Researchers Explore Sex Differences in Cardiovascular and Congenital Heart Diseases in People with Down Syndrome

Article title: Sex differences in cardiovascular disease and dysregulation in Down syndrome Authors: Melissa L. Bates, Anastasiia Vasileva, Laura D.M. Flores, Yana Pryakhina, Michelle Buckman, Michael H. Tomasson, Lara R. DeRuisseau From the authors: “Based on the results of our…

Succinate Protects against Obesity, Metabolic Disease through Brown Fat Protein Expression

Article title: Exogenous succinate impacts mouse brown adipose tissue mitochondrial proteome and potentiates body mass reduction induced by liraglutide Authors: Rodrigo S. Gaspar, Jeany Delafiori, Giuliana Zuccoli, Victor Corasolla Carregari, Thais P. Prado, Joseane Morari, Davi Sidarta-Oliveira, Carina S. Solon,…

Mothers’ Obesity Damages Blood-brain Barrier in Offspring, Lean Foster Mothers’ Milk May Be Preventive Tool

Article title: Maternal obesity damages the median eminence blood-brain barrier structure and function in the progeny: the beneficial impact of cross-fostering by lean mothers Authors: Roberta Haddad-Tóvolli, Joseane Morari, Roberta Barbizan, Vanessa C. Bóbbo, Rodrigo S. Carraro, Carina Solon, Nathalia…

Microvascular Impairment Caused by Chronic Estrogen Exposure Is Sex-specific

Article title: 17β-estradiol promotes sex-specific dysfunction in isolated human arterioles Authors: Gopika SenthilKumar, Boran Katunaric, Henry Bordas-Murphy, Micaela Young, Erin L. Doren, Mary E. Schulz, Michael E. Widlansky, Julie K. Freed From the authors: “To our knowledge, this is the…

Women with Obesity and Type 2 Diabetes May Improve Vascular Insulin Resistance through Weight Loss

Article title: Impact of sex and diet-induced weight loss on vascular insulin sensitivity in type 2 diabetes Authors: Camila Manrique-Acevedo, Rogerio Nogueira Soares, James A. Smith, Lauren K. Park, Katherine Burr, Francisco I. Ramirez-Perez, Neil J. McMillan, Larissa Ferreira-Santos, Neekun…

Kids with Cerebral Palsy Have More Small Muscle Fibers, More Stem Cells in Contractured Muscles

Article title: Resident muscle stem myogenic characteristics in postnatal muscle growth impairments in children with cerebral palsy Authors: Ryan E. Kahn, Timothy Krater, Jill E. Larson, Marysol Encarnacion, Tasos Karakostas, Neeraj M. Patel, Vineeta T Swaroop, Sudarshan Dayanidhi From the…

Your Gut’s Microbiome, On a Chip

In APL Bioengineering, researchers describe how gut-on-a-chip devices can bridge lab models and human biology. Modeling the microbiome is particularly difficult because of its unique environmental conditions, but through creative design, gut-on-a-chip devices can simulate many of these properties, such as the gut’s anaerobic atmosphere, fluid flow, and pulses of contraction/relaxation. Growing intestinal cells in this environment means that they more closely resemble human biology compared to standard laboratory cell cultures.

Omics and AI May Help Predict Lung Disease Risk in Premature Babies

Article title: Development of a peripheral blood transcriptomic gene signature to predict bronchopulmonary dysplasia Authors: Alvaro Moreira, Miriam Tovar, Alisha M. Smith, Grace C. Lee, Justin A. Meunier, Zoya Cheema, Axel Moreira, Caitlyn Winter, Shamimunisa B. Mustafa, Steven Seidner, Tina…

Researchers ID Kidney Pathway Involved with Autoimmune-related Hypertension in Female Mice

Article title: Renal TLR-7/ TNF-α pathway as a potential female-specific mechanism in the pathogenesis of autoimmune-induced hypertension Authors: Sarika Chaudhari, Bradley M. D’Souza, Jessica Y. Morales, Cassandra M. Young-Stubbs, Caroline G. Shimoura, Rong Ma, Keisa W. Mathis From the authors:…

