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UrduResearchers seeking to improve the use of radium-223 to target cancer cells investigated how the isotope interacts with two chelators, macropa and DOTA. Experiments and computer-driven models discovered that macropa is the strongest chelator for binding radium identified so far.
Tag: Treatment
Expert Addresses Stigma, Disparities in Prostate Cancer
David M. Golombos, MD, addresses prostate cancer topics
Dr. Charles Park and Dr. Jon McIver of The Minimally Invasive Brain and Spine Center at Mercy are Featured Guests for the September 2023 edition of “Medoscopy”
Charles C. Park, M.D., Ph.D., and Jon I. McIver, M.D., neurosurgeons with The Minimally Invasive Brain and Spine Center at Mercy, are featured guests on Mercy’s monthly talk show, “Medoscopy”, September 20th-21st at 5:30 p.m. EST.
Targeting TAK1 protein to treat systemic sclerosis
Systemic sclerosis is the scaring of multiple organs within the body resulting in difficulty in functioning for these organs. The disease can become deadly if the organ scaring isn’t treated properly. Researchers at the University of Michigan Health System have identified a protein in the disease that may be a new target for treatment.
Bringing epilepsy care closer to home may improve outcomes
Access to care affects people with epilepsy worldwide. Bringing care closer to home can help—but what about bringing care inside the home?
Among Young People, Being Around Peers May Elicit Greater Drinking Cravings than the Presence of Alcohol
The presence of peers is a key prompt for alcohol cravings among young people, according to a new study in Alcohol: Clinical & Experimental Research. When certain settings, people, or items—a bar, a friend, a glass—are paired with alcohol, they can become conditioned cues, eliciting drinking cravings. These learned reactions are associated with alcohol use disorder (AUD), treatment outcomes, and relapse. Adolescents and emerging adults are particularly susceptible to peer influence. In real-world settings, studies have found that the presence of peers predicts young people’s intensifying drinking cravings at the moment. In laboratory studies, however, peer influence is largely absent, potentially limiting the usefulness of their findings. Better understanding peers as alcohol cues could inform more effective AUD prevention and treatment programs. For the current study, researchers from Brown University, RI, evaluated alcohol cravings among youth in the human laboratory, using drinking-
AI Tool Predicts Colon Cancer Survival, Treatment Response
New AI tool accurately predicts both overall survival and disease-free survival after colorectal cancer diagnosis.
The model uses visual markers on pathology images to glean insights into a tumor’s genomic profile and predicts tumor behavior, disease progression, treatment response.
The new model could help augment clinical decision-making.
Because the AI tool relies on images alone, it could be particularly valuable for hospitals lacking the technology or expertise to perform sophisticated genomic profiling of tumor tissues.
Prompt Treatment for Functional Neurological Disorder in Children Is Highly Effective
Treatment is scarce for functional neurological disorder (FND), which requires a multidisciplinary approach. A special report published in the March/April issue of Harvard Review of Psychiatry (HRP) aims to show clinicians and institutions around the world what is needed to establish effective community treatment programs for FND, as well as hospital inpatient and outpatient interventions, in their own health care settings. HRP is published in the Lippincott portfolio by Wolters Kluwer.
Chula’s AICute Innovation – An Assessment Tool for Ischemic Stroke Risk to Reduce Disability and Death
A research team from the Faculty of Medicine and Faculty of Engineering, Chulalongkorn University has jointly developed AICute, an innovative program to assess the chances of stroke caused by heart disease (Ischemic Stroke), aimed at helping hospitals that lack cardiologists to enhance the effectiveness of stroke treatment, reduce congestion in hospitals and medical schools.
Improved Accuracy of Screening Tools for Fetal Alcohol Spectrum Disorder May Lead to Faster Diagnosis and More Timely Intervention
A new screening instrument has the potential to more accurately identify fetal alcohol spectrum disorder (FASD), reducing missed and erroneous diagnoses in affected children and facilitating treatment and support, a new study suggests. Prenatal alcohol exposure (PAE) is a known cause of birth and growth defects and neurobehavioral issues.
Eartest by Eartone Application Detects Dementia Risk by Checking the Hearing of Words in Thai language
The Faculties of Medicine and Science, Chulalongkorn University, in collaboration with University College London (UCL), the United Kingdom, together with industrial partner have developed Eartest by Eartone Application that examines hearing with Thai words processing that the public can use to screen dementia by themselves before consulting physicians to help prevent and reduce future risk of dementia.
