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UrduMSU researchers now can identify more proteins, or biomarkers, in blood plasma, including those linked to specific diseases like cancer. By identifying these biomarkers earlier, medical researchers can create better diagnostic tests and drugs that target diseases sooner, improving patient outcomes.
Tag: biomarkers
Setting New Research Vision for Cedars-Sinai Guerin Children’s
Cedars-Sinai Guerin Children’s is building a formidable pediatric research enterprise aimed at identifying the genetic underpinnings of childhood diseases and developing novel therapies.
People with schizophrenia show distinct brain activity when faced with conflicting information
In a study published November 7 in the journal Cell Reports Medicine, researchers from Tufts University School of Medicine and Vanderbilt University School of Medicine show that people with schizophrenia generate distinct neural patterns when asked to make decisions based on conflicting information. The work offers one of the first biological tests to assess whether someone is prone to inflexible thinking and, by monitoring changes in these patterns, a new way to measure whether treatments are working.
Additional research highlights from the 2024 ASTRO Annual Meeting
In addition to the studies featured on the press program (details here) for the 2024 American Society for Radiation Oncology (ASTRO) Annual Meeting, the following studies were recommended by ASTRO experts and may be of interest to journalists.
MD Anderson Research Highlights for September 19, 2024
The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back.
International Lung Cancer Experts Seek Public Comments on Updated Molecular Testing Guideline to Improve Patient Selection and Targeted Therapies
The College of American Pathologists (CAP), the International Association for the Study of Lung Cancer (IASLC), and the Association for Molecular Pathology (AMP) announced today the open comment period for the revised 2018 evidence-based guideline, “Updated Molecular Testing Guideline for the Selection of Lung Cancer Patients for Treatment With Targeted Tyrosine Kinase Inhibitors.”
MD Anderson Research Highlights for May 21, 2024
The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back.
Intense Ultrasound Extracts Genetic Info for Less Invasive Cancer Biopsies #ASA186
At the University of Alberta, researchers explored how intense ultrasound can release biological indicators of disease from cells. These biomarkers can help identify different types of cancer and inform the subsequent therapy.
Study finds biomarkers for psychiatric symptoms in patients with rare genetic condition 22q
A new UC Davis study finds biomarkers that could identify patients with 22q11.2 deletion syndrome who are more likely to develop schizophrenia.
New Frontiers in Treating GI Cancers
Gastrointestinal cancers were once diagnosed primarily by location. A tumor in the liver was liver cancer, while one in the pancreas was pancreatic. The few chemotherapy treatments available affected the entire patient—sometimes causing difficult side effects.
Detecting breast cancer through a spit test
A new saliva test could provide a quick and cheap way to screen for breast cancer
High biological age may increase the risk of dementia and stroke
People who have a higher biological age than their actual chronological age have an increased risk of stroke and dementia. The findings suggest that by slowing down the body’s aging processes, it may be possible to reduce or delay the onset of disease.
NCCN Announces Research Funding for Biomarker-Directed Therapy in Metastatic Colorectal Cancer, in Collaboration with Fight CRC and Pfizer
The National Comprehensive Cancer Network (NCCN) Oncology Research Program (ORP) today announced new grants awarded to improve quality initiatives focused on optimizing biomarker-directed therapy in metastatic colorectal cancer.
MD Anderson Research Highlights for August 2, 2023
The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back.
Recent developments include a novel biomarker that may predict the aggressiveness of pancreatic cancer precursors, insights into the structure and function of a breast and ovarian cancer susceptibility gene, a new approach to overcoming treatment resistance in ovarian cancer, distinguishing features of young-onset rectal cancer, a biomarker and potential target for metastatic lung cancer, machine learning models to better predict outcomes of patients with mantle cell lymphoma (MCL), and a promising therapy for patients with relapsed/refractory MCL.
Researchers Design Multiclass Cancer Diagnostic Tool Using AI, MicroRNA
MicroRNAs, or miRNAs, regulate genes and biological processes in the human body, including cancer formation and development. To explore the feasibility of miRNAs as cancer biomarkers, researchers created a multiclass cancer diagnostic model using miRNA expression profiles. The study examined the relationship between the composition of miRNAs and various types of cancers. Findings suggest that miRNAs may be highly unique to specific cancerous tissues and can be strong biomarkers for detection and classification in both research and the clinical field
Proteins Predict Significant Step Toward Development of Diabetes
Scientists have taken an important step forward in predicting who will develop Type 1 diabetes months before symptoms appear.
UCSF Internal Medicine Specialist to be Celebrated for Diabetes Epidemiology Research
Alka M. Kanaya, MD, UC San Francisco primary care physician and researcher, is being recognized with the 2023 Kelly West Award for Outstanding Achievement in Epidemiology from the American Diabetes Association (ADA). The award recognizes significant contributions to the field of diabetes epidemiology.
