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UrduNew study in mice finds that a high-fat diet allows cancer cells to outcompete immune cells for fuel, impairing immune function and accelerating tumor growth. Findings suggest new strategies to target cancer metabolism, improve immunotherapies.
Tag: Obesity
Multiomics, Gentational Cd Exposure, Estrogen Receptor Transactivation, and More Featured in December 2020 Toxicological Sciences
The December 2020 issue of the Society of Toxicology’s official journal, Toxicological Sciences, delivers cutting-edge toxicological research in endocrine toxicology, environmental toxicology, organ-specific toxicology, and more.
Cleveland Clinic Research Shows Bariatric Surgery May Reduce Severity of COVID-19 in Patients with Obesity
CLEVELAND: A Cleveland Clinic study shows that among patients who have obesity and who tested positive for COVID-19, a past history of bariatric surgery was significantly associated with a lower risk of hospital and intensive care unit admission. The results were published in the journal of Surgery for Obesity and Related Diseases.
Antimicrobial Soap Additive Worsens Fatty Liver Disease in Mice
Triclosan, an antimicrobial found in many soaps and other household items, worsens fatty liver disease in mice fed a high-fat diet.
Overweight And Obese Younger People At Greater Risk For Severe COVID-19
DALLAS – Nov. 17, 2020 – Being younger doesn’t protect against the dangers of COVID-19 if you are overweight, according to a new study from UT Southwestern. While all adults who are overweight or obese are at greater risk for serious complications from the disease, the link is strongest for those age 50 and under.
Study finds antibiotics before age 2 associated with childhood health issues
In a retrospective case study, Mayo Clinic researchers have found that antibiotics administered to children younger than 2 are associated with several ongoing illnesses or conditions, ranging from allergies to obesity. The findings appear in Mayo Clinic Proceedings.
Antibiotic Exposure in Children Under Age 2 Associated with Chronic Conditions
Children under age 2 who take antibiotics are at greater risk for childhood-onset asthma, respiratory allergies, eczema, celiac disease, obesity and attention deficit hyperactivity disorder, according to a paper written jointly by Mayo Clinic and Rutgers researchers. While previous studies have looked at the association of antibiotics with single diseases, this is the first to look at the association across many diseases.
In Mice, Cadmium Exposure During Pregnancy Linked to Obesity, Metabolic Issues in Adult Female Offspring
In a mouse study aimed at modeling human exposure to the toxic metal cadmium, researchers found that female offspring of mice exposed to cadmium during pregnancy became obese in adulthood, developed fatty livers and could not process glucose normally. Male offspring were not affected in the same way.
Simultaneous kidney transplant plus weight loss surgery safe for obese patients
A new study shows that robotic-assisted kidney transplant and weight loss surgery can be performed safely.
All Weight Loss Isn’t Equal For Reducing Heart Failure Risk
DALLAS – Nov. 9, 2020 – Reducing the level of body fat and waist size are linked to a lower risk of heart failure in patients with type 2 diabetes, a study led by UT Southwestern researchers indicates. The findings, reported today in Circulation, suggest that all weight loss isn’t equal when it comes to mitigating the risk of heart disease.
Home-Visiting Program Shows Promise of Reducing Risk of Obesity Among Native American Children
Lessons on healthy feeding practices delivered to young mothers through a brief home-visiting intervention put Native American infants on a healthier growth trajectory, lowering their risks for obesity.
HIIT Increased Aerobic Capacity but Didn’t Improve Peripheral Insulin Sensitivity in Insulin-resistant or Insulin-sensitive Obese Adults
Researchers from the University of Michigan contend that HIIT promotes important metabolic health benefits in adults with obesity. This study indicates 12 weeks of HIIT increased aerobic capacity similarly in both insulin-resistant and insulin-sensitive obese adults, but it did not…
Maternal Obesity May Cause Impaired Fetal Muscle Development and Metabolic Disorder
Article title: An obesogenic maternal environment impairs mouse growth patterns, satellite cell activation and markers of post-natal myogenesis Authors: Jasmine Mikovic, Camille R. Brightwell, Angus Lindsay, Yuan Wen, Greg Kowalski, Aaron P. Russell, Christopher S. Fry, Séverine Lamon From the authors:…
Severe Obesity in Type 2 Diabetes Causes Impaired Glucose Metabolism in Muscle Cells
Article title: Impaired glucose partitioning in primary myotubes from severely obese women with type 2 diabetes Authors: Kai Zou, Kristen Turner, Donghai Zheng, J. Matthew Hinkley, Benjamin A. Kugler, Pamela J. Hornby, James M. Lenhard, Terry E. Jones, Walter J. Pories,…
Mount Sinai Researchers Develop a First-in-Class Humanized Antibody Targeting Bone and Fat
Blocking the Follicle-Stimulating Hormone (FSH) whose levels rise at menopause could solve bone loss and weight gain Senior Author: Mone Zaidi, MD, PhD, MACP, Director of the Mount Sinai Bone Program and Professor of Medicine (Endocrinology, Diabetes and Bone Disease) at…
High-fat Diet in Childhood May Affect Sperm Later in Life
New research in mice suggests that a high-fat diet early in life may impair male fertility in adulthood. The first-of-its-kind study is published ahead of print in the American Journal of Physiology-Endocrinology and Metabolism.
