English
Arabic
Chinese (Simplified)
Dutch
Esperanto
French
German
Greek
Italian
Japanese
Korean
Portuguese
Russian
Spanish
UrduHi there, We are one day away from the 2024 American Heart Association Scientific Sessions. Experts from the University of Michigan Health Frankel Cardiovascular Center have several presentations, posters and discussions that cover the latest findings and innovations in the world…
Tag: Clinical Trials
November Research Tip Sheet
Cedars-Sinai has published a summary highlighting its research advances for November 2024.
How Hypoxia Helps Cancer Spread
Scientists at the Johns Hopkins Kimmel Cancer Center have identified 16 genes that breast cancer cells use to survive in the bloodstream after they’ve escaped the low-oxygen regions of a tumor. Each is a potential therapeutic target to stop cancer recurrence, and one – MUC1 – is already in clinical trials.
Researchers report first published case of a patient with treatment-emergent neuroendocrine prostate cancer who showed a remarkable response to an anti-HER2 antibody-drug conjugate
A new case report published in Annals of Internal Medicine describes the success of human epidermal growth factor receptor 2 (HER2) antibody-drug conjugate trastuzumab deruxtecan (T-DXd) in a patient with HER2-expressing treatment-emergent neuroendocrine prostate cancer (t-NEPC).
Lurie Children’s to Develop a Novel Genomic Test for More Rapid Precision Diagnosis of Brain Tumors
Ann & Robert H. Lurie Children’s Hospital of Chicago was awarded $3.7 million through the National Cancer Institute Cancer Moonshot Scholars program to advance precision diagnosis of brain tumors in children.
Lymph Node-Like Structures May Trigger the Demise of Cancer Tumors
A newly described stage of a lymph node-like structure seen in liver tumors after presurgical immunotherapy may be vital to successfully treating patients with hepatocellular carcinoma, according to a study by researchers from the Johns Hopkins Kimmel Cancer Center.
Researchers Identify Possible Treatment for Rare Disorder
Researchers at Tufts University School of Medicine and the Graduate School of Biomedical Sciences (GSBS) have identified a small molecule that, in mouse and human cell models, rectifies the underlying molecular cause of a rare genetic developmental disorder, CTNNB1 syndrome, linked with motor and intellectual disabilities and some types of autism spectrum disorder.
Mount Sinai Opens State-of-the-Art Center for Patients With Complex Conditions Including Lyme Disease and Long COVID
The Cohen Center for Recovery From Complex Chronic Illnesses will also research new therapies for these conditions
Cycling for critically ill patients improves physical function, reduces hospital stays: systematic review
A new systematic review led by researchers in Hamilton, Canada has shown that specialized in-bed cycling therapy, when used in the intensive care unit with critically ill patients, leads to better physical function and a one-day shorter length of stay in the ICU.
Bias found when drug manufacturers fund clinical trials
Psychiatric drugs are reported to be about 50% more effective in clinical trials funded by the drug’s manufacturer than when trials of the same drug are sponsored by other groups, new research shows.
New addition to standard-of-care treatments for non-small-cell lung cancer patients has potential to increase progression-free survival
Houston Methodist researchers have developed an advanced mathematical model that predicts how novel treatment combinations could significantly extend progression-free survival for patients with non-small-cell lung cancer (NSCLC), the most common type of lung cancer.
Clinical trial results show low-intensity therapy can achieve positive outcomes for certain pediatric leukemia subtypes
Using genomics and early treatment response to guide risk-stratification and low-intensity therapy use for ETV6::RUNX1 and high-hyperdiploid B-cell acute lymphoblastic leukemia benefits patients.
Histotripsy liver tumor trial successful, early clinical adoption recommended
The #HOPE4LIVER trials, testing the safety efficacy of histotripsy as a treatment for primary and metastatic liver tumors, met its goals for technical success and safety. An expert is quoted explaining the results.
MD Anderson Research Highlights Special Edition: 2024 World Conference on Lung Cancer
The University of Texas MD Anderson Cancer Center’s Research Highlights provides a glimpse into recent basic, translational and clinical cancer research from MD Anderson experts. This special edition features compelling data on lung cancer advances presented by MD Anderson researchers at the 2024 World Conference on Lung Cancer.
UC Irvine receives record $668 million in research funding for fiscal 2023-24
University of California, Irvine scholars, scientists and physicians continue to blaze new paths to help improve the world. In fiscal 2023-24, which ended June 30, UC Irvine received the most research funding in campus history: $668 million in grants and contracts.
How the scars of demolished brain tumors seed relapse
A Ludwig Cancer Research study has discovered that recurrent tumors of the aggressive brain cancer glioblastoma multiforme (GBM) grow out of the fibrous scars of malignant predecessors destroyed by interventions such as radiotherapy, surgery and immunotherapy.