RNA Sequencing of Whole Blood in Female Triathletes Explores Effects of Endurance Exercise on Gene Expression

Article title: Whole blood transcriptome characterization of young female triathlon athletes following an endurance exercise: a pilot study Authors: Attila Bácsi, András Penyige, Gergely Becs, Szilvia Benkő, Elek Gergő Kovács, Csaba Jenei, István Pócsi, József Balla, László Csernoch, Ildikó Balatoni…

Protein Alters Expression of Extracellular Vesicle Pathway in Colorectal Cancer, Could Serve as Diagnostic Tool

Article title: IMP1/IGF2BP1 in human colorectal cancer extracellular vesicles Authors: Madeline Kuhn, Yang Zhang, John Favate, Mayu Morita, Aurora Blucher, Sukanya Das, Shun Liang, Ranjan Preet, Louis R. Parham, Kathy N. Williams, Sudheer Molugu, Randall J. Armstrong, Wei Zhang, Jiegang…

UTSW scientists identify brain circuit that triggers rare, blood sugar-dependent epilepsy

A small group of brain cells linked in a circuit is responsible for setting off whole-brain seizures in a rare form of epilepsy affected by blood sugar levels, a study led by UT Southwestern researchers suggests. The finding, published in Science Translational Medicine, could lead to new treatments for other metabolic disorders in the brain, the authors said.

APS Porter Physiology Development Fellowship Honored with an Association Impact Award

The American Physiological Society’s (APS) Porter Physiology Development Fellowship, the Society’s flagship diversity program, has been honored with an inaugural Impact Award from the Software & Information Industry Association’s (SIIA) Associations, Media and Publishing (AM&P) Network.

Biological Sex, Heart Disease Risk Factors Can Influence Relationship between Cardiorespiratory Fitness Level and Brain Blood Flow

Article title: Influence of sex and presence of cardiovascular risk factors on relations between cardiorespiratory fitness and cerebrovascular hemodynamics Authors: Wesley K. Lefferts, Cynthia M. Weiner, Sara E. Mascone, Jacqueline A. Augustine, Kevin S. Heffernan, Elizabeth C. Lefferts From the…

New Research on Neuronal Response to Calcium Imaging Aid Interpretation of Data without Electrophysiology Recordings

Article title: Simultaneous whole-cell patch-clamp and calcium imaging on myenteric neurons Authors: Zhiling Li, Werend Boesmans, Youcef Kazwiny, Marlene M. Hao, Pieter Vanden Berghe From the authors: “Our findings will help in the interpretation of calcium imaging data without the…

Math Model Shows Climate Change Puts Rainforest Animal’s Survival in Jeopardy

A South American marsupial with ties to an ancient line of animals may go extinct in the next half-century due to warming temperatures. Researchers from the Universidad Austral de Chile will present a mathematical model of the monito del monte’s survival predictions this week at the American Physiological Society (APS) Intersociety Meeting in Comparative Physiology: From Organism to Omics in an Uncertain World conference in San Diego.

It’s Not the Heat, It’s the Humidity: Water Loss Hurts Bees Most in the Desert

Digger bees lose large amounts of water during flight, which compromises their activity period and survival in the desert heat. Researchers from Arizona State University will present their work this week at the American Physiological Society (APS) Intersociety Meeting in Comparative Physiology: From Organism to Omics in an Uncertain World conference in San Diego.

Reduced Expression of Extracellular Matrix Protein May Ease Markers of Sclerosis-associated Lung Disease

Article title: Fibronectin-EDA accumulates via reduced ubiquitination downstream of toll-like receptor 9 activation in SSc-ILD fibroblasts Authors: Ferhan Tuncer, Melissa Bulik, John Villandre, Travis Lear, Yanwen Chen, Beyza Tuncer, Daniel J. Kass, Eleanor Valenzi, Christina Morse, John Sembrat II, Robert…