century due to warming temperatures. Researchers from the Universidad Austral de Chile will present a mathematical model of the monito del monte’s survival predictions this week at the American Physiological Society (APS) Intersociety Meeting in Comparative Physiology: From Organism to Omics in an Uncertain World conference in San Diego.
It’s Not the Heat, It’s the Humidity: Water Loss Hurts Bees Most in the Desert
Digger bees lose large amounts of water during flight, which compromises their activity period and survival in the desert heat. Researchers from Arizona State University will present their work this week at the American Physiological Society (APS) Intersociety Meeting in Comparative Physiology: From Organism to Omics in an Uncertain World conference in San Diego.
Activity ‘Snacks’ Following Meals May Help Maintain Muscle Mass
Interrupting prolonged sitting with periodic activity “snacks” may help maintain muscle mass and quality, according to a new study by researchers at the University of Toronto.
Reduced Expression of Extracellular Matrix Protein May Ease Markers of Sclerosis-associated Lung Disease
Article title: Fibronectin-EDA accumulates via reduced ubiquitination downstream of toll-like receptor 9 activation in SSc-ILD fibroblasts Authors: Ferhan Tuncer, Melissa Bulik, John Villandre, Travis Lear, Yanwen Chen, Beyza Tuncer, Daniel J. Kass, Eleanor Valenzi, Christina Morse, John Sembrat II, Robert…
Researchers Identify Potential New Therapeutic Target for Polycystic Kidney Disease
Article title: The lonidamine derivative H2-gamendazole reduces cyst formation in polycystic kidney disease Authors: Shirin V. Sundar, Julie Xia Zhou, Brenda S. Magenheimer, Gail A. Reif, Darren P. Wallace, Gunda I. Georg, Sudhakar R. Jakkaraj, Joseph S. Tash, Alan S.L.…
Inspiratory Capacity Important Marker for Disease Outcomes in COPD
Article title: Physiological predictors of morbidity and mortality in COPD: the relative importance of reduced inspiratory capacity and inspiratory muscle strength Authors: Devin B. Phillips, Matthew D. James, Conor D. O’Donnell, Sandra G. Vincent, Katherine A. Webb, Juan P. de-Torres,…