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UrduA target trial emulation study found no increased risk for suicidal thoughts or behaviors associated with the use of GLP-1RAs (glucagon-like peptide-1 receptor agonists) to treat type 2 diabetes (T2D).
Tag: Obesity
New Study Finds 40-Percent of Cancer Cases and Almost Half of all Deaths in the U.S. Linked to Modifiable Risk Factors
A new study led by researchers at the American Cancer Society finds four in 10 cancer cases and about one-half of all cancer deaths in adults 30 years old and older in the United States could be attributed to modifiable risk factors, including cigarette smoking, excess body weight, alcohol consumption, physical inactivity, diet, and infections.
Monell Center Discovery Could Help Reduce Adverse Side Effects of Popular Next-generation Obesity Medications
By teasing apart the therapeutic benefits from the adverse effects of new-generation obesity medications, researchers from the Monell Chemical Senses Center found a population of neurons in the brain that controls food intake without causing nausea in an animal model.
Modification of Common Diabetes Drug Improved Blood Sugar Control in Mouse Model
Article title: Reduced incretin receptor trafficking upon activation enhances glycemic control and reverses obesity in diet-induced obese mice Authors: Rathin Bauri, Shilpak Bele, Jhansi Edelli, Neelesh C. Reddy, Sreenivasulu Kurukuti, Tom Devasia, Ahamed Ibrahim, Vishal Rai, Prasenjit Mitra From the authors: “Chronic…
Tip Sheet: Summer science education, new chief nursing officer, DEI program updates — and a new endpoint for multiple myeloma
Below are summaries of recent Fred Hutch Cancer Center research findings, patient stories and other news.
Could Dad’s Diet Influence His Offsprings’ Health?
A study performed in mice has uncovered a potential new tool to combat the escalating issue of childhood obesity. The research suggests that a simple dietary change, in the form of a fish oil supplement taken by fathers, might help address this pressing health concern.
Compound from Olives Shows Promise for Treating Obesity and Diabetes
Findings from a new mouse study suggest that elenolic acid, a natural compound found in olives, can lower blood sugar levels and promote weight loss. The research could pave the way to the development of safe and inexpensive natural products for managing obesity and type 2 diabetes in people.
Pilot Study Provides ‘Blueprint’ for Evaluating Diet’s Effect on Brain Health
Researchers from Johns Hopkins Medicine and the National Institutes of Health’s National Institute on Aging say their study of 40 older adults with obesity and insulin resistance who were randomly assigned to either an intermittent fasting diet or a standard healthy diet approved by the U.S. Department of Agriculture (USDA) offers important clues about the potential benefits of both eating plans on brain health.
From the Pakistan-India Border to Our Borderplex: A Doctor’s Journey Dr. Muhammad Moiz Tahir tackles El Paso’s health challenges with community-driven care
EL PASO, Texas — Some people claim borders are barriers. Others see them as frontiers worthy of exploration. Muhammad Moiz Tahir, M.D., is one of the newest assistant professors in the Foster School of Medicine’s Department of Internal Medicine. Dr.…
Cleveland Clinic Study Shows Weight Loss Surgery Cuts Risk of Heart Complications and Death in Patients with Obstructive Sleep Apnea and Obesity
A Cleveland Clinic study shows that bariatric surgery performed in patients with obesity and moderate to severe obstructive sleep apnea is associated with a significantly lower risk of death and major adverse cardiovascular events, compared with patients who did not have the surgery. This study was published in the Journal of the American College of Cardiology.
Ali Aminian, M.D., director of Cleveland Clinic’s Bariatric & Metabolic Institute and primary investigator of the MOSAIC study, said, “The research shows that weight loss achieved with bariatric surgery is significantly associated with a 42% lower risk of major adverse cardiovascular events and 37% lower risk of death in patients with obesity and moderate to severe obstructive sleep apnea.”
Weight loss: Go nuts or go home
New research from the University of South Australia shows that including nuts in calorie-controlled weight loss diets does not hinder weight loss, and instead may have the opposite effect.