UChicago Medicine first in state to offer novel super-saturated oxygen therapy to patients with ‘widowmaker’ heart attacks
The treatment is the first therapy to mitigate heart muscle damage after catheter-based intervention and could increase long-term survival for heart attack patients.
New Guideline Introduces Recommendations for Integrative Approach to RA Treatment
The American College of Rheumatology (ACR) released a summary of its new guideline for Exercise, Rehabilitation, Diet and Additional Integrative Interventions for Rheumatoid Arthritis. This is the first ACR guideline about an Integrative Approach to RA.
Few children affected by monkeypox so far – But risks are higher in children 8 or younger
Children aged 8 years or younger should be considered a group at high risk for more severe monkeypox disease, reports The Pediatric Infectious Disease Journal, the official journal of The European Society for Pediatric Infectious Diseases. The journal is published in the Lippincott portfolio by Wolters Kluwer.
UCLA researchers identify model for studying treatments targeting MS progression
This model can be used by researchers to discover targets for treatments that improve walking, cognitive, coordination and visual disabilities in MS.
Which student-athletes can be safely released to an athletic trainer after concussion?
When a high school or college student consults a physician about a sport-related concussion, their age, severity of symptoms, number of previous concussions, and family history of psychiatric disorders predict whether they can be released to supervision by an athletic trainer or will need additional medical care, according to an article in the Clinical Journal of Sports Medicine. The journal is published in the Lippincott portfolio by Wolters Kluwer.
Updated Guideline Introduces Recommendations for Prevention and Treatment of Glucocorticoid-Induced Osteoporosis
The American College of Rheumatology (ACR) released a summary of its updated guideline for the Prevention and Treatment of Glucocorticoid-Induced Osteoporosis. New osteoporosis medications and new literature have become available since the last ACR treatment guideline was published in 2017.
Researchers discover potential treatment for Chagas disease
Researchers from the University of Georgia have discovered a potential treatment for Chagas disease, marking the first medication with promise to successfully and safely target the parasitic infection in more than 50 years. Human clinical trials of the drug, an antiparasitic compound known as AN15368, will hopefully begin in the next few years.
Mood Influences Alcohol Craving Differently in Men and Women, Pointing the Way to Alcohol Use Disorder Treatments Tailored by Sex
Drinkers’ mood shifts and exposure to alcohol-related cues — beer cans, bars, and drinking buddies — contribute to alcohol cravings in opposite ways for men and women, a new study suggests. The findings have implications for how men and women develop dangerous drinking habits and ways that this might be prevented or treated. Various theories link alcohol use to positive and negative emotions: drinking to either enhance good mood or cope with stress, potentially becoming a self-reinforcing cycle. Studies have yielded mixed findings, however, suggesting that mood interacts with subconscious cognitive processes to prompt alcohol-seeking.
Mangosteen Peel as Medicine – CU’s Faculty of Veterinary Science is Successful in Replicating Mangosteen Peel Extract! Treatment for Intestinal Inflammation in Humans and Animals
The Faculty of Veterinary Science, Chulalongkorn University has researched and replicated “hydroxy-xanthones”, the vital extracts rich in antioxidants found in mangosteen peels that kill germs and halt infections in the intestinal mucosa. It hopes to expand to include health products for humans and animals in the future.
Artificial Intelligence Edges Closer to the Clinic
TransMED analyzes patient data from similar diseases across multiple sources to understand COVID-19 patient outcome risk factors.
FINDING THE RIGHT TREATMENTS FOR GENETIC HAIR LOSS
Hereditary hair loss, also known as androgenetic alopecia or pattern hair loss, is the most common form of hair loss in both men and women, affecting millions of people worldwide.
DMIND Application for Screening Depression – An AI Innovation from CU Faculties of Medicine and Engineering Researchers
Introducing a new dimension for consultations with those suffering from depression by the Department of Mental Health and the DMIND AI Innovation from Chula’s Faculties of Medicine and Engineering that provides screening for depression through the Mor Prom Application with greater accuracy, accessibility, and convenience thus reducing the burdens on medical practitioners and psychologists in taking care of patients with depression.
