English
Arabic
Chinese (Simplified)
Dutch
Esperanto
French
German
Greek
Italian
Japanese
Korean
Portuguese
Russian
Spanish
UrduCryoprotectants are used to protect biological material during frozen storage They have to be removed when defrosting, and how much to use and how exactly they inhibit ice recrystallisation is poorly understood The polymer poly(vinyl)alcohol (PVA) is arguably the most…
Tag: Transplantation
Unmarried people given less intensive treatment for mantle cell lymphoma
Mantle cell lymphoma is a malignant disease in which intensive treatment can prolong life. In a new study, scientists from Uppsala University and other Swedish universities show that people with mantle cell lymphoma who were unmarried, and those who had…
A computational guide to lead cells down desired differentiation paths
A novel computer-guided design tool predicts combinations of transcription factors for more effective engineering of cell types with potential use in cell therapies and tissue modeling
3D printing materials for printing aorta model to study optimal CT scanning protocols
This article by Dr. Zhonghua Sun et al. is published in Current Medical Imaging, 2021
Life’s rich pattern: Researchers use sound to shape the future of printing
Researchers in the UK have developed a way to coax microscopic particles and droplets into precise patterns by harnessing the power of sound in air. The implications for printing, especially in the fields of medicine and electronics, are far-reaching.
Patients with Sickle Cell–Related Kidney Failure Benefit from Transplants But Are Less Likely to Receive Them
• Patients with kidney failure associated with sickle cell disease benefit from kidney transplants, but they’re less likely than other patients to receive them.
Potential biomarker predicts the risk of kidney transplant rejection in patients
Scientists have found that comparing the ratio of two immune molecules helped predict the likelihood of transplant rejection in 339 patients who received kidney transplants, the only curative treatment for late-stage kidney failure. Their results suggest that monitoring this ratio…
Transplant patients may not need steroid treatment in the long run
University of Cincinnati transplant researcher says trial confirms a regimen used at UC for years
Blood test for kidney rejection suggests new way to treat post-transplant patients
PITTSBURGH, Feb. 24, 2021 – Researchers at the University of Pittsburgh School of Medicine have discovered a blood biomarker that predicts kidney transplant rejection with a lead time of about eight months, which could give doctors an opportunity to intervene…
Scientists launch a pre-emptive strike on deadly post-transplant infection
A potential new treatment to protect immunosuppressed patients from human cytomegalovirus (HCMV) has been discovered by scientists at the University of Cambridge. Their study shows that certain epigenetic inhibitors expose and help to destroy dormant HCMV infections, which often reactivate…
Lab-grown ‘mini-bile ducts’ used to repair human livers in regenerative medicine first
Scientists have used a technique to grow bile duct organoids – often referred to as ‘mini-organs’ – in the lab and shown that these can be used to repair damaged human livers. This is the first time that the technique…
A recipe for regenerating bioengineered hair
Researchers at the RIKEN Center for Biosystems Dynamics Research in Japan have discovered a recipe for continuous cyclical regeneration of cultured hair follicles from hair follicle stem cells.
Researchers explore how to protect gut integrity to improve outcomes in blood cancers
Cancer researchers at MUSC Hollings Cancer Center discovered that a single strain of Bacteroides fragilis significantly reduced graft-versus-host disease by protecting gut integrity
Stretching possibilities
UVA researcher imagines super rubber, and has a strategy to make it
Fecal microbiota transplants help patients with advanced melanoma respond to immunotherapy
For patients with cancers that do not respond to immunotherapy drugs, adjusting the composition of microorganisms in the intestines–known as the gut microbiome–through the use of stool, or fecal, transplants may help some of these individuals respond to the immunotherapy…
Why it is harder for Brazilians of African descent to find bone marrow donors
According to a study published in Frontiers in Immunology, the reason is their genetic heterogeneity and lack of proportional representation in the Brazilian bone marrow bank
When is dead really dead?