American diets have a long way to go to achieve health equity
Poor diet continues to take a toll on American adults. In a study from the Food is Medicine Institute at the Friedman School of Nutrition Science and Policy at Tufts University published today in the Annals of Internal Medicine, researchers found that diet quality among U.S. adults improved modestly between 1999 and 2020. However, they also found that the number of Americans with poor diet quality remains stubbornly high. Most notably, disparities persist and, in some cases, are worsening.
Obesity-cancer connection discovery suggests strategies for improving immunotherapy
The study reported in the journal Nature provides a mechanistic explanation for the “obesity paradox” — that obesity can contribute to cancer progression but also improve response to immunotherapy.
Physicians debate best management strategy for patient with type 2 diabetes and CKD
In a new Annals ‘Beyond the Guidelines’ feature, an endocrinologist and a nephrologist discuss controversies regarding the care of patients with type 2 diabetes (T2D) and chronic kidney disease (CKD) and how they would apply the consensus statement to the care of an individual patient with T2D who is unaware that he has CKD.
Icahn School of Medicine at Mount Sinai Awarded $21 Million NIH Grant to Advance Understanding of Aging-Related Hormone
Researchers at the Icahn School of Medicine at Mount Sinai have been awarded a $21 million grant from the National Institute on Aging (NIA) of the National Institutes of Health (NIH), to further advance understanding of an aging-related hormone known as follicle-stimulating hormone (FSH), including its potential role in obesity, osteoporosis, and Alzheimer’s disease.
NUTRITION 2024 showcases groundbreaking research on what we eat and why it matters
Be among the first to hear breaking news in food and nutrition science at NUTRITION 2024, the annual flagship meeting of the American Society for Nutrition held June 29–July 2 at McCormick Place in Chicago.
Comparative Study on Dual vs Single Cardioversion for Atrial Fibrillation in Obese Patients
A team of Ochsner Health cardiologists recently published an article in the Journal of the American Medical Association (JAMA) Cardiology comparing two treatment strategies for patients with atrial fibrillation and obesity.
Summer holidays aren’t all fun and games for children’s fitness
The summer holiday break is often considered a time of fun and relaxation for school children, but hand in hand with a respite from routine comes an increase in sedentary behaviour and screen time, and in turn, poorer health and academic outcomes.
Retrospective Study Based on Electronic Health Records Finds Popular Diabetes and Weight-Loss Drugs Associated with Reduction in Incidence and Recurrence of Alcohol-Use Disorder by at Least Half
A new study by researchers at the Case Western Reserve University School of Medicine reveals that the popular diabetes and weight-loss drugs Wegovy and Ozempic are linked to reduced incidence and recurrence of alcohol abuse or dependence.
Two medication classes reduced cardiovascular and liver events in people with type 2 diabetes
GLP-1 receptor agonists (GLP-1s) and SGLT-2 inhibitors lower the risk of major cardiovascular events like heart attacks and severe liver complications compared to other diabetes treatments, according to data being presented Sunday at ENDO 2024, the Endocrine Society’s annual meeting in Boston, Mass.
High insulin levels contribute to worse outcomes for Black women with aggressive form of breast cancer
High insulin levels contribute to worse outcomes for Black women compared to white women who have an aggressive form of breast cancer called triple-negative breast cancer, according to a study presented Sunday at ENDO 2024, the Endocrine Society’s annual meeting in Boston, Mass.
Almost 20% of breast cancer survivors may experience excess weight gain
Almost one out of five breast cancer survivors may experience weight gain of more than 10%, suggests a study presented Monday at ENDO 2024, the Endocrine Society’s annual meeting in Boston, Mass. A number of factors are associated with excessive weight gain, the researchers found.
GLP-1 medications for type 2 diabetes and obesity may lower risk of acute pancreatitis
Medications for type 2 diabetes and obesity known as GLP-1 receptor agonists may lower the risk of acute pancreatitis recurrence in people with obesity and those with type 2 diabetes, according to a study presented Saturday at ENDO 2024, the Endocrine Society’s annual meeting in Boston, Mass.