First Mutation-Targeted Bladder Cancer Drug May Be Under-Used
The first bladder cancer drug targeting a cancer-driving gene mutation has been used relatively little despite its clear efficacy in a clinical trial, suggests a JAMA Oncology study led by the University of Pennsylvania. Researchers analyzed a large, nationwide database of cancer cases and found that bladder cancer patients potentially eligible for erdafitinib (Balversa) treatment, fewer than half had a record of being tested for the relevant gene mutation. Of those who were tested and found to have the mutation, fewer than half received the treatment.
CU Innovation Center for Veterinary Clinical Training Provides Simulated Training to Hone Students’ Skills before They Give Real Treatment
Chula opens a state-of-the-art innovation center for veterinary students to practice their clinical skills with a simulated and modern lab classroom to hone students’ skills and develop their expertise and a space for international training to promote veterinary and medical education.
Study Finds Treat-to-Target ULT Strategy Manages Gout Effectively and Safely with No Cardiovascular Toxicity
New research presented this week at ACR Convergence, the American College of Rheumatology’s annual meeting, shows that allopurinol and febuxostat may effectively lower urate levels when used in a treat-to-target approach. Importantly, both urate-lowering therapies were very effective with 90% of patients reaching target urate levels. Additionally, both appeared safe, with no evidence of increased cardiovascular toxicity.
IU study illustrates the need to treat smoking and mental health problems together
IU study illustrates the need to treat mental health problems and smoking together.
Stress-relief Music Therapy Can Also Effectively Relieve Pain
Medical results show that music therapy can lower blood pressure, relieve pain during chemotherapy and dialysis, as well as stimulate the elderly brain. The Faculty of Fine and Applied Arts, Chulalongkorn University is offering a Music Therapy Program aiming to heal the ever-increasing patients with various chronic diseases in society.
Researchers explore promising treatment for MRSA ‘superbug’
A new Cornell study has found the antimicrobial properties of certain stem cell proteins could offer a potential treatment to reduce infection in skin wounds.
Innovative techniques help treat boy’s rare condition
Several innovative, minimally invasive techniques used over the past 12 months to improve Carter’s health — including a first-of-its-kind procedure performed in the United States — means he can finally go home.
Researchers speed identification of DNA regions that regulate gene expression
St. Jude Children’s Research Hospital scientists have developed a highly efficient method to address a major challenge in biology—identifying the genetic ‘switches’ that regulate gene expression.
Chula Unveils World-Class Innovative Prosthesis Made by Thais
April 9, 2021 – Chula holds the 4th CHULA the Impact Seminar entitled “World–Class Innovative Prosthesis Made by Thais” showcasing the capabilities of Chula researchers from Chula Engineering Enterprises
Three-Drug Therapy for Most Common Genetic Cause of Cystic Fibrosis Found Safe and Effective in 6-11-Year-Olds
An international, open-label Phase 3 study, co-led by Susanna McColley, MD, from Ann & Robert H. Lurie Children’s Hospital of Chicago, found that a regimen of three drugs (elexacaftor/tezacaftor/ivacaftor) that targets the genetic cause of cystic fibrosis was safe and effective in 6-11-year-olds with at least one copy of F508del mutation in the CFTR gene, which is estimated to represent almost 90 percent of the cystic fibrosis population in the United States.
Chula Develops a Proven Formula to Combat Hair Loss and Baldness from Mangrove Trees
Chula’s Faculty of Pharmaceutical Science has developed its very own “Mangrove–Tree (Samae–Talay) extract treatment for hair loss and baldness problem” which received the Innovation Award 2021 in Chemical Science and Pharmacy (Very Good Level) from the National Research Council of Thailand (NRCT), and is expected to hit the market this year.
Peginterferon-lambda shows strong antiviral action to accelerate clearance of COVID-19
A clinical study led by Dr. Jordan Feld, a liver specialist at Toronto Centre for Liver Disease, University Health Network (UHN), showed an experimental antiviral drug can significantly speed up recovery for COVID-19 outpatients – patients who do not need to be hospitalized. This could become an important intervention to treat infected patients and help curb community spread, while COVID-19 vaccines are rolled out this year.
New immunotherapy combination shows great promise for lung cancer, McMaster researchers find
Researchers at Canada’s McMaster University have established in lab settings that a novel combination of two forms of immunotherapy can be highly effective for treating lung cancer, which causes more deaths than any other form of cancer.