Breaking the link between obesity and atrial fibrillation with a new cellular target
Blocking oxidative stress enzyme prevents, even reverses, heart condition in lab models
Mesenchymal stem cells: A promising therapeutic avenue for non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) is a pressing global health concern that is associated with metabolic syndrome and obesity. On the basis of the insights provided by Jiang et al, this editorial presents an exploration of the potent
UCLA-Led Study Unveils New Insights and Potential Treatments for Pulmonary Hypertension
A new study from researchers with UCLA Health and collaborating organizations has found that asporin, a protein encoded by the ASPN gene, plays a protective role in pulmonary arterial hypertension (PAH).
National Academies progress report: health disparities
From costing society an estimated $11 trillion to hindering new discoveries in medicine and preventing access to effective interventions, underrepresentation of women, older adults and minorities in clinical research has several significant consequences, according to recent analyses commissioned by the National Academies of Sciences, Engineering and Medicine.
FDA Approves Drug Targeting Johns Hopkins-Discovered Brain Cancer Gene Mutation
A new drug for treatment of a type of brain cancer, called IDH-mutant low-grade glioma, was approved Aug. 6 by the U.S. Food and Drug Administration (FDA). The promising new drug stems from a 2008 genetic discovery made at the Johns Hopkins Kimmel Cancer Center.
UC Irvine Institute for Clinical & Translational Science receives $28 million NIH grant
The Institute for Clinical & Translational Science at the University of California, Irvine has been awarded $28,394,693 over seven years from the National Institutes of Health as part of its Clinical & Translational Science Awards Program.
The consequences of ending abortion protection, the patient perspective on laboratory developed tests, health equity, and more to be explored at ADLM 2024
At ADLM 2024 (formerly the AACC Annual Scientific Meeting & Clinical Lab Expo) in Chicago, more than 300 experts will present cutting-edge research and technology that will shape the future of laboratory medicine and improve patient care.
Neuroscientists Discover Brain Circuits Involved in Placebo Effect for Pain Relief
Publishing in Nature, University of North Carolina School of Medicine researchers and colleagues discovered a pain control pathway that links the cingulate cortex in the front of the brain, through the pons region of the brainstem, to cerebellum in the back of the brain.
AMR Expands Clinical Research Offerings in the Carolinas with Waccamaw Dermatology Partnership
Alliance for Multispecialty Research (AMR), a leading clinical research site company, and Waccamaw Dermatology, renowned for its comprehensive, specialized dermatological care as one of the largest physician-owned and led dermatology practices in the Carolinas, today announced a strategic partnership that expands access to clinical trials in the Carolinas.
Call for Papers: Theme Issue: Artificial Intelligence in Oncology
JMIR Publications invites submissions to a new theme issue titled “Artificial Intelligence in Oncology” in its premier open access journal JMIR Bioinformatics and Biotechnology indexed in PubMed Central and PubMed, SCOPUS, Sherpa/Romeo, DOAJ and EBSCO/EBSCO Essentials.
From ‘trial and error’ to targeted precision: $17.9M grant accelerates mental health research
A major new grant will fund a study enrolling thousands of people from the time they schedule a mental health appointment, and gather data that could form the basis for precisely targeted treatment in future.
Respiratory Societies Help Bring the World Together for Bronchiectasis
In support of the third annual World Bronchiectasis Day, July 1, the Forum of International Respiratory Societies (FIRS), of which the American Thoracic Society is a founding member, is joining the COPD Foundation and several global organizations to raise awareness, share knowledge, and discuss ways to reduce the burden of bronchiectasis for patients and their families worldwide.
Wren Laboratories Unveils Dynamic Executive Leadership Team and 2024 Commercial Strategy Overhaul
Wren Laboratories announced executive leadership for commercial operations and market expansion. Dr. Abdel Halim is appointed CEO and CSO. Troy Tremaine Appointed to CCO, Dr. Eva Szarek Head of Marketing, and Melissa Ferone director of quality. Expansion includes AI-driven mRNA liquid biopsy genomic assays for biopharma and diagnostics.
Q&A: New Frontiers in ALS Research
Clive Svendsen, PhD, executive director of the Board of Governors Regenerative Medicine Institute and professor of Medicine and Biomedical Sciences at Cedars-Sinai, is developing new treatments and models for amyotrophic lateral sclerosis (ALS) using stem cells.
UC San Diego Health First in Region to Provide Novel Therapy for Melanoma
Breakthrough one-time cancer treatment option for select patients with metastatic melanoma and solid tumors now offered at UC San Diego Health.
Endocrine Society Guideline recommends healthy adults under the age of 75 take the recommended daily allowance of vitamin D
Healthy adults under the age of 75 are unlikely to benefit from taking more than the daily intake of vitamin D recommended by the Institutes of Medicine (IOM) and do not require testing for vitamin D levels, according to a new Clinical Practice Guideline issued today by the Endocrine Society.
