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UrduRegulatory T cells (Tregs) are protective in atherosclerosis but numbers are reduced during disease progression due to cell death and loss of stability. Oxidized lipids are abundant in atherosclerotic lesions and can activate innate immune cells, but there is limited…
Tag: Regulatory T Cells
CHOP-led Study Identifies Two Different Regulatory T Cell Populations
A regulatory class of human T cells descends from two different origins, one that relates to autoimmunity and one that relates to protective immunity, according to a new study led by Children’s Hospital of Philadelphia (CHOP). The findings, published today in Science Immunology, could pave the way for new treatments for autoimmune diseases that target the immune system selectively.
Haywire T cells attack protein in “bad” cholesterol
Detecting these T cells may lead to diagnostics to better detect heart disease—and disease severity.
C is for Vitamin C—a key ingredient for immune cell function
Regulatory T cells (Tregs) help control inflammation and autoimmunity in the body. Unfortunately, it has proven difficult to find the right molecular ingredients to induce stable iTregs. A new study reports that Vitamin C and TET proteins can work together to give Tregs their life-saving power.
UCI-led study finds unleashing certain T cells may lead to new treatments for multiple sclerosis
In a new University of California, Irvine-led study, researchers found that a certain protein prevented regulatory T cells (Tregs) from effectively doing their job in controlling the damaging effects of inflammation in a model of multiple sclerosis (MS), a devastating autoimmune disease of the nervous system.
Regulatory T cells could lead to new immunotherapies aimed at treating multiple sclerosis
In a new University of California, Irvine-led study, researchers have discovered how regulatory T cells (Treg) are instrumental in limiting the damage caused to the spinal cord in diseases like multiple sclerosis (MS).
T cells can shift from helping to harming in atherosclerosis
At La Jolla Institute for Immunology (LJI) researchers are dedicated to finding a way to stop plaques from forming in the first place. In a new study, LJI scientists show that certain T lymphocytes, a type of white blood cell, that start out trying to fight the disease can end up increasing inflammation and making atherosclerosis cases even worse.
Moffitt Researchers Find Dual Inhibitor May Be Safer for Chronic Lymphocytic Leukemia Patients
Moffitt Cancer Center researchers want to learn more about how PI3K inhibitor therapy works with the body’s immune system to determine if there are ways to predict or mitigate associated adverse effects. Their findings were published in the July 14 issue of Blood Advances, a journal of the American Society of Hematology.