Study: Blood stem cell diversity arises in embryonic development

All humans have a diverse set of blood stem cell types that help govern overall health. As people age, they tend to lose this diversity, increasing their risk for blood cancers, cardiovascular disease and all-causes death. Yale School of Medicine…

See-through zebrafish, new imaging method put blood stem cells in high-resolution spotlight

MADISON — For the first time, researchers can get a high-resolution view of single blood stem cells thanks to a little help from microscopy and zebrafish.Researchers at the University of Wisconsin–Madison and the University of California San Diego have developed a method for scientists to track a single blood stem cell in a live organism and then describe the ultrastructure, or architecture, of that same cell using electron microscopy.

Six patients with rare blood disease are doing well after gene therapy clinical trial

UCLA researchers are part of an international team that reported the use of a stem cell gene therapy to treat nine people with the rare, inherited blood disease known as X-linked chronic granulomatous disease, or X-CGD. Six of those patients are now in remission and have stopped other treatments. Before now, people with X-CGD – which causes recurrent infections, prolonged hospitalizations for treatment, and a shortened lifespan – had to rely on bone marrow donations for a chance at remission.