MD Anderson Research Highlights for June 7, 2023
The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention.
Why Do Some Long Covid Patients Continue to Have Difficulty Exercising?
In a study published in the Journal of Infectious Diseases, a team of researchers from UC San Francisco found that lower than expected exercise capacity was common among people with Long COVID and chronotropic incompetence (inadequate heart rate increase during exercise) was the most common reason. They also found reduced exercise capacity to be correlated with early post-Covid elevations of inflammatory biomarkers. In addition, they found that reactivation of Epstein-Barr virus (EBV) may be related to reduced heart rate while exercising.
SMU Biosciences professor receives NIH grant for research on epilepsy
An estimated 50 million people worldwide have epilepsy, making them 16 times more likely to die suddenly compared to the general population. SMU biology researcher Edward Glasscock has received a 5-year, $3 million grant from the National Institutes of Health for a study that he hopes will lead to the identification of biomarkers to help identify people at risk for sudden unexpected death in epilepsy, known as SUDEP.
MD Anderson Research Highlights for April 19, 2023
The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back.
Sugar molecule in blood can predict Alzheimer’s disease
Early diagnosis and treatment of Alzheimer’s disease requires reliable and cost-effective screening methods.
MD Anderson Research Highlights for March 29, 2023
The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention.
Link between chronic kidney disease and cardiovascular disease explained
Chronic kidney disease is linked to the formation of mineral deposits on blood vessel walls, known as “calcification”, causing cardiovascular disease.
F1 driver seat ‘avatar’ has potential to improve comfort and performance
Formula 1 team Williams Racing has partnered with University experts to develop the first-known driver seat using pioneering biomechanics technology
Three new biomarkers identified to detect consumption of emerging synthetic cannabinoid
A team of scientists from the National University of Singapore (NUS) has successfully identified the urinary biomarkers of an emerging subclass of synthetic cannabinoids, called OXIZID, to monitor potential abuse.
New biomarker could help diagnose Alzheimer’s disease early
Recent studies have led to the development of imaging and spinal fluid tests for patients with Alzheimer’s disease. However, the tests can only monitor severe disease. Reporting in ACS Chemical Neuroscience, researchers have now identified a biomarker that could help physicians diagnose AD earlier.
Burping bacteria: Identifying Arctic microbes that produce greenhouse gases
As greenhouse gases bubble up across the rapidly thawing Arctic, Sandia National Laboratories researchers are trying to identify other trace gases from soil microbes that could shed some light on what is occurring biologically in melting permafrost in the Arctic.Sandia bioengineer Chuck Smallwood and his team recently spent five days collecting lakebed soil and gas samples.
Better Sleep Linked with Higher Omega-3 Fatty Acids
IAFNS-supported global study links higher omega-3 blood levels with lower risk of excessively long sleep duration.
Smidt Heart Institute Experts to Present Innovative Research Findings at European Society of Cardiology Congress 2022
Experts from the Smidt Heart Institute at Cedars-Sinai, home to California’s top-ranked cardiology and heart surgery programs, will present an array of innovative research—including late-breaking science—during the European Society of Cardiology Congress 2022, taking place in person and virtually Aug. 26-29.
Scientists Identify Novel Molecular Biomarkers in Cells That Spread a Deadly Form of Breast Cancer
Studying a deadly type of breast cancer called triple negative, Johns Hopkins Medicine scientists say they have identified key molecular differences between cancer cells that cling to an initial tumor and those that venture off to form distant tumors.
‘iTEARS’ could help diagnose diseases by isolating biomarkers in tears
In ACS Nano, researchers report a nanomembrane system that harvests and purifies tiny blobs called exosomes from tears, allowing researchers to quickly analyze them for disease biomarkers. Dubbed iTEARS, the platform could enable more efficient and less invasive diagnoses for many diseases.
Novel Method for Early Disease Detection Using DNA Droplets
Aqueous droplet formation by liquid-liquid phase separation (or coacervation) in macromolecules is a hot topic in life sciences research.
Blood Biomarker Predicts Complicated Crohn’s Disease Years Before Diagnosis: Study
An international team led by a University of Toronto researcher has found that an antibody detectable in blood predicts severe Crohn’s disease and is detectable up to seven years prior to disease diagnosis.
New research identifies blood biomarker for predicting dementia before symptoms develop
New research from NUI Galway and Boston University has identified a blood biomarker that could help identify people with the earliest signs of dementia, even before the onset of symptoms.
UTSW-led research identifies new imaging biomarkers that predict antidepressant response
The outcome predictive models were developed in part using data from a large multi-center National Institute of Mental Health-funded study and published in the journal Biological Psychiatry. The findings provide strong evidence that the current trial-and-error approach used in clinical practice for the selection of the right antidepressant can be replaced with this new precision medicine approach.