Potential New Therapies for Alzheimer’s Disease are Revealed through Network Modeling of Its Complex Molecular Interactions
Researchers from Mount Sinai and the National Center for Geriatrics and Gerontology in Japan have identified new molecular mechanisms driving late-onset Alzheimer’s Disease.
Smartphone Use Offers Tool to Treat MS, Other Diseases
Monitoring how patients with multiple sclerosis or other degenerative diseases use their smartphones could provide valuable information to help get them better treatment. In the journal Chaos, researchers used an app to record the keystroke dynamics of a control group and those of subjects in various stages of MS treatment. In doing so, they observed changes in the way people with MS typed that were not seen in subjects who did not have the disease.
ACTG Presents Data Showing Minimal Monitoring Approach to Hepatitis C Treatment is Safe and Successful at AASLD’s 2020 Liver Meeting
Study finds that in a diverse, global patient population, a minimal monitoring (MINMON) approach to hepatitis C treatment was safe and achieved comparable sustained virologic response (SVR) to current standard of care.
Stronger treatments could cure Chagas disease
Researchers have found that a more intensive, less frequent drug regimen with currently available therapeutics could cure the infection that causes Chagas disease
2020 Dickson Prize in Medicine Awarded to Pioneer Researcher in Synthetic Biology
James J. Collins, Ph.D., an innovator in synthetic biology whose ideas have contributed to novel diagnostics and treatments targeting infections and complex diseases, has been awarded the 2020 Dickson Prize in Medicine, the University of Pittsburgh School of Medicine’s highest honor.
Mount Sinai Researchers Discover Treatment Option for Rare Genetic Disorder
Researchers from the Icahn School of Medicine used a novel genetic sequencing technology to identify the genetic cause of—and a treatment for—a previously unknown severe auto inflammatory syndrome affecting an 18-year-old girl since infancy.
Researchers Identify Distinct Subtypes of Polycystic Ovary Syndrome With Novel Genetic Associations
Mount Sinai researchers have for the first time identified reproductive and metabolic subtypes of polycystic ovary syndrome (PCOS) that are associated with novel gene regions.
FDA Approves First At-Home Saliva Collection Test for Coronavirus
Rutgers’ RUCDR Infinite Biologics received an amended emergency use authorization from the FDA late Thursday for the first SARS-CoV-2 coronavirus test that will allow people to collect their own saliva at home and send to a lab for results. The decision follows the FDA’s recent emergency approval to RUCDR Infinite Biologics for the first saliva-based test, which involves health care workers collecting saliva from individuals at testing sites.
Supportive Oncodermatology Interventions Improve Patient Quality of Life
A recent survey from the GW Cancer Center found that enrollment in a supportive oncodermatology program is associated with a significantly improved quality of life score. The results are published in the Journal of Drugs in Dermatology.
University of Miami Health System to Offer Convalescent Plasma with COVID-19 Antibodies for Seriously Ill Patients
A new initiative by infectious disease experts and researchers with the University of Miami Health System offers convalescent plasma with COVID-19 antibodies as a treatment for patients who are seriously ill from the coronavirus infection or at serious risk of…
Potential new HIV treatment could mean once-a-year injection
The advance has the potential to eliminate complications that arise from missing doses of life-saving medicines, according to the study published today in Nature Materials, a leading peer-reviewed biomedical research journal.
Mount Sinai Researchers Collaborate with GenScript to Develop a COVID-19 Antibody to Treat Sick Patients
The highly targeted antibody may block the coronaviruses’ ability to enter human lung cells
Rutgers, University Hospital Lead Way in Treating COVID-19 with Convalescent Plasma from Recovered Patients
Rutgers physicians and University Hospital are leading the way in using blood plasma from patients who recovered from COVID-19 to treat new patients who are severely ill with COVID-19 infections.
Researchers use live virus to identify 30 existing drugs that could treat COVID-19
Scientists at Sanford Burnham Prebys Medical Discovery Institute, the University of Hong Kong, Scripps Research, UC San Diego School of Medicine, the Icahn School of Medicine at Mount Sinai and UCLA have identified 30 existing drugs that stop the replication of SARS-CoV-2, the virus that causes COVID-19. The study was placed on bioRxiv (pronounced “bio-Archive”), an open-access distribution service for preprints of life science research.