Mount Sinai Researchers Find That Where People Live Can Impact Their Risk for Common Chronic Conditions Including High Blood Pressure and Depression
The researchers found that a persons’ place of residence substantially influences their risk of uncontrolled chronic disease including high blood pressure and depression
Research News Tip Sheet: Story Ideas From Johns Hopkins Medicine
During the COVID-19 pandemic, Johns Hopkins Medicine Media Relations is focused on disseminating current, accurate and useful information to the public via the media. As part of that effort, we are distributing our “COVID-19 Tip Sheet: Story Ideas from Johns Hopkins” every other Tuesday.
Genetic differences in fat shape men and women’s health risks
New findings about body fat help explain the differing health risks men and women face – and set the stage for better, more targeted treatments.
World first study links obesity with reduced brain plasticity
A world-first study has found that severely overweight people are less likely to be able to re-wire their brains and find new neural pathways, a discovery that has significant implications for people recovering from a stroke or brain injury.
Cleveland Clinic Study Identifies Weight-Loss Threshold for Cardiovascular and Survival Benefits in Patients with Obesity and Diabetes
A Cleveland Clinic study shows that 5 to 10 percent of surgically induced weight loss is associated with improved life expectancy and cardiovascular health. In comparison, about 20 percent weight loss is necessary to observe similar benefits with a non-surgical treatment. The findings also show that metabolic surgery may contribute health benefits that are independent of weight loss. The study is published in the October issue of Annals of Surgery.
Prevent Severe COVID Symptoms With Lifestyle Changes
Obesity is contributing to worse outcomes in people with COVID-19. Dr. Naomi Parrella, medical director of the Rush Center for Weight Loss and Bariatric Surgery, explains how managing your weight can lower your risk for severe COVID symptoms and help you prevent other chronic diseases.
Factors Inherent to Obesity Could Increase Vulnerability to COVID-19
DALLAS – Sept. 15, 2020 – Conditions related to obesity, including inflammation and leaky gut, leave the lungs of obese patients more susceptible to COVID-19 and may explain why they are more likely to die from the disease, UTSW scientists say in a new article published online in eLife. They suggest that drugs used to lower inflammation in the lungs could prove beneficial to obese patients with the disease.
Exercise and Insulin Metabolism in NAFLD
The obesity epidemic has led to an increase in the number of people who have a form of liver disease known as nonalcoholic fatty liver disease, or NAFLD. The disease can cause dangerous levels of fat to build up in…
Stress Responder Protein Found to Protect against Metabolic, Gut Changes in Mice
New research in mice suggests a protein found predominately in white blood cells helps keep gastrointestinal bacteria in balance and may protect against metabolic disorders.
Diabetes-in-a-dish model uncovers new insights into the cause of type 2 diabetes
Researchers have developed a novel ‘disease-in-a-dish’ model to study the basic molecular factors that lead to the development of type 2 diabetes, uncovering the potential existence of major signaling defects both inside and outside of the classical insulin signaling cascade, and providing new perspectives on the mechanisms behind insulin resistance in type 2 diabetes and possibly opportunities for the development of novel therapeutics for the disease.
Obesity may alter immune system response to COVID-19
Obesity may cause a hyperactive immune system response to COVID-19 infection that makes it difficult to fight off the virus, according to a new manuscript published in the Endocrine Society’s journal, Endocrinology.
Sulfatase 2 Plays Role in Development of Obesity-induced Fatty Liver Disease
Article title: Knockout of sulfatase 2 is associated with decreased steatohepatitis and fibrosis in a mouse model of nonalcoholic fatty liver disease Authors: Tae Hyo Kim, Bubu A. Banini,* Faizal Z. Asumda, Nellie A. Campbell, Chunling Hu, Catherine D. Moser, Abdirashid…
Fat Tissue Inflammation Directly Linked to Obesity-Induced Insulin Resistance
Adipose (fat) tissue inflammation is directly linked to obesity-induced insulin resistance, while gut imbalance and mitochondrial dysfunction are not required. These are the findings of new research published in Function, the latest addition to the American Physiological Society’s collection of…
Infants in Households With Very Low Food Security May Have Greater Obesity Risk
Infants from households reporting very low “food security,” a measure of access to adequate and healthy meals, tend to weigh more than those from households with relatively high food security.
Transplanted brown-fat-like cells hold promise for obesity and diabetes
A potential therapy for obesity would transplant HUMBLE (human brown-like) fat cells, human white fat cells that have been genetically modified using CRISPR to become similar to heat-generating brown fat cells.
Excessive Fructose Consumption May Cause a Leaky Gut, Leading to Fatty Liver Disease
Researchers at University of California San Diego School of Medicine report that fructose only adversely affects the liver after it reaches the intestines, where the sugar disrupts the epithelial barrier protecting internal organs from bacterial toxins in the gut.