The death prediction and physiology after removal of therapy study (DePPaRT study)
Harvard spin-off CELLVIE closes $5M seed round for therapeutic mitochondria transfer
$5M financing round led by Kizoo Technology Capital Fresh capital to be employed for productization, to prepare a clinical trial in organ transplantation and to expand cellvie’s pipeline into rejuvenation therapies Promising initial clinical data generated at Boston Children’s Hospital…
Non-Hispanic Black patients are disproportionately left off liver transplant waitlists
Insurance access, travel distance, and lack of awareness of options contribute to transplant waitlist disparities, according to new Journal of the American College of Surgeons study findings
Frailty is a factor in higher mortality for women awaiting liver transplants
More exercise, more protein may narrow the gender gap, researchers say
Too much of a good thing – persistent IFNγ depletes progenitor blood cells via BST2
When a person has an infection, the body activates immune responses to fight it. IFNγ is an inflammatory molecule produced by the immune system that helps fight infections. However, long-term exposure to IFNγ has undesirable consequences – it irreversibly exhausts…
Liquid bandage detects tissue oxygenation without the drawbacks of wired oximeters
A paint-on, transparent bandage reads the amount of oxygen reaching transplanted tissue, a crucial measure of the tissue’s viability. The new technology greatly improves on existing methods of detecting oxygen supply.
Virtual kidney transplant evaluation allows patients to be evaluated for transplantation from home
A virtual telehealth platform is allowing a surgery program to evaluate and wait-list patients for kidney transplantation.
Virtual kidney transplant evaluation allows patients to be evaluated from home
Because of the program, the Medical University of South Carolina division of transplant surgery has been able to maintain access to critical surgery at the same level as before onset of the virus
Finding a personalized approach to treating chronic rejection after lung transplantation
ANN ARBOR, Mich. – Two new papers examine the processes of lung scarring and chronic rejection of the organ after transplantation, and potential therapies to stop the graft, or transplanted organ and its tissue, from failing. “Chronic graft failure due…
UMD paves the way for growing human organs for transplantation with new proof-of-concept
Start-up company, Renovate Bioscience Inc., wins Invention of the Year and Inventor Pitch Award for this work at UMD
Do tumors stiff-arm the immune system?
An old dog with new tricks
Too many donor kidneys are discarded in U.S. before transplantation
Kidneys discarded as low-quality in U.S are similar to kidneys transplanted with acceptable outcomes in France, study finds
One-year kidney allograft outcomes do not differ by hepatitis C status of donor
Study published in the American Journal of Kidney Diseases (AJKD) shows that kidney allograft outcomes one year post-transplantation in hepatitis C virus (HCV)-negative recipients do not differ by the HCV status of the donor. Transplant centers are increasingly willing to…
FEFU scientists suggest using neuromodulation to treat patients with spinal cord injuries
Scientists from Far Eastern Federal University (FEFU) together with leading international experts suggest reconsidering the existing treatment protocol for severe spasticity, one of the main complications after spinal cord injury with partial spinal cord disruption. Spasticity aggravates a patient’s state…
COVID-19 found in the cornea: Are transplants a transmission risk?