Project Could Transform Clinical Trials for Pediatric Brain Tumors
Randomized controlled trials have long been the gold standard for evaluating new therapies. But for pediatric brain tumors, it can be difficult—if not impossible—to enroll the large numbers of patients needed for these studies.
Getting Under the Skin at May 11 Symposium on Melanoma
The Angeles Clinic and Research Institute, an affiliate of Cedars-Sinai Cancer, is teaming up with the AIM at Melanoma Foundation for the 14th year to host a free melanoma symposium for patients, caregivers and clinicians.
Wake Forest University School of Medicine Approved for $1 Million in PCORI Funding for Patient Subgroup Discovery Study
Researchers at Wake Forest University School of Medicine have been approved for a $1 million award by the Patient-Centered Outcomes Research Institute (PCORI) for a methodology study.
Alzheimer’s Drug Development Pipeline: Positive Results, New Insight Position 2024 as ‘Learning Year’
Alzheimer’s treatment studies offer hope as UNLV expert predicts new potential drugs, biomarkers will yield critical insight for future development.
Yale Cancer Center Experts, Scientists to Share Vision and Research at Leading Conference
The five-day session (April 5-10), themed as “Inspiring Science. Fueling Progress. Revolutionizing Care,” will include new findings from Yale Cancer Center researchers.
Empowering Minority Cancer Patients: Tips for Advocacy and Support
Mariam F. Eskander, MD, MPH, surgical oncologist in the Gastrointestinal Oncology Program at Rutgers Institute of New Jersey, offers insight and tips for minority individuals navigating a cancer diagnosis and how we can all work together to mitigate cancer disparities.
Therapeutic utility of human umbilical cord-derived mesenchymal stem cells-based approaches in pulmonary diseases: Recent advancements and prospects
Pulmonary diseases across all ages threaten millions of people and have emerged as one of the major public health issues worldwide. For diverse disease conditions, the currently available approaches are focused on alleviating clinical sympt
New LongCOVID research launched by PolyBio’s global consortium of scientists
PolyBio Research Foundation today announced the second phase of its LongCovid Research Consortium (LCRC), including the distribution of $15M to fund research and clinical trials.
Praedicare Leverages AI, Mathematical Models of Disease Progression and Mapping in World’s First In Silico Clinical Trial of Its Kind
The in silico trial demonstrated 2X the efficacy of the current treatment (>80% vs 39%); 3X shorter treatment time to cure (6 vs 18 months); 1 drug compared to a 3-drug combo for the standard of care; and preclinical results in shorter time than animal models.
Cedars-Sinai Introduces Dutch Health-Tech Startups to US Markets
Cedars-Sinai will host 10 Dutch health technology startups in Los Angeles to share best practices on bringing innovative ideas and products to the U.S. market.
Psychological care delivered over the phone is an effective way to combat loneliness and depression, according to a major new study
The study, led by a team based at the University of York and Hull York Medical School and at Tees, Esk and Wear Valleys NHS Foundation Trust, found levels of depression reduced significantly and the benefits were greater than those seen for antidepressants.
Clinical Trials of Sticky, Bone-Boosting Proteins Funded By Department Of Defense
A startup company, Theradaptive, founded by Hertz Fellow Luis Alvarez aims to revolutionize sports medicine, orthopedic surgery, dental implants and even cancer care through its uniquely engineered proteins.
Researchers Discover Why One Type of Chemotherapy Works Best in Bladder Cancer
Tisch Cancer Institute researchers discovered that a certain type of chemotherapy improves the immune system’s ability to fight off bladder cancer, particularly when combined with immunotherapy, according to a study published in Cell Reports Medicine in January.
Global platform study presents results to guide care of severely ill patients with COVID-19 using routinely available drugs
The world’s largest trial of multiple interventions for critically ill adults with COVID-19 has simultaneously released results about two of its treatments, vitamin C and simvastatin
Highest risk patients with clear-cell renal cell carcinoma benefit from adjuvant everolimus
New study finds everolimus benefits high-risk kidney cancer patients
Clinical trial reveals benefits of inhaled nitric oxide for patients with respiratory failure due to COVID-19 pneumonia
Inhaled nitric oxide gas widens blood vessels in the lungs and is used to treat severe cardio-pulmonary conditions in newborns and adults.
High cure rate, low toxicity maintained with shortened radiation treatment for intermediate risk prostate cancer, study finds
People with intermediate risk, localized prostate cancer can be treated as effectively using fewer and higher doses of radiation therapy delivered over five treatment sessions as they can with lower doses delivered over several weeks, a new phase III randomized trial suggests.
Tip Sheet: Personalizing cancer treatment, cancer and the LGBTQ+ community – and expanded Medicaid coverage linked to increased participation in cancer clinical trials
SEATTLE — Sept. 6, 2023 — Below are summaries of recent Fred Hutchinson Cancer Center research findings and other news.Reporting on wildfire smoke? Fred Hutch clinicians and researchers are available to their expertise.