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UrduImmunotherapy is not only significantly less effective in liver cancer patients who previously had a liver disease called non-alcoholic steatohepatitis (NASH), but actually appears to fuel tumor growth, according to a Mount Sinai study published in Nature in March. NASH affects as many as 40 million people worldwide and is associated with obesity and diabetes.
Tag: Obesity
Hospitalized COVID-19 patients with obesity are significantly more likely to need ICU care
People with obesity who are hospitalized with COVID-19 have a significantly higher rate of ICU admissions and longer duration of ICU stay compared to people with a normal body mass index (BMI), according to a study presented virtually at ENDO 2021, the Endocrine Society’s annual meeting.
Sleep disturbances may contribute to weight gain in menopause
Addressing sleep symptoms during menopause may reduce susceptibility to weight gain, according to a small study presented virtually at ENDO 2021, the Endocrine Society’s annual meeting.
Genetic evidence suggests men can develop PCOS-like condition
New genetic research suggests men can develop characteristics of polycystic ovary syndrome (PCOS)—a common metabolic and reproductive disorder that affects women. The study was presented virtually at ENDO 2021, the Endocrine Society’s annual meeting.
Semaglutide reduces excess body fat in people with obesity
In adults with obesity or overweight, weekly treatment with the glucagon-like peptide 1 (GLP1) receptor agonist semaglutide leads to reduced excess body fat and increased lean body mass, according to an industry-sponsored study presented virtually at ENDO 2021, the Endocrine Society’s annual meeting.
Lifestyle program improves fertility for women with obesity, infertility
A lifestyle intervention targeting women with obesity and infertility is more effective in increasing the pregnancy rate compared with fertility treatments, according to a study presented virtually at ENDO 2021, the Endocrine Society’s annual meeting.
Obesity raises type 2 diabetes risk in women with PCOS
Women with obesity and polycystic ovarian syndrome (PCOS) are at increased risk of developing type 2 diabetes, according to a study presented virtually at ENDO 2021, the Endocrine Society’s annual meeting. Normal-weight women with PCOS are not at increased risk, the researchers found.
U.S. children from Spanish-speaking households experience higher rate of obesity than those from English-speaking families
Nearly one in five U.S. children and teenagers has obesity, and statistics show a higher prevalence of obesity in certain ethnicities, such as Hispanics and Blacks. Now results of a study being presented at ENDO 2021, the Endocrine Society’s annual meeting, suggest that Spanish as a family’s primary language is a predictor of childhood obesity, regardless of ethnicity.
Exercise is key to strength and function in older women
On their own, exercise and eating higher protein diets are known to help people lose weight and increase strength. But combining both strategies doesn’t necessarily magnify their effects.
Dual health-risk behaviors in young adults: Problem drinking and maladaptive eating both linked to the brain’s reward pathway and impulsivity
Risky drinking often co-occurs with maladaptive eating in young adults, according to a study reported in Alcoholism: Clinical and Experimental Research. While previous research had suggested a link between heavy alcohol use and obesity-related factors in college students, the latest study aimed to identify specific profiles of problematic drinking, food addiction, and obesity within a more diverse sample of community-dwelling young people. The researchers also explored shared theoretical risk factors for heavy drinking and overeating, and how these differ across the profiles. Calorie-dense food and alcohol both require little effort to obtain and consume, and each generates immediate and potent experiences of reward in the brain. According to ‘reinforcer pathology’ theory, people who place a high value (‘demand’) on unhealthy items, and who also favor small immediate rewards (such as food and alcohol) over larger delayed rewards (such as health), are at highest risk for overconsumption
Stress reduction as a path to eating less fast food
Overweight low-income mothers of young kids ate fewer fast-food meals and high-fat snacks after participating in a study – not because researchers told them what not to eat, but because the lifestyle intervention being evaluated helped lower the moms’ stress, research suggests.
Overweight Children Exposed to Lead in Utero May Have Poor Future Kidney Function
Overweight children who were exposed to lead in utero and during their first weeks of life have the potential for poorer kidney function in adulthood, according to an Icahn School of Medicine at Mount Sinai study published in Environment International in March.
