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UrduSurprising findings from a study in Nature Medicine suggest that the burden of C. diff infection may be less a matter of hospital transmission and more a result of characteristics associated with the patients themselves.
Tag: C. Difficile
CHOP Researchers Reveal How NSAIDs Worsen C. difficile Infections
Why do nonsteroidal anti-inflammatory drugs (NSAIDs) exacerbate gastrointestinal infections by Clostridioides difficile, the leading cause of antibiotic-associated diarrhea worldwide? In a new paper published in Science Advances, researchers at Children’s Hospital of Philadelphia (CHOP) have begun to answer that question, showing that NSAIDs disrupt the mitochondria of cells lining the colon, sensitizing them to damage by pathogenic toxins.
Scientists make critical progress toward preventing C. diff infections
A new study identified a compound that prevents C. diff infection. Researchers are now using this compound to develop new drug candidates that might eventually offer a way to prevent serious C. diff infections.
Study Reveals Genetic Diversity of a Particularly Problematic Pathogen
Researchers at UC San Diego have used a systems biology approach to parse the genetic diversity of Clostridioides difficile, a particularly problematic pathogen, particularly in health care settings.
MD Anderson Research Highlights for August 25, 2021
The University of Texas MD Anderson Cancer Center’s Research Highlights provides a glimpse into recently published studies in basic, translational and clinical cancer research from MD Anderson experts. Current advances include clinical studies to investigate novel treatment strategies, a new understanding of cancer precursor lesions, identifying a calcium signaling receptor, characterizing nodal immune flair after immunotherapy, a community screening tool for BRCA testing and a new method for diagnosing Clostridioides difficile infections.
Study reveals new therapeutic target for C. difficile infection
A new study paves the way for the development of next generation therapeutics for the prevention and treatment of Clostridioides difficile infection (CDI), the most frequent cause of healthcare-acquired gastrointestinal infections and death in developed countries.
Study on Green Kiwifruit to Treat Chronic Constipation and New ACG Clinical Guidelines on C. difficile Infection Featured in the June Issue of The American Journal of Gastroenterology
The June issue of AJG includes articles on the effectiveness of OTC therapies and green kiwifruit as a dietary therapy for chronic constipation, as well as new ACG Guidelines on the Prevention, Diagnosis, and Treatment of C. difficile infections, and more.
Inflamed Environment Is C. diff Paradise
A new study shows that the inflammation caused by Clostridioides difficile (C. diff) infection gives the pathogen a two-fold advantage: by both creating an inhospitable environment for competing bacteria and providing nutrients that enable C. diff to thrive.
Study: Diet Makes a Difference in Fight Against Hospital-Acquired Infection
Popular diets low in carbs and high in fat and protein might be good for the waistline, but a new UNLV study shows that just the opposite may help to alleviate the hospital-acquired infection Clostridioides difficile. The results appeared in a study published Feb. 11 in mSystems, an open access journal of the American Society for Microbiology.
Researchers Identify Key Structure of C. Difficle Bacteria That Could Lead to Future Treatments
– Researchers from the University of Maryland School of Medicine and their colleagues have identified the structure of the most lethal toxin produced by certain strains of Clostridium difficile bacteria, a potentially deadly infection associated with the use of antibiotics. The researchers mapped out the delivery and binding components of the toxin, which could pave the way for new drugs to neutralize it.