A multi-institutional study finds that COVID-19 can be found in post-mortem corneal tissue, highlighting the importance of the donor screening process
Variation by states in heart transplant outcomes
What The Study Did: Data from the United Network for Organ Sharing database were used to examine variation at the state level in waitlist and transplant outcomes among patients listed for heart transplantation from 2011 to 2016. Authors: Alexandros Briasoulis,…
UBCO researchers suggest stool transplants can battle serious infections
Genetic analysis helps ensure successful fecal microbiota transplants
GlycoNet start-up receives up to $4 million US investment to advance regenerative medicine
Canadian biotech PanTHERA CryoSolutions is revolutionizing the cryopreservation of cells, tissues and organs for human and veterinary therapies
Synthetic biology and machine learning speed the creation of lab-grown livers
PITTSBURGH, Dec. 7, 2020 – Researchers at the University of Pittsburgh School of Medicine have combined synthetic biology with a machine-learning algorithm to create human liver organoids with blood- and bile-handling systems. When implanted into mice with failing livers, the…
Findings about cilia on cells of the vessel wall may be relevant for diabetes treatment
A new study from Karolinska Institutet and the Helmholtz Diabetes Research Center shows that primary cilia, hair-like protrusions on endothelial cells inside vessels, play an important role in the blood supply and delivery of glucose to the insulin-producing beta cells…
To Increase Organs Available for Transplantation, Reassess Organ Procurement Organizations’ Metrics
In a new paper, published in JAMA Surgery, researchers found the metrics used to rank organ procurement organizations don’t create an even playing field for organizations, and lead to inaccuracies.
To increase organs available for transplant, reassess organ procurement organizations’ metrics
ANN ARBOR, Mich. – Organ procurement organizations are a critical component in organ transplantation in the United States. But, what makes an organ procurement organization high performing and obtaining much needed organs to those awaiting a transplantation? In a new…
Why long-suffering hosts grow a thick skin
Researchers from the University of Tsukuba have shown that the sclerodermatous skin changes seen in chronic graft-versus-host disease are mediated by transforming growth factor-β1 produced by apoptotic keratinocytes stimulated by interferon-γ
Normothermic Machine Perfusion (NMP) in rat livers extended from 6 to 24 hours
In a paper published in TECHNOLOGY , a team of researchers from Massachusetts General Hospital (MGH) have demonstrated 24-hour rat liver viability in a normothermic machine perfusion (NMP) system. Rat liver perfusion is an efficient and cost-effective method to study…
Does the New Heart Transplant Allocation Policy Encourage Gaming by Providers?
A new national policy was created to make determining who receives a heart transplant more fair. But new data shows it changed some practice patterns, too.
USRDS releases 2020 Interactive Annual Data Report
The Chronic Disease Research Group ( CDRG ), in partnership with the National Institute of Diabetes and Digestive and Kidney Diseases ( NIDDK ), is proud to announce the next evolution of the United States Renal Data System ( USRDS…
Organoids produce embryonic heart
There was a time when the idea of growing organs in the lab was the stuff of science fiction. Today, stem cell biology and tissue engineering are turning fiction into reality with the advent of organoids: tiny lab-grown tissues and…
Scientists speed up artificial organoid growth and selection
Speeding up artificial organoid growth, selection
New artificial skin functions like natural skin
Researchers at the RIKEN Center for Biosystems Dynamics Research (BDR) have developed an improved human-skin equivalent that reproduces traction-force balance in the lateral direction, a property that controls the structure and physiological function of skin. This artificial skin will enhance…
SMART researchers develop new gelatin microcarrier for cell production
Gelatin-based microcarriers offer higher yield and scalability compared to existing commercial microcarriers
National campaign to capture stories of hope and transformation through living donation
The Transplant Research and Education Center (TREC) and the Terasaki Institute for Biomedical Innovation, with support from Thermo Fisher Scientific, announce the kickoff of a campaign to capture stories of hope and transformation
Lab-grown mini-lungs mimic the real thing – right down to covid infection
Living human lung air sacs in tiny dishes promise to accelerate covid research
UVA’s David S. Wilkes elected to prestigious National Academy of Medicine
David S. Wilkes, MD, dean of the University of Virginia School of Medicine, has been elected to the National Academy of Medicine, one of the highest honors in the fields of health and medicine. Wilkes was among 100 new members…
Boron nitride nanofilms for protection from bacterial and fungal infections
NUST MISIS material scientists have presented antibacterial nano-coatings based on boron nitride, which are highly effective against microbial pathogens (up to 99.99%). They can become a safe alternative to the usual antibiotics in implantology since they do not have typical…