Menopausal Changes May Increase Taste for Fat, Drive Weight Gain
A new study in mice suggests that declining estrogen levels lower the taste buds’ sensitivity to fats, which may drive a heightened appetite for fatty foods—and weight gain—after menopause.
Drug Found Effective For Weight Loss in Patients With Obesity And Diabetes, International Study Shows
A drug approved for diabetes has now been shown to also help patients with diabetes lose on average 10 percent of their body weight, UT Southwestern reports in a landmark international study.
Patients on a Low-Calorie Diet along with Intensive Behavioral Therapy Lost Nearly Three Times as Much Weight When Taking New Anti-Obesity Medication, Semaglutide, than When Taking Placebo
A second study of the injectable anti-obesity medication, semaglutide, has confirmed the large weight losses reported in a study earlier this month, establishing the reliability and robustness of this new drug. With obesity affecting more than 40 percent of American adults, the findings could have a major impact on weight management in primary care and other settings.
Obesity may affect puberty timing and hormones in girls
Puberty looks different, in terms of both reproductive hormones and breast maturation, in girls with excess total body fat, according to a new study published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism.
Study Estimates Two-Thirds of COVID-19 Hospitalizations Due to Four Conditions
A new study estimates 64% of adult COVID-19 hospitalizations in the U.S. may have been prevented if there were less obesity, hypertension, diabetes, and heart failure. The model suggests notable differences by age and race/ethnicity in COVID-19 hospitalizations related to these conditions.
Body shape, beyond weight, drives fat stigma for women
Fat stigma in women contributes to poor medical outcomes and negatively affects educational and economic opportunities. A new study from scientists at Arizona State University and Oklahoma State University shows that body shape, beyond overall weight, drives fat stigma. Women with overweight and obesity who carry gluteofemoral fat were less stigmatized than those who carry abdominal fat. These findings could affect how interventions for overweight and obesity are designed and delivered.
Researchers Identify Muscle Factor that Controls Fat Metabolism
In a recent study, published in The Journal of Clinical Investigation, University Hospitals (UH) Cleveland Medical Center and Case Western Reserve University School of Medicine researchers have found that skeletal muscle significantly affects how the body stores and metabolizes fat.
Chinese people may be more susceptible to obesity-related health risks than other racial, ethnic groups
Chinese people are more likely to face high blood pressure and other health risks as a result of higher body mass index (BMI) and waist circumference than people from other racial and ethnic groups, according to a new study published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism.
Exercise during Pregnancy Protects Kids’ Future Health from Parents’ Obesity
New research in mice suggests that exercising during pregnancy may help prevent children—especially boys—from developing health problems related to their parents’ obesity. The study is published ahead of print in the Journal of Applied Physiology. It was chosen as an APSselect article for February.
Pandemic Increases Substance Abuse, Mental Health Issues For Those Struggling With Obesity
DALLAS – Feb. 5, 2021 – The COVID-19 pandemic is having a detrimental impact on substance use, mental health, and weight-related health behaviors among people with obesity, according to a new study by researchers at UT Southwestern and the UTHealth School of Public Health.
Researchers ID Weight and Energy Balance Pathway Independent of Hunger Hormone
Article title: LRP1 regulates food intake and energy balance in GABAergic neurons independently of leptin action Authors: Min-Chel Kang, Ji A. Seo, Hyon Lee, Aykut Uner, Won-Mo Yang, Kellen Cristina Cruz Rodrigues, Hyun Jeong Kim, Wenjing Li, John Nelson Campbell,…
Exercise during Pregnancy Protects Kids’ Future Health from Parents’ Obesity
Article title: Exercise during pregnancy mitigates negative effects of parental obesity on metabolic function in adult mouse offspring Authors: Rhianna Che C. Laker, Ali Altıntaş, Travis S. Lillard, Mei Zhang, Jessica J. Connelly, Olivia L. Sabik, Suna Onengut, Stephen S. Rich,…
When — Not What — Obese Mice Ate Reduced Breast Cancer Risk
University of California San Diego School of Medicine and Moores Cancer Center researchers report that intermittent fasting reduced breast cancer risk in obese mice.