Risk for heart attack and stroke increases in people with obesity for a decade or more
People under age 50 have a greater risk for heart attack or stroke if they’ve lived with obesity for 10 years, according to industry-sponsored research being presented Saturday at ENDO 2024, the Endocrine Society’s annual meeting in Boston, Mass.
Anti-obesity medication tirzepatide remains effective even for those with diabetes and other complications
Having medical conditions linked to obesity does not impact the total weight loss achieved with the anti-obesity medication tirzepatide, according to an industry-supported study being presented Saturday at ENDO 2024, the Endocrine Society’s annual meeting in Boston, Mass.
GLP-1 has the power to change taste sensitivity in women with obesity
Semaglutide improved taste sensitivity, changed gene expression in the tongue that’s responsible for taste perception, and changed the brain’s response to sweet tastes, according to research presented Saturday at ENDO 2024, the Endocrine Society’s annual meeting in Boston, Mass.
Childhood sedentariness may cause premature liver damage in young adulthood
Children who are sedentary for more than six waking hours a day have a significantly increased risk of severe fatty liver disease and liver cirrhosis by young adulthood, a new study finds. The research findings will be presented Saturday at ENDO 2024, the Endocrine Society’s annual meeting in Boston, Mass and published in Nature’s npj Gut and Liver.
Insurance often denies GLP-1 medications for teens with type 2 diabetes, obesity
Health insurance companies often deny coverage for new medications that treat children and teens with obesity and type 2 diabetes, meaning many patients who need treatment are unable to afford it, according to a study presented at ENDO 2024, the Endocrine Society’s annual meeting in Boston, Mass.
ENDO 2024 press conferences to highlight male birth control, anti-obesity medications
Researchers will delve into emerging research in diabetes, obesity, reproductive health and other aspects of hormone health during the Endocrine Society’s ENDO 2024 news conferences June 1-4.
Lifestyle interventions with dietary strategies after breast cancer diagnosis: a systematic review
Purpose: Obesity can increase mortality and morbidity in breast cancer survivors. Healthy lifestyle factors such as diet can help manage weight in this population. This systematic review examined lifestyle interventions with dietary strategies for breast cancer survivors and their effect on…
Program announced for NUTRITION 2024 to be held June 29–July 2
Reporters are invited to join leading nutrition researchers and professionals at NUTRITION 2024, the annual flagship meeting of the American Society for Nutrition.
CHOP Researchers Identify Causal Genetic Variant Linked to Common Childhood Obesity
Researchers have identified a causal genetic variant strongly associated with childhood obesity. The study provides new insight into the importance of the hypothalamus of the brain and its role in common childhood obesity and the target gene may serve as a druggable target for future therapeutic interventions.
How Obesity Impacts Kidney Tubules in Mice
Rockville, Md. (April 17, 2024)—The lipids in kidney tubular segments (used to carry filtered nutrients to and from the blood) are unknown. In this study, researchers identified, counted and compared more than 500 types of fats. Significant compositional differences were…
Family and media pressure to lose weight in adolescence linked to how people value themselves almost two decades later
People who as teenagers felt pressure to lose weight from family or from the media, females, people who are not heterosexual, and people experiencing socioeconomic disadvantage, are most at risk of ‘internalised’ weight stigma, new research led by the University of Bristol has found. The study is published in The Lancet Regional Health Europe today [16 April].
Study Reveals How Obesity Could Accelerate Aging in the Brain
A new study conducted in mice traces how obesity and a high-fat diet may accelerate aging in the blood vessels that supply blood to the brain. The work is being presented this week at the American Physiology Summit, the flagship annual meeting of the American Physiological Society.
Mayo Clinic study finds active workstations may improve cognitive performance
A recent Mayo Clinic study suggests that active workstations incorporating a walking pad, bike, stepper and/or standing desk are successful strategies for reducing sedentary time and improving mental cognition at work without reducing job performance.
Want to cut U.S. heart risks? Get more people into primary care, study suggests
When someone has a heart attack or a stroke, specialized care can give them the best chance of surviving.
