St. Jude Children’s Research Hospital scientists have revealed a previously unknown role for CTCF, a pivotal transcription regulator linked to cancer.
Liver failure – often due to acetaminophen overdose – is fatal in 80% of cases. The labs of Profs. Ido Amit and Eran Elinav discovered three liver-cell subsets that contribute to disease progression, and found that depleting the microbiome acts on those subsets to reduce liver damage and increase survival rates. The research may lead to treatments for liver failure.
Children with aggressive blood cancers have differences — not just in the DNA code of their blood cells — but also in the heavily twisted protein superstructure that controls access to genes.