Dietary Adherence and the Fight Against Obesity
While eating less and moving more are the basics of weight control and obesity treatment, finding ways to help people adhere to a weight-loss regimen is more complicated. Understanding what features make a diet easier or more challenging to follow can help optimize and tailor dietary approaches for obesity treatment.
Brain Pressure Disorder that Causes Headache, Vision Problems on Rise
A new study has found a brain pressure disorder called idiopathic intracranial hypertension is on the rise, and the increase corresponds with rising obesity rates. The study is published in the January 20, 2021, online issue of Neurology®, the medical journal of the American Academy of Neurology. The study also found that for women, socioeconomic factors like income, education and housing may play a role in their risk.
Research News Tip Sheet: Story Ideas from Johns Hopkins Medicine
During the COVID-19 pandemic, Johns Hopkins Medicine Media Relations is focused on disseminating current, accurate and useful information to the public via the media. As part of that effort, we are distributing our “COVID-19 Tip Sheet: Story Ideas from Johns Hopkins” every other Tuesday.
Break Up Your Work Day with Healthy Stair Climbing Exercise Snacks
Sitting for long periods is known to have negative effects on metabolic and cardiovascular health. Building on recent work showing that brief bouts of vigorous exercise (exercise “snacks”) can improve fitness, investigators from the University of British Columbia in Canada…
Largest Study of Its Kind Identifies Which COVID-19 Patients Face the Greatest Risk of Mortality During Hospitalization
Hospitalized COVID-19 patients have a greater risk of dying if they are men or are obese or have complications from diabetes or hypertension, according to a new study conducted by University of Maryland School of Medicine (UMSOM) researchers. In a study published in the journal Clinical Infectious Diseases, the researchers evaluated nearly 67,000 hospitalized COVID-19 patients in 613 hospitals across the country to determine link between common patient characteristics and the risk of dying from COVID-19.
Aging, diet-induced obesity, and metabolic disease link explored in new research
Unraveling the links among obesity, aging, telomere lengths and metabolic diseases is the subject of the study published today in Nature Metabolism by a collaborative research team at The University of Texas Health Science Center at Houston (UTHealth).
Different forms of sugar impact hunger-suppressing hormones in young adults
Drinks with sucrose compared to glucose may cause young adults to produce lower levels of appetite-regulating hormones, according to a new study published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism.
Obesity impairs immune cell function, accelerates tumor growth in mice
New study in mice finds that a high-fat diet allows cancer cells to outcompete immune cells for fuel, impairing immune function and accelerating tumor growth. Findings suggest new strategies to target cancer metabolism, improve immunotherapies.
Multiomics, Gentational Cd Exposure, Estrogen Receptor Transactivation, and More Featured in December 2020 Toxicological Sciences
The December 2020 issue of the Society of Toxicology’s official journal, Toxicological Sciences, delivers cutting-edge toxicological research in endocrine toxicology, environmental toxicology, organ-specific toxicology, and more.
Cleveland Clinic Research Shows Bariatric Surgery May Reduce Severity of COVID-19 in Patients with Obesity
CLEVELAND: A Cleveland Clinic study shows that among patients who have obesity and who tested positive for COVID-19, a past history of bariatric surgery was significantly associated with a lower risk of hospital and intensive care unit admission. The results were published in the journal of Surgery for Obesity and Related Diseases.
Antimicrobial Soap Additive Worsens Fatty Liver Disease in Mice
Triclosan, an antimicrobial found in many soaps and other household items, worsens fatty liver disease in mice fed a high-fat diet.
Overweight And Obese Younger People At Greater Risk For Severe COVID-19
DALLAS – Nov. 17, 2020 – Being younger doesn’t protect against the dangers of COVID-19 if you are overweight, according to a new study from UT Southwestern. While all adults who are overweight or obese are at greater risk for serious complications from the disease, the link is strongest for those age 50 and under.
Study finds antibiotics before age 2 associated with childhood health issues
In a retrospective case study, Mayo Clinic researchers have found that antibiotics administered to children younger than 2 are associated with several ongoing illnesses or conditions, ranging from allergies to obesity. The findings appear in Mayo Clinic Proceedings.