Purrrfect pet nutrition? Illinois expert available for National Pet Day
We all want to do right by our furry friends, but it’s difficult to know what trends are on point to optimize their health and nutrition. Should our dogs go vegan? Will a new type of food help to slim…
Transplant doctor discusses how living kidney donors can help those in need of a transplant.
Eric Martinez, MD, at Baylor Scott & White Health, discusses how living kidney donors can help those in need of a transplant. What You Need to Know: Risk factors that could lead to kidney transplant include high blood pressure and…
Higher Genetic Risk of Obesity Means Working Out Harder for Same Results
Persons with a higher genetic risk of obesity need to work out harder than those of moderate or low genetic risk to avoid becoming obese, according to a Vanderbilt University Medical Center (VUMC) paper published in JAMA Network Open.
Yale Cancer Center experts present new research on obesity, tobacco, evolution, and early onset cancers at leading oncology conference
Yale Cancer Center (YCC) and Smilow Cancer Hospital physicians and scientists will share new data for breakthrough and emerging cancer treatments as well as new discoveries in obesity, tobacco, evolution, and early onset cancers in early April at the American Association for Cancer Research (AACR) annual meeting.
Waist-to-height ratio detects fat obesity in children and adolescents significantly better than BMI, study finds
An inexpensive measure of obesity in children and adolescents that could replace body mass index (BMI) has been identified in a new study as waist circumference-to-height ratio. This measure detected excess fat mass and distinguished fat mass from muscle mass in children and adolescents more accurately than BMI.
Patients With Obesity and Kidney Failure May Be Newly Eligible for Kidney Transplants
A collaborative study between a bariatric and transplant surgery team has introduced new hope for patients suffering from end-stage renal disease (ESRD) who are also struggling with obesity. The study authors explored the outcomes of metabolic and bariatric surgery in ESRD patients and whether the surgery can improve their eligibility for kidney transplants. The findings are published in the Journal of the American College of Surgeons (JACS).
Study Shows Bariatric Surgery Provides Superior Long-Term Treatment for Type 2 Diabetes in Patients with Obesity
Research by Cleveland Clinic and three other U.S. medical centers has found that bariatric surgery provides better long-term control of blood glucose levels in patients with obesity and type 2 diabetes, compared with medical therapy.
Abdominal Fat Can Impact Brain Health and Cognition in High Alzheimer’s Risk Individuals
The impact of abdominal fat on brain health and cognition is generally more pronounced in middle-aged men at high risk of Alzheimer’s disease as opposed to women, according to researchers at Rutgers Health.
UT Southwestern study shows glucagon is key for kidney health
Glucagon, a hormone best known for promoting blood sugar production in the liver, also appears to play a key role in maintaining kidney health. When UT Southwestern Medical Center researchers removed receptors for this hormone from mouse kidneys, the animals developed symptoms akin to chronic kidney disease (CKD).
Could Ultra-processed Foods Be the New ‘Silent’ Killer?
Hundreds of novel ingredients never encountered by human physiology are now found in nearly 60 percent of the average adult’s diet and nearly 70 percent of children’s diets in the U.S. An emerging health hazard is the unprecedented consumption of these ultra-processed foods in the standard American diet. This may be the new “silent” killer, as was unrecognized high blood pressure in previous decades.
Newly discovered genetic markers help pinpoint diabetes risks, complications
UMass Amherst researcher co-leads worldwide efforts to understand how genetic variants are linked with disease to develop new drugs and treatments.
Obesity drugs and mental health: UTSW expert says GLP-1s may exacerbate problems for some patients
New weight-loss drugs have helped people with their diabetes, obesity, even high blood pressure. But how they affect our mental health is a much more complicated issue, says Dr. Carrie McAdams, a psychiatrist and eating disorders expert at UT Southwestern…
Study finds patients happy to get support on how to lose weight during routine dental appointments
As public health experts search for new ways to tackle the obesity crisis, a Loughborough University study has found that patients would welcome support from their dentist on weight management.