The Brain Changes Its Rhythm Within Minutes of Therapeutic Stimulation During Deep Brain Stimulation Surgery for Treatment-Resistant Depression
Deep brain stimulation (DBS) has been demonstrated to be an effective treatment for many patients suffering with treatment-resistant depression, but exactly how it works is not known.
Cleveland Clinic Study Links Gut Microbiome and Aggressive Prostate Cancer
Cleveland Clinic researchers have shown for the first time that diet-associated molecules in the gut are associated with aggressive prostate cancer, suggesting dietary interventions may help reduce risk. Findings from the study were published in Cancer Epidemiology, Biomarkers & Prevention.
Novel Assay Finds New Mechanism Underlying Red Blood Cell Aging
A multifaceted microfluidic in vitro assay is helping to identify the role of hypoxia on red blood cell aging via the biomechanical pathways. It holds promise for investigating hypoxic effects on the metastatic potential and relevant drug resistance of cancer cells.
Examining Correlation Between Occupational Noise, Heart Disease
Hearing conservation programs and policies aim to protect workers from noise-induced hearing loss, but it remains unclear whether stress reactions caused by noise exposure might also lead to other negative health outcomes. In The Journal of the Acoustical Society of America, researchers describe how data from the Canadian Health Measures Survey do not support an association between loud noise exposure and changes in biomarkers for cardiovascular disease or outcomes.
New biomarkers may detect early eye changes that can lead to diabetes-related blindness
Optometry researchers have identified new biomarkers that may advance the early detection of diabetic retinopathy, the most common diabetic eye disease and a leading cause of blindness in U.S. adults.
Spinal Fluid Biomarkers Detect Neurodegeneration, Alzheimer’s Disease in Living Patients
New research reveals that the same framework of proteins and peptides that can detect Alzheimer’s disease in cerebrospinal fluid can also detect other forms of neurodegeneration, like frontotemporal degeneration.
Wistar Scientists Discover Blood-based Biomarkers to Predict HIV Remission After Stopping Antiretroviral Therapy
New biomarkers that predict HIV remission after antiretroviral therapy (ART) interruption are critical for the development of new therapeutic strategies that can achieve infection control without ART, a condition defined as functional cure. Wistar Scientists have identified metabolic and glycomic signatures in the blood of a rare population of HIV-infected individuals who can naturally sustain viral suppression after ART cessation, known as post-treatment controllers. T
Memory Biomarkers Confirm Aerobic Exercise Helps Cognitive Function in Older Adults
Until now, systemic biomarkers to measure exercise effects on brain function and that link to relevant metabolic responses were lacking. A study shows a memory biomarker, myokine Cathepsin B (CTSB), increased in older adults following a 26-week structured aerobic exercise training. The positive association between CTSB and cognition, and the substantial modulation of lipid metabolites implicated in dementia, support the beneficial effects of exercise training on brain function and brain health in asymptomatic individuals at risk for Alzheimer’s.
Research News Tip Sheet: Story Ideas from Johns Hopkins Medicine
During the COVID-19 pandemic, Johns Hopkins Medicine Media Relations is focused on disseminating current, accurate and useful information to the public via the media. As part of that effort, we are distributing our “COVID-19 Tip Sheet: Story Ideas from Johns Hopkins” every other Wednesday.
Drug-Induced Liver Injury, Translational microRNA Biomarkers, and More Featured in January 2021 Toxicological Sciences
in the January 2021 issue, Toxicological Sciences offers an engaging slate of research in toxicology, from endocrine toxicology and biomarkers to genetic and epigenetic toxicology and mixtures toxicology.
Researchers Help Pioneer New Era in Prostate Cancer Active Surveillance
Sylvester Comprehensive Cancer Center researchers are looking at ways to combine imaging and biomarkers to predict prostate cancer progression more accurately.
Dopamine Surge Reveals How Even for Mice, ‘There’s No Place Like Home’
“There’s no place like home,” has its roots deep in the brain. Using fiber photometry, scientists are the first to show that home evokes a surge of dopamine in mice that mimics the response to a dose of cocaine. The study demonstrates how dopamine rises rapidly in mice moved from a simple recording chamber to their home cage, but less so when they return to a cage not quite like the one they knew.
Ovarian Cancer Screening Study Focuses on Early Detection in Women at Low Risk
Atlantic Health System is enrolling women in a landmark study that uses a simple blood test for the CA-125 protein to screen women who are at low risk for ovarian cancer. The purpose of the clinical trial is to help determine whether this test can catch ovarian cancer early in women who would not normally be screened for it. Atlantic Health System hospitals are the only centers in the New York metro region to participate in the study, and have the third highest enrollment numbers in the nation.
Ingo Mellinghoff Named Chair of MSK’s Department of Neurology
Neuro-oncologist and renowned physician-scientist Ingo Mellinghoff will lead MSK’s distinguished Department of Neurology after previously serving as Acting Co-Chair.