Antibiotic Exposure in Children Under Age 2 Associated with Chronic Conditions
Children under age 2 who take antibiotics are at greater risk for childhood-onset asthma, respiratory allergies, eczema, celiac disease, obesity and attention deficit hyperactivity disorder, according to a paper written jointly by Mayo Clinic and Rutgers researchers. While previous studies have looked at the association of antibiotics with single diseases, this is the first to look at the association across many diseases.
In Mice, Cadmium Exposure During Pregnancy Linked to Obesity, Metabolic Issues in Adult Female Offspring
In a mouse study aimed at modeling human exposure to the toxic metal cadmium, researchers found that female offspring of mice exposed to cadmium during pregnancy became obese in adulthood, developed fatty livers and could not process glucose normally. Male offspring were not affected in the same way.
Simultaneous kidney transplant plus weight loss surgery safe for obese patients
A new study shows that robotic-assisted kidney transplant and weight loss surgery can be performed safely.
All Weight Loss Isn’t Equal For Reducing Heart Failure Risk
DALLAS – Nov. 9, 2020 – Reducing the level of body fat and waist size are linked to a lower risk of heart failure in patients with type 2 diabetes, a study led by UT Southwestern researchers indicates. The findings, reported today in Circulation, suggest that all weight loss isn’t equal when it comes to mitigating the risk of heart disease.
Home-Visiting Program Shows Promise of Reducing Risk of Obesity Among Native American Children
Lessons on healthy feeding practices delivered to young mothers through a brief home-visiting intervention put Native American infants on a healthier growth trajectory, lowering their risks for obesity.
HIIT Increased Aerobic Capacity but Didn’t Improve Peripheral Insulin Sensitivity in Insulin-resistant or Insulin-sensitive Obese Adults
Researchers from the University of Michigan contend that HIIT promotes important metabolic health benefits in adults with obesity. This study indicates 12 weeks of HIIT increased aerobic capacity similarly in both insulin-resistant and insulin-sensitive obese adults, but it did not…
Maternal Obesity May Cause Impaired Fetal Muscle Development and Metabolic Disorder
Article title: An obesogenic maternal environment impairs mouse growth patterns, satellite cell activation and markers of post-natal myogenesis Authors: Jasmine Mikovic, Camille R. Brightwell, Angus Lindsay, Yuan Wen, Greg Kowalski, Aaron P. Russell, Christopher S. Fry, Séverine Lamon From the authors:…
Severe Obesity in Type 2 Diabetes Causes Impaired Glucose Metabolism in Muscle Cells
Article title: Impaired glucose partitioning in primary myotubes from severely obese women with type 2 diabetes Authors: Kai Zou, Kristen Turner, Donghai Zheng, J. Matthew Hinkley, Benjamin A. Kugler, Pamela J. Hornby, James M. Lenhard, Terry E. Jones, Walter J. Pories,…
Mount Sinai Researchers Develop a First-in-Class Humanized Antibody Targeting Bone and Fat
Blocking the Follicle-Stimulating Hormone (FSH) whose levels rise at menopause could solve bone loss and weight gain Senior Author: Mone Zaidi, MD, PhD, MACP, Director of the Mount Sinai Bone Program and Professor of Medicine (Endocrinology, Diabetes and Bone Disease) at…
High-fat Diet in Childhood May Affect Sperm Later in Life
New research in mice suggests that a high-fat diet early in life may impair male fertility in adulthood. The first-of-its-kind study is published ahead of print in the American Journal of Physiology-Endocrinology and Metabolism.
Mount Sinai Researchers Find That Where People Live Can Impact Their Risk for Common Chronic Conditions Including High Blood Pressure and Depression
The researchers found that a persons’ place of residence substantially influences their risk of uncontrolled chronic disease including high blood pressure and depression
Research News Tip Sheet: Story Ideas From Johns Hopkins Medicine
During the COVID-19 pandemic, Johns Hopkins Medicine Media Relations is focused on disseminating current, accurate and useful information to the public via the media. As part of that effort, we are distributing our “COVID-19 Tip Sheet: Story Ideas from Johns Hopkins” every other Tuesday.