Stomach Capacity, Desire to Eat Increases at Buffets
Research suggests stomach capacity in obesity changes to accommodate different eating situations, which has an effect on feelings of fullness and the urge to overeat. The study is published in the American Journal of Physiology-Gastrointestinal and Liver Physiology.
Major weight loss — whether from surgery or diet — has same metabolic benefits
A longstanding theory has suggested that gastric bypass surgery may have unique, weight loss-independent effects in treating type 2 diabetes. But new research from Washington University School of Medicine in St. Louis indicates that weight loss after surgery, rather than the surgery itself, drives metabolic improvements, such as the remission of diabetes.
Sugar Causes Obesity Even without Sweet Taste
Article title: Sugar causes obesity and metabolic syndrome in mice independently of sweet taste Authors: Ana Andres-Hernando, Masanari Kuwabara, David J. Orlicky, Aurelie Vandenbeuch, Christina Cicerchi, Sue C. Kinnamon, Thomas E. Finger, Richard J. Johnson, Miguel A. Lanaspa From the authors:…
High-fat Diet and Genetics Lead to Anxiety and Depression in Rats
New research in a genetically diverse rat strain finds high-fat diet and genetics together increase anxiety and depression-like behavior in addition to negatively affecting metabolic health. The study is published ahead of print in Physiological Genomics.
Wayne State-led team explores link between diabetes, obesity and liver disease
Faculty from Wayne State University’s Eugene Applebaum College of Pharmacy and Health Sciences are leading a team of researchers to understand the causal relationships between diabetes, obesity and nonalcoholic fatty liver disease in hopes of developing a treatment.
NIH Awards $9.5 Million for Einstein-Mount Sinai Diabetes Research Center
Albert Einstein College of Medicine has received a $9.5 million, five-year grant from the National Institutes of Health (NIH) to support the Einstein-Mount Sinai Diabetes Research Center (ES-DRC). The multi-institutional center is a leader in basic, translational, clinical, and community-based research and training in type 1 and type 2 diabetes, obesity, and other metabolic disorders.
Double Surgery Improves Chances for Heart Transplant in Patients with Obesity
Pairing bariatric surgery with LVAD heart surgery may be an effective bridge to heart transplant for obese patients.
Study finds weight loss surgery cost disparity
A new study from the University of Georgia finds that users of public insurance are paying more for bariatric weight loss surgery compared to private insurance patients.
Macrophages Play Important Role in Pediatric Obesity-associated Kidney Disease
Article title: Depletion of macrophages slows the early progression of renal injury in obese Dahl salt-sensitive leptin receptor mutant rats Authors: Bibek Poudel, Corbin A. Shields, Andrea K. Brown, Ubong Ekperikpe, Tyler Johnson, Denise C. Cornelius, Jan M. Williams From the…
Ohio State Study: Exercise Increases Benefits Of Breastmilk For Babies
A new study led by researchers at The Ohio State University Wexner Medical Center and College of Medicine finds even moderate exercise during pregnancy increases a compound in breast milk that reduces a baby’s lifelong risks of serious health issues such as diabetes, obesity and heart disease.
2020 Warren Alpert Prize Recognizes Seminal Discoveries in Metabolism
The 2020 Warren Alpert Foundation Prize has been awarded to a trio of researchers for seminal discoveries about the function of key intestinal hormones, their effects on metabolism and the subsequent design of treatments for type 2 diabetes, obesity and short bowel syndrome.
People who eat a late dinner may gain weight
Eating a late dinner may contribute to weight gain and high blood sugar, according to a small study published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism.
Obesity Patients Report Health Challenges During Shelter in Place
Shelter-in-place orders to reduce the spread of COVID-19 put unusual strains on people with obesity, making it more difficult for them to eat properly and manage their weight, according to a UT Southwestern study.
Mexican Immigrant Obesity Rates Climb with Deportation Fears
Stress, unhealthy foods contribute to obesity in undocumented adults and children, Rutgers study reports
Leaders Call for ‘Moonshot’ on Nutrition Research
Leading nutrition and food policy experts outline a bold case for strengthening federal nutrition research in a live interactive session as part of NUTRITION 2020 LIVE ONLINE, a virtual conference hosted by the American Society for Nutrition (ASN).
Study Suggests Low-carbohydrate, High-fat Diet Protects against Obesity
Article title: Dietary carbohydrates modulate metabolic and β-cell adaptation to high-fat diet-induced obesity Authors: Tracy K. Her, William S. Lagakos, Matthew R. Brown, Nathan K. LeBrasseur, Kuntol Rakshit, Aleksey V. Matveyenko From the authors: “These studies support the hypothesis that low carbohydrate/high…
Dieting? Studies Weigh In on Opportunities and Risks
Get the latest research findings on fad diets, losing weight and healthful eating at NUTRITION 2020 LIVE ONLINE, a virtual conference featuring leading nutrition experts from around the world.
Expert on how to keep motivated and maintain weight during COVID-19
When it comes to weight gain, Professor Riebe notes, “Weight and weight gain is very complex, but to simplify, it really boils down to energy in, energy out, or what you’re taking in as food, and your